Focusing on the structure and the function of Pin1: New insights into the opposite effects of fever on cancers and Alzheimer's disease

Medical Hypotheses

Volumn 81, Issue 2, 2013, Pages 282-284

  Wang, Jing Zhang ^a   Zhang, Yu Hua ^a   Sun, Xue Wen ^a   Li, Ya Li ^b   Li, Shu Rui ^b   Zhang, Yong ^a   Zhang, Ting ^a   Song, Guo Qiang ^a  

^a HEBEI UNIVERSITY OF ENGINEERING   (China)

^b Handan Central Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDYLPROLYL ISOMERASE PIN1;

ALZHEIMER DISEASE; ARTICLE; CANCER RISK; ENZYME ACTIVITY; ENZYME STRUCTURE; FEVER; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPERTHERMIA; HYPERTHERMIC THERAPY; IN VIVO STUDY; MOLECULAR MECHANICS; NEOPLASM; PATHOGENESIS; PROTEIN FUNCTION; RISK ASSESSMENT; RISK REDUCTION; TEMPERATURE STRESS;

AΒ; AD; ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEIN; AMYLOID-Β; APP; NEUROFIBRILLARY TANGLES; NFTS;

ALZHEIMER DISEASE; DOWN-REGULATION; EVIDENCE-BASED MEDICINE; FEVER; HUMANS; MODELS, THEORETICAL; NEOPLASMS; PEPTIDYLPROLYL ISOMERASE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84880037170     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2013.04.029     Document Type: Article

References (49)

