Promoter activity analysis and methylation characterization of LTR elements of PERVs in NIH miniature pig

Genes and Genetic Systems

Volumn 88, Issue 2, 2013, Pages 135-142

  Jung, Yi Deun ^a   Lee, Ja Rang ^a   Kim, Yun Ji ^b   Ha, Hong Seok ^a   Oh, Keon Bong ^c   Im, Gi Sun ^c   Choi, Bong Hwan ^c   Kim, Heui Soo ^a  

^a Pusan National University   (South Korea)

^b Dankook University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

Long terminal repeat (LTR); Methylation; Porcine endogenous retrovirus (PERV); Promoter activity; Transcription factor binding sites

Indexed keywords

TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR NKX2.2;

ANIMAL TISSUE; ARTICLE; BIOINFORMATICS; CONTROLLED STUDY; DNA METHYLATION; ENDOGENOUS RETROVIRUS; GENE LOCUS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIVER CELL; LONG TERMINAL REPEAT; MINIPIG; NONHUMAN; NUCLEOTIDE SEQUENCE; PORCINE ENDOGENOUS RETROVIRUS; PROMOTER REGION; SEQUENCE ANALYSIS;

ANIMALS; BASE SEQUENCE; DNA METHYLATION; ENDOGENOUS RETROVIRUSES; HEP G2 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; SEQUENCE HOMOLOGY, NUCLEIC ACID; SWINE; SWINE, MINIATURE; TERMINAL REPEAT SEQUENCES; TRANSCRIPTION, GENETIC; UNITED STATES;

PORCINE ENDOGENOUS RETROVIRUS; SUIDAE;

EID: 84880016518     PISSN: 13417568     EISSN: 18805779     Source Type: Journal    
DOI: 10.1266/ggs.88.135     Document Type: Article

References (51)

