Mutation of cysteine residues alters the heme-binding pocket of indoleamine 2,3-dioxygenase-1

Biochemical and Biophysical Research Communications

Volumn 436, Issue 4, 2013, Pages 595-600

  Austin, Christopher J D ^a,b   Kosim Satyaputra, Priambudi ^a   Smith, Jason R ^a   Willows, Robert D ^a   Jamie, Joanne F ^a  

^a MACQUARIE UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Altered substrate binding site; Cysteine residues; Indoleamine 23 dioxygenase; Kynurenine pathway; Site directed mutagenesis; Tryptophan metabolism

Indexed keywords

CYSTEINE; HEME; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE 1; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BETA SHEET; CIRCULAR DICHROISM; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; WILD TYPE;

ALTERED SUBSTRATE BINDING SITE; CYSTEINE RESIDUES; INDOLEAMINE 23-DIOXYGENASE; KYNURENINE PATHWAY; SITE-DIRECTED MUTAGENESIS; TRYPTOPHAN METABOLISM;

BINDING SITES; CATALYSIS; CYSTEINE; ENZYME STABILITY; HEME; HUMANS; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS;

MAMMALIA;

EID: 84880046233     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.05.119     Document Type: Article

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