1. Driver J.A., Lu K.P. Pin1: a new genetic link between Alzheimer's disease, cancer and aging. Curr Aging Sci 2010, 3:158-165.
2. Driver J.A. Understanding the link between cancer and neurodegeneration. J Geriatr Oncol 2012, 3:58-67.
3. Roe C.M., Behrens M.I., Xiong C., Miller J.P., Morris J.C. Alzheimer disease and cancer. Neurology 2005, 64:895-898.
4. Yamada M., Sasaki H., Mimori Y., et al. Prevalence and risks of dementia in the Japanese population: RERF's Adult Health Study Hiroshima subjects. J Am Geriatr Soc 1999, 47:189-195.
5. Behrens M.I., Lendon C., Roe C.M. A common biological mechanism in cancer and Alzheimer's disease?. Curr Alzheimer Res 2009, 6:196-204.
6. Roe C.M., Morris J.C., Fitzpatrick A., Behrens M.I. Cancer linked to Alzheimer disease but not vascular dementia reply. Neurology 2010, 75:1216.
7. Lee T.H., Pastorino L., Lu K.P. Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease. Expert Rev Mol Med 2011, 13:e21.
8. Wang J.Z., Lin T., Teng T., Xie S.S., Zhu G.F., Du L.F. Spectroscopic studies on the irreversible heat-induced structural transition of Pin1. Spectrochim Acta A Mol Biomol Spectrosc 2011, 78:142-147.
9. Wang J.Z., Lin T., Zhu G.F., Du L.F. Stability of Pin1 as revealed by thermal and spectroscopic studies. J Mol Struct 2010, 975:310-316.
10. Wang J.Z., Xi L., Zhu G.F., et al. The acidic pH-induced structural changes in Pin1 as revealed by spectral methodologies. Spectrochim Acta A Mol Biomol Spectrosc 2012, 98:199-206.
11. Lu K.P., Hanes S.D., Hunter T. A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 1996, 380:544-547.
12. Liou Y.C., Zhou X.Z., Lu K.P. Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci 2011, 36:501-514.
13. Lu K.P. Pinning down cell signaling, cancer and Alzheimer's disease. Trends Biochem Sci 2004, 29:200-209.
14. Wulf G.M., Ryo A., Wulf G.G., et al. Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J 2001, 20:3459-3472.
15. Ryo A., Nakamura M., Wulf G., Liou Y.C., Lu K.P. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 2001, 3:793-801.
16. Ryo A., Suizu F., Yoshida Y., et al. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell 2003, 12:1413-1426.
17. Liou Y.C., Sun A., Ryo A., et al. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 2003, 424:556-561.
18. Pastorino L., Sun A., Lu P.J., et al. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature 2006, 440:528-534.
19. Lu K.P., Patorino L., Ma S.L., Nakamura K., Driver J., Zhou X.Z. Pin1 protects against tau and Abeta-related pathologies and delays onset of Alzheimer's disease. Alzheimers Dement 2010, 6:S154-S155.
20. Ma S.L., Pastorino L., Zhou X.Z., Lu K.P. Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3beta (GSK3beta) activity: novel mechanism for Pin1 to protect against Alzheimer disease. J Biol Chem 2012, 287:6969-6973.
21. Bailey M.L., Shilton B.H., Brandl C.J., Litchfield D.W. The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role. Biochemistry 2008, 47:11481-11489.
22. Jager M., Nguyen H., Dendle M., Gruebele M., Kelly J.W. Influence of hPin1 WW N-terminal domain boundaries on function, protein stability, and folding. Protein Sci 2007, 16:1495-1501.
23. Kaul R., Angeles A.R., Jager M., Powers E.T., Kelly J.W. Incorporating beta-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded beta-sheets. J Am Chem Soc 2001, 123:5206-5212.
24. Bullock A.N., Henckel J., Fersht A.R. Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy. Oncogene 2000, 19:1245-1256.
25. Mori T., Hidaka M., Lin Y.C., et al. A dual inhibitor against prolyl isomerase Pin1 and cyclophilin discovered by a novel real-time fluorescence detection method. Biochem Biophys Res Commun 2011, 406:439-443.
26. Tatara Y., Lin Y.C., Bamba Y., Mori T., Uchida T. Dipentamethylene thiuram monosulfide is a novel inhibitor of Pin1. Biochem Biophys Res Commun 2009, 384:394-398.
27. Kleef R., Jonas W.B., Knogler W., Stenzinger W. Fever, cancer incidence and spontaneous remissions. Neuroimmunomodulation 2001, 9:55-64.
28. Al-Tawfiq J.A., Al-Khatti A.A. Spontaneous remission of acute monocytic leukemia after infection with Clostridium septicum. Int J Lab Hematol 2007, 29:386-389.
29. Hoption S.A., van Netten J.P., van Netten C. Acute infections as a means of cancer prevention: opposing effects to chronic infections?. Cancer Detect Prev 2006, 30:83-93.
30. Nagorsen D., Marincola F.M., Kaiser H.E. Bacteria-related spontaneous and therapeutic remission of human malignancies. In Vivo 2002, 16:551-556.
31. Rubovszky G., Nagy T., Godeny M., Szasz A., Lang I. Successful treatment of solitary bone metastasis of non-small cell lung cancer with bevacizumab and hyperthermia. Pathol Oncol Res 2013, 19:119-122.
32. Xiao F., Liu B., Zhu Q.-X. C-Jun N-terminal kinase is required for thermotherapy-induced apoptosis in human gastric cancer cells. World J Gastroenterol 2012, 18:7348-7356.
33. Kim J.A., Connors B.W. High temperatures alter physiological properties of pyramidal cells and inhibitory interneurons in hippocampus. Front Cell Neurosci 2012, 6.
34. Andersen P., Moser E.I. Brain temperature and hippocampal function. Hippocampus 1995, 5:491-498.
35. Atkins E. Fever: the old and the new. J Infect Dis 1984, 149:339-348.
36. Duffell E. Curative power of fever. Lancet 2001, 358:1276.
37. Whitrow M. Wagner-Jauregg and fever therapy. Med Hist 1990, 34:294-310.
38. Robertson G.M. The prevention of insanity - a preliminary survey of the problem. Lancet 1926, 2:158-159.
39. Curran L.K., Newschaffer C.J., Lee L.-C., Crawford S.O., Johnston M.V., Zimmerman A.W. Behaviors associated with fever in children with autism spectrum disorders. Pediatrics 2007, 120:E1386-E1392.
40. Bilbo S.D., Yirmiya R., Amat J., Paul E.D., Watkins L.R., Maier S.F. Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats. Psychoneuroendocrinology 2008, 33:261-269.
41. Conti B., Tabarean I., Andrei C., Bartfai T. Cytokines and fever. Front Biosci 2004, 9:1433-1449.
42. Tsai M.J., Hsu Y.L., Wu K.Y., et al. Production of inflammatory cytokines through heat shock protein 90 pathway in cornea cells. Curr Eye Res 2013, 38:464-471.
43. Hsu Y.L., Yu H.S., Lin H.C., Wu K.Y., Yang R.C., Kuo P.L. Heat shock induces apoptosis through reactive oxygen species involving mitochondrial and death receptor pathways in corneal cells. Exp Eye Res 2011, 93:405-412.
44. Wu J., Javedan S.P., Ellsworth K., Smith K., Fisher R.S. Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices. BMC Neurosci 2001, 2:18.
45. Aydin M., Girgin F.I., Kabakus N., et al. Evaluation of effects of experimental exogenous fever, hyperthermia and various drugs on infant rat brain. Nobel Med 2012, 8:66-75.
46. Favero-Filho L.A., Borges A.A., Grassl C., Lopes A.C., Sinigaglia-Coimbra R., Coimbra C.G. Hyperthermia induced after recirculation triggers chronic neurodegeneration in the penumbra zone of focal ischemia in the rat brain. Braz J Med Biol Res 2008, 41:1029-1036.
47. Wang X.Y., Ostberg J.R., Repasky E.A. Effect of fever-like whole-body hyperthermia on lymphocyte spectrin distribution, protein kinase C activity, and uropod formation. J Immunol 1999, 162:3378-3387.
48. Sinigaglia-Coimbra R., Giordani F., Stavale N., et al. Behavioral and morphological study on the Alzheimer-like rat model induced by postischemic hyperthermia. J Neurol Sci 2005, 229:350-351.
49. Sinigaglia-Coimbra R., Cavalheiro E.A., Coimbra C.G. Postischemic hyperthermia induces Alzheimer-like pathology in the rat brain. Acta Neuropathol 2002, 103:444-452.