DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation

Journal of Biological Chemistry

Volumn 288, Issue 27, 2013, Pages 19537-19547

  Tzarum, Netanel ^a   Komornik, Nadav ^a   Chetrit, Dorin Ben ^a   Engelberg, David ^a   Livnah, Oded ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHOSPHORYLATION; PROTEIN-PROTEIN INTERACTIONS; SELECTIVE INTERACTION; SIGNALING PATHWAYS; SIGNALING PROCESS; SUBSTRATE ACTIVATION; SUBSTRATE SELECTIVITY; SYNTHETIC PEPTIDE;

CELL DEATH; CELL PROLIFERATION; ENZYMES; PHOSPHORYLATION; PROTEINS;

SUBSTRATES;

ALANINE; CELL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MK2 KINASE; MYELIN BASIC PROTEIN; PHOSPHOTRANSFERASE; PROTEIN ATFII; THREONINE; TRANSCRIPTION FACTOR ELK 1; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; COMMON DOCKING DOMAIN; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEF SITE INTERACTION POCKET; ENZYME ACTIVATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; EUKARYOTE; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

AUTOPHOSPHORYLATION; DOCKING REGION; MAP KINASE; MAP KINASES (MAPKS); MOLECULAR DOCKING; P38; PROTEIN PHOSPHORYLATION; SUBSTRATE SELECTIVITY; THREONINE-SERINE PROTEIN KINASE;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 14; MUTATION; PEPTIDES; PHOSPHORYLATION; SUBSTRATE SPECIFICITY;

EID: 84880047467     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.464511     Document Type: Article

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