Synergistic effects of HB-EGF and mesenchymal stem cells in a murine model of intestinal ischemia/reperfusion injury

Journal of Pediatric Surgery

Volumn 48, Issue 6, 2013, Pages 1323-1329

  Watkins, Daniel J ^a,b,c   Yang, Jixin ^a,b,c   Matthews, Mika A B ^a,b,c   Besner, Gail E ^a,b,c  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Amniotic fluid; Bone marrow; Heparin binding EGF like growth factor; Intestinal injury; Ischemia reperfusion; Mesenchymal stem cells

Indexed keywords

HEPARIN BINDING EPIDERMAL GROWTH FACTOR;

AMNION FLUID; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE MARROW; CONFERENCE PAPER; ILEUM; INTESTINE ISCHEMIA; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY;

AMNIOTIC FLUID; BONE MARROW; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; INTESTINAL INJURY; ISCHEMIA/REPERFUSION; MESENCHYMAL STEM CELLS;

AMNIOTIC FLUID; ANIMALS; BONE MARROW CELLS; COMBINED MODALITY THERAPY; FEMALE; GASTROINTESTINAL AGENTS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINE, SMALL; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; MICE, INBRED C57BL; PROTECTIVE AGENTS; RANDOM ALLOCATION; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 84880024980     PISSN: 00223468     EISSN: 15315037     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2013.03.032     Document Type: Conference Paper

References (39)

