Inhibitory action of salicylideneamino-2-thiophenol on NF-κB signaling cascade and cyclooxygenase-2 in HNE-treated endothelial cells

Archives of Pharmacal Research

Volumn 36, Issue 7, 2013, Pages 880-889

  Park, Seongjoon ^a   Sung, Bokyung ^a   Jang, Eun Ji ^a   Kim, Dae Hyun ^a   Park, Chan Hum ^a   Choi, Yeon Ja ^a   Ha, Young Mi ^a   Kim, Mi Kyung ^a   Kim, Nam Deuk ^a   Yu, Byung Pal ^a,b   Chung, Hae Young ^a  

^a Pusan National University   (South Korea)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

HNE; Inflammation; NF B; Reactive species; Salicylate; Salicylideneamino 2 thiophenol

Indexed keywords

2 SALICYLIDENEAMINOPHENOL; 4 HYDROXYNONENAL; CYCLOOXYGENASE 2; GLUTATHIONE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; PENICILLAMINE; PEROXYNITRITE; PROSTAGLANDIN E2; SALICYLIC ACID; SALICYLIDENEAMINO 2 THIOPHENOL; TROLOX C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; INFLAMMATORY DISEASE; MALE; NONHUMAN; OXIDATIVE STRESS; PROSTATE; RAT; REDOX STRESS; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ALDEHYDES; ANIMALS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; ENDOTHELIAL CELLS; NF-KAPPA B; RATS; REACTIVE OXYGEN SPECIES; SALICYLATES; SIGNAL TRANSDUCTION; SULFHYDRYL COMPOUNDS;

EID: 84880036183     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0116-4     Document Type: Article

References (45)