1. M.F. Pittenger, A.M. Mackay, and S.C. Beck Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
2. H. Kawada, J. Fujita, and K. Kinjo Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction Blood 104 2004 3581 3587
3. M. Koda, S. Okada, and T. Nakayama Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice Neuroreport 16 2005 1763 1767
4. F. Togel, Z. Hu, and K. Weiss Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms Am J Physiol Renal Physiol 289 2005 F31 F42
5. J. Zhang, J.F. Gong, and W. Zhang Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice J Biomed Sci 15 2008 585 594
6. L. Wei, J.L. Fraser, and Z.Y. Lu Transplantation of hypoxia preconditioned bone marrow mesenchymal stem cells enhance angiogenesis and neurogenesis after cerebral ischemia in rats Neurobiol Dis 46 2012 635 645
7. Q. Yan, J.W. Ruan, and Y. Ding Electro-acupuncture promotes differentiation of mesenchymal stem cells, regeneration of nerve fibers and partial functional recovery after spinal cord injury Exp Toxicol Pathol 63 2011 151 156
8. C.Y. Wong, S.K. Cheong, and P.L. Mok Differentiation of human mesenchymal stem cells into mesangial cells in post-glomerular injury murine model Pathology 40 2008 52 57
9. A. Zarjou, J. Kim, and A.M. Traylor Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury requiresheme oxygenase-1 Am J Physiol Renal Physiol 300 2011 F254 F262
10. B.R. Weil, T.A. Markel, and J.L. Herrmann Mesenchymal stem cells enhance the viability and proliferation of human fetal intestinal epithelial cells following hypoxic injury via paracrine mechanisms Surgery 146 2009 190 197
11. D. Baksh, L. Song, and R.S. Tuan Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy J Cell Mol Med 8 2004 301 316
12. D.G. Phinney, G. Kopen, and R.L. Isaacson Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, differentiation J Cell Biochem 72 1999 570 585
13. E.M. Baghaban, S. Jahangir, and N. Aghdami Mesenchymal stem cells from murine amniotic fluid as a model for preclinical investigation Arch Iran Med 14 2011 96 103
14. D.M. Delo, P. De Coppi, and G. Bartsch Jr. Amniotic fluid and placental stem cells Methods Enzymol 419 2006 426 438
15. P. DeCoppi, G. Bartsch Jr., and M.M. Siddiqui Isolation of amniotic stem cell lines with potential for therapy Nat Biotechnol 25 2007 100 106
16. A. Peister, M.A. Woodruff, and J.J. Prince Cell sourcing for bone tissue engineering: amniotic fluid stem cells have a delayed, robust differentiation compared to mesenchymal stem cells Stem Cell Res 7 2011 17 27
17. G. Besner, S. Higashiyama, and M.P. Klasbrun Isolation and characterization of a macrophage-derived heparin-binding growth factor Cell Regul 1 1990 811 819
18. S. Higashiyama, J.A. Abraham, and J. Miller A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF Science 251 1991 936 939
19. V.B. Mehta, and G.E. Besner HB-EGF promotes angiogenesis in endothelial cells via PI3-kinase and MAPK signaling pathways Growth Factors 25 2007 253 263
20. O.N. El-Assal, H. Paddock, and A. Marquez Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice J Pediatr Surg 43 2008 1182 1190
21. O.N. El-Assal, A. Radulescu, and G.E. Besner Heparin-binding EGF-like growth factor preserves mesenteric microcirculatory blood flow and protects against intestinal injury in rats subjected to hemorrhagic shock and resuscitation Surgery 142 2007 234 242
22. X. Yu, A. Radulescu, and N. Zorko Heparin-binding EGF-like growth factor increases intestinal microvascular blood flow in necrotizing enterocolitis Gastroenterology 137 2009 221 230
23. C.L. Chen, X. Yu, and I.O. James Heparin-binding EGF-like growth factor protects intestinal stem cells from injury in a rat model of necrotizing enterocolitis Lab Invest 92 2012 331 334
24. D.J. Watkins, Y. Zhou, and C.L. Chen Heparin-binding EGF-like growth factor protects mesenchymal stem cells J Surg Res 177 2 2012 359 364
25. J. Yang, D.J. Watkins, and C.L. Chen Heparin-binding epidermal growth factor-like growth factor and mesenchymal stem cells act synergistically to prevent experimental necrotizing enterocolitis J Am Coll Surg 215 4 2012 534 545
26. C.J. Chiu, A.H. McArdle, and R. Brown Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal Arch Surg 101 1970 478 483
27. H. Zhang, A. Radulescu, and G.E. Besner Heparin-binding epidermal growth factor-like growth factor is essential for preservation of gut barrier function after hemorrhagic shock and resuscitation in mice Surgery 146 2009 334 339
28. K.M. Davis-Fleischer, and G.E. Besner Structure and function of heparin-binding EGF-like growth factor (HB-EGF) Front Biosci 3 1998 d288 d299
29. S. Tokumara, S. Higashiyama, and T. Endo Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing J Cell Biol 151 2000 209 220
30. R.J. Faull, J.M. Stanley, and S. Fraser HB-EGF is produced in the peritoneal cavity and enhances mesothelial cell adhesion and migration Kidney Int 59 2001 614 624
31. R.R. Beerli, and N.E. Hynes Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities J Biol Chem 271 1996 6071 6076
32. K. Elenius, S. Paul, and G. Allison Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation EMBO J 16 1997 1268 1278
33. E. Nishi, A. Prat, and V. Hospital N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration EMBO J 20 2001 3342 3350
34. V. Hospital, and A. Prat Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation Protein Pept Lett 11 2004 501 508
35. M. Krempera, A. Pasini, and A. Rigo HB-EGF/HER-1 signaling in bone marrow mesenchymal stem cells: inducing cell expansion and reversibly preventing multilineage differentiation Blood 106 2005 59 66
36. H. Ren, D. Accili, and C. Duan Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways Proc Natl Acad Sci U S A 107 2010 5857 5862
37. R. Xu, J. Chen, and X. Cong Lovastatin protects mesenchymal stem cells against hypoxi- and serum deprivation-induced apoptosis by activation of pi3k/akt and erk1/2 J Cell Biochem 103 2008 256 289
38. K.M. Peterson, A. Aly, and A. Lerman Improved survival of mesenchymal stromal cell after hypoxia preconditioning: role of oxidative stress Life Sci 88 2011 65 73
39. O.N. El-Assal, and G.E. Besner HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation Gastroenterology 129 2005 609 662