1. Abate, A., G. Yang, P.A. Dennery, S. Oberle, and H. Schroder. 2000. Synergistic inhibition of cyclooxygenase-2 expression by vitamin E and aspirin. Free Radical Biology and Medicine 29: 1135-1142.
2. Ali, S.F., C.P. Lebel, and S.C. Bondy. 1992. Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology 13: 637-648.
3. Amann, R., T. Egger, R. Schuligoi, A. Heinemann, and B.A. Peskar. 2001. Sodium salicylate enhances the expression of cyclooxygenase-2 in endotoxin-stimulated human mononuclear cells. European Journal of Pharmacology 433: 129-134.
4. Beharka, A.A., D. Wu, S.N. Han, and S.N. Meydani. 1997. Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E. Mechanisms of Ageing and Development 93: 59-77.
5. Chun, K.S., and Y.J. Surh. 2004. Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochemical Pharmacology 68: 1089-1100.
6. Chung, C.K., H.N. Koo, K.Y. Chung, T. Shin, H.R. Kim, H.J. Chae, N.H. An, C.H. Kim, and H.M. Kim. 2000. Inhibitory effect of sodium salicylate on nitric oxide production from TM4 sertoli cells. International Journal of Immunopharmacology 22: 685-692.
7. Chung, J., H.S. Lee, H.Y. Chung, T.R. Yoon, and H.K. Kim. 2008. Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages. Biotechnology Letters 30: 1553-1558.
8. Crofford, L.J., R.L. Wilder, A.P. Ristimaki, H. Sano, E.F. Remmers, H.R. Epps, and T. Hla. 1994. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. Journal of Clinical Investment 93: 1095-1101.
9. Dong, Z., C. Huang, R.E. Brown, and W.Y. Ma. 1997. Inhibition of activator protein 1 activity and neoplastic transformation by aspirin. Journal of Biological Chemistry 272: 9962-9970.
10. Esterbauer, H., R.J. Schaur, and H. Zollner. 1991. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radical Biology and Medicine 11: 81-128.
11. Fiebich, B.L., and S. Chrubasik. 2004. Effects of an ethanolic salix extract on the release of selected inflammatory mediators in vitro. Phytomedicine 11: 135-138.
12. Garg, A.K., and B.B. Aggarwal. 2002. Reactive oxygen intermediates in TNF signaling. Molecular Immunology 39: 509-517.
13. Goppelt-Struebe, M. 1995. Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression. Prostaglandins Leukotrienes and Essential Fatty Acids 52: 213-222.
14. Ho, F.M., C.C. Lai, L.J. Huang, T.C. Kuo, C.M. Chao, and W.W. Lin. 2004. The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages. British Journal of Pharmacology 141: 1037-1047.
15. Inoue, H., C. Yokoyama, S. Hara, Y. Tone, and T. Tanabe. 1995. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. Journal of Biological Chemistry 270: 24965-24971.
16. Kamata, H., S. Honda, S. Maeda, L. Chang, H. Hirata, and M. Karin. 2005. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120: 649-661.
17. Kinter, M., and R.J. Roberts. 1996. Glutathione consumption and glutathione peroxidase inactivation in fibroblast cell lines by 4-hydroxy-2-nonenal. Free Radical Biology and Medicine 21: 457-462.
18. Kooy, N.W., J.A. Royall, H. Ischiropoulos, and J.S. Beckman. 1994. Peroxynitrite-mediated oxidation of dihydrorhodamine 123. Free Radical Biology and Medicine 16: 149-156.
19. Kopp, E., and S. Ghosh. 1994. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265: 956-959.
20. Kwon, K.S., and H.J. Chae. 2003. Sodium salicylate inhibits expression of COX-2 through suppression of ERK and subsequent NF-kappaB activation in rat ventricular cardiomyocytes. Archives of Pharmacal Research 26: 545-553.
21. Lee, D.Y., Y.J. Oh, and B.K. Jin. 2005. Thrombin-activated microglia contribute to death of dopaminergic neurons in rat mesencephalic cultures: dual roles of mitogen-activated protein kinase signaling pathways. Glia 51: 98-110.
22. Lee, S.J., C.E. Kim, K.W. Seo, and C.D. Kim. 2010. HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages. Cardiovascular Research 88: 352-359.
23. Marletta, M.A. 1993. Nitric oxide synthase structure and mechanism. Journal of Biological Chemistry 268: 12231-12234.
24. Mercurio, F., and A.M. Manning. 1999. NF-kappaB as a primary regulator of the stress response. Oncogene 18: 6163-6171.
25. Nathan, C. 1992. Nitric oxide as a secretory product of mammalian cells. FASEB Journal 6: 3051-3064.
26. Nathan, C. 1997. Inducible nitric oxide synthase: what difference does it make? Journal of Clinical Investment 100: 2417-2423.
27. Ono, K., and J. Han. 2000. The p38 signal transduction pathway: activation and function. Cellular Signalling 12: 1-13.
28. Pelletier, J.P., J.C. Fernandes, D.V. Jovanovic, P. Reboul, and J. Martel-Pelletier. 2001. Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase. Journal of Rheumatology 28: 2509-2519.
29. Pryor, W.A., and G.L. Squadrito. 1995. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. American Journal of Physiology 268: L699-L722.
30. Rahman, I. 2002. Oxidative stress and gene transcription in asthma and chronic obstructive pulmonary disease: antioxidant therapeutic targets. Current Drug Targets: Inflammation and Allergy 1: 291-315.
31. Rubbo, H., R. Radi, M. Trujillo, R. Telleri, B. Kalyanaraman, S. Barnes, M. Kirk, and B.A. Freeman. 1994. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. Journal of Biological Chemistry 269: 26066-26075.
32. Santangelo, F. 2003. Intracellular thiol concentration modulating inflammatory response: influence on the regulation of cell functions through cysteine prodrug approach. Current Medicinal Chemistry 10: 2599-2610.
33. Schulze-Osthoff, K., D. Ferrari, K. Riehemann, and S. Wesselborg. 1997. Regulation of NF-kappa B activation by MAP kinase cascades. Immunobiology 198: 35-49.
34. Seo, J.Y., H. Kim, and K.H. Kim. 2002. Transcriptional regulation by thiol compounds in Helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells. Annals of the New York Academy of Sciences 973: 541-545.
35. Sheng, H., J. Shao, J.D. Morrow, R.D. Beauchamp, and R.N. Dubois. 1998. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Research 58: 362-366.
36. Stolina, M., S. Sharma, Y. Lin, M. Dohadwala, B. Gardner, J. Luo, L. Zhu, M. Kronenberg, P.W. Miller, J. Portanova, J.C. Lee, and S.M. Dubinett. 2000. Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis. Journal of Immunology 164: 361-370.
37. Tauskela, J.S., K. Hewitt, L.P. Kang, T. Comas, T. Gendron, A. Hakim, M. Hogan, J. Durkin, and P. Morley. 2000. Evaluation of glutathione-sensitive fluorescent dyes in cortical culture. Glia 30: 329-341.
38. Topper, J.N., J. Cai, D. Falb, and M.A. Gimbrone Jr. 1996. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proceedings of the National Academy of Sciences USA 93: 10417-10422.
39. Tran, P.O., C.E. Gleason, and R.P. Robertson. 2002. Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. Diabetes 51: 1772-1778.
40. Tsujii, M., S. Kawano, S. Tsuji, H. Sawaoka, M. Hori, and R.N. Dubois. 1998. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93: 705-716.
41. Van Der Woude, C.J., J.H. Kleibeuker, P.L. Jansen, and H. Moshage. 2004. Chronic inflammation, apoptosis and (pre-)malignant lesions in the gastro-intestinal tract. Apoptosis 9: 123-130.
42. Welch, B.D., N.G. Carlson, H. Shi, L. Myatt, and B.K. Kishore. 2003. P2Y2 receptor-stimulated release of prostaglandin E2 by rat inner medullary collecting duct preparations. American Journal of Physiology Renal Physiology 285: F711-F721.
43. Wheaton, K., P. Atadja, and K. Riabowol. 1996. Regulation of transcription factor activity during cellular aging. Biochemistry and Cell Biology 74: 523-534.
44. Xie, W.L., J.G. Chipman, D.L. Robertson, R.L. Erikson, and D.L. Simmons. 1991. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proceedings of National Academy of Sciences USA 88: 2692-2696.
45. Xu, X.M., L. Sansores-Garcia, X.M. Chen, N. Matijevic-Aleksic, M. Du, and K.K. Wu. 1999. Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. Proceedings of National Academy of Sciences USA 96: 5292-5297.