1. Akiyoshi, D. E., Denaro, M., Zhu, H., Greenstein, J. L., Banerjee, P., and Fishman, J. A. (1998) Identification of a full-length cDNA for an endogenous retrovirus of miniature swine. J. Virol. 72, 4503-4507.
2. Bernal-Mizrachi, E., Wen, W., Srinivasan, S., Klenk, A., Cohen, D., and Permutt, M. A. (2001) Activation of Elk-1, an Ets transcription factor, by glucose and EGF treatment of insulinoma cells. Am. J. Physiol. Endocrinol. Metab. 281, E1286-E1299.
3. Bittmann, I., Mihica, D., Plesker, R., and Denner, J. (2012) Expression of porcine endogenous retroviruses (PERV) in different organs of a pig. Virology 433, 329-336.
4. Blusch, J. H., Patience, C., Takeuchi, Y., Templin, C., Roos, C., Von Der Helm, K., Steinhoff, G., and Martin, U. (2000) Infection of nonhuman primate cells by pig endogenous retrovirus. J. Virol. 74, 7687-7690.
5. Blusch, J. H., Seelmeir, S., and von der Helm, K. (2002) Molecular and enzymatic characterization of the porcine endogenous retrovirus protease. J. Virol. 76, 7913-7917.
6. Boneva, R. S., Folks, T. M., and Chapman, L. E. (2001) Infectious disease issues in xenotransplantation. Clin. Microbiol. Rev. 14, 1-14.
7. Ceribelli, M., Dolfini, D., Merico, D., Gatta, R., Viganò, A. M., Pavesi, G., and Mantovani, R. (2008) The histone-like NF-Y is a bifunctional transcription factor. Mol. Cell. Biol. 28, 2047-2058.
8. Choy, M. K., Movassagh, M., Goh, H. G., Bennett, M. R., Down, T. A., and Foo, R. S. (2010) Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated. BMC Genomics 11, 519.
9. Costa, M. W., Lee, S., Furtado, M. B., Xin, L., Sparrow, D. B., Martinez, C. G., Dunwoodie, S. L., Kurtenbach, E., Mohun, T., Rosenthal, N., and Harvey, R. P. (2011) Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5. PLoS One 6, e24812.
10. Czauderna, F., Fischer, N., Boller, K., Kurth, R., and Tönjes, R. R. (2000) Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells. J. Virol. 74, 4028-4038.
11. Della Chiara, G., Crotti, A., Liboi, E., Giacca, M., Poli, G., and Lusic, M. (2011) Negative regulation of HIV-1 transcription by a heterodimeric NF-κB1/p50 and C-terminally truncated STAT5 complex. J. Mol. Biol. 410, 933-943.
12. Denner, J. (2007) Transspecies transmissions of retroviruses: new cases. Virology 369, 229-233.
13. Denner, J. (2008a) Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?. Arch. Virol. 153, 1421-1426.
14. Denner, J. (2008b) Is porcine endogenous retrovirus (PERV) transmission still relevant? Transplant. Proc. 40, 587-589.
15. Edamura, K., Nasu, K., Iwami, Y., Nishimura, R., Ogawa, H., Sasaki, N., and Ohgawara, H. (2004) Prevalence of porcine endogenous retrovirus in domestic pigs in Japan and its potential infection in dogs xenotransplanted with porcine pancreatic islet cells. J. Vet. Med. Sci. 66, 129-135.
16. Ericsson, T., Oldmixon, B., Blomberg, J., Rosa, M., Patience, C., and Andersson, G. (2001) Identification of novel porcine endogenous betaretrovirus sequences in miniature swine.J. Virol. 75, 2765-2770.
17. Flavell, A. J. (1999) Long terminal repeat retrotransposons jump between species. Proc. Natl. Acad. Sci. USA 96, 12211-12212.
18. Ha, H. S., Huh, J. W., Kim, D. S., Kang, D. W., Cho, B. W., and Kim, H. S. (2007) Promoter activity of the long terminal repeats of porcine endogenous retroviruses of the Korean domestic pig. Mol. Cells 24, 148-151.
19. Huh, J. W., Ha, H. S., Kim, Y. J., Lee, J. R., Kim, D. S., Cho, B. W., and Kim, H. S. (2007) Methylation and promoter activity of long terminal repeats from porcine endogenous retroviruses in the pig, Sus scrofa. Genes Genom. 29, 171-176.
20. Huh, J. W., Kim, D. S., Ha, H. S., Ahn, K., Chang, K. T., Cho, B. W., and Kim, H. S. (2009) Identification and molecular characterization of PERV gamma1 long terminal repeats. Mol. Cells 27, 119-123.
21. Jaenisch, R., and Bird, A. (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat. Genet. 33, 245-254.
22. Jin, H., Inoshima, Y., Wu, D., Morooka, A., and Sentsui, H. (2000) Expression of porcine endogenous retrovirus in peripheral blood leukocytes from ten different breeds. Transpl. Infect. Dis. 2, 11-14.
23. Jordan, I. K., Matyunina, L. V., and McDonald, J. F. (1999) Evidence for the recent horizontal transfer of long terminal repeat retrotransposon. Proc. Natl. Acad. Sci. USA 96, 12621-12625.
24. Jung, Y. D., Ha, H. S., Park, S. J., Oh, K. B., Im, G. S., Kim, T. H., Seong, H. H., and Kim, H. S. (2013) Identification and promoter analysis of PERV LTR subtypes in NIH-Miniature pig. Mol. Cells 35, 99-105.
25. Karlas, A., Irgang, M., Votteler, J., Specke, V., Ozel, M., Kurth, R., and Denner, J. (2010) Characterisation of a human cell-adapted porcine endogenous retrovirus PERV-A/C. Ann. Transplant. 15, 45-54.
26. Klymiuk, N., Müller, M., Brem, G., and Aigner, B. (2002) Characterization of porcine endogenous retrovirus γ pro-polnucleotide sequences. J. Virol. 76, 11738-11743.
27. Lavie, L., Kitova, M., Maldener, E., Meese, E., and Mayer, J. (2005) CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K (HML-2). J. Virol. 79, 876-883.
28. Lee, J. H., Webb, G. C., Allen, R. D., and Moran, C. (2002) Characterizing and mapping porcine endogenous retroviruses in Westran pigs. J. Virol. 76, 5548-5556.
29. Lee, Y. J., Park, S. H., Bae, E. H., and Jung, Y. T. (2012) Characterization of molecular clones of porcine endogenous retrovirus-A containing different numbers of U3 repeat boxes in the long terminal repeat region. J. Virol. Methods 181, 103-108.
30. Le Tissier, P., Stoye, J. P., Takeuchi, Y., Patience, C., and Weiss, R. A. (1997) Two sets of human-tropic pig retrovirus. Nature 389, 681-682.
31. Li, Z., Ping, Y., Shengfu, L., Hong, B., Youping, L., Yangzhi, Z., and Jingqiu, C. (2004) Phylogenetic relationship of porcine endogenous retrovirus (PERV) in Chinese pigs with some type C retroviruses. Virus Res. 105, 167-173.
32. Mang, R., Maas, J., Chen, X., Goudsmit, J., and van Der Kuyl, A. C. (2001) Identification of a novel type C porcine endogenous retrovirus: evidence that copy number of endogenous retroviruses increases during host inbreeding. J. Gen. Virol. 82, 1829-1834.
33. Martin, U., Kiessig, V., Blusch, J. H., Haverich, A., von der Helm, K., Herden, T., and Steinhoff, G. (1998) Expression of pig endogenous retrovirus by primary porcine endothelial cells and infection of human cells. Lancet 352, 692-694.
34. Marziali, G., Perrotti, E., Ilari, R., Coccia, E. M., Mantovani, R., Testa, U., and Battistini, A. (1999) The activity of the CCAAT-box binding factor NF-Y is modulated through the regulated expression of its A subunit during monocyte to macrophage differentiation: regulation of tissue-specific genes through a ubiquitous transcription factor. Blood 93, 519-526.
35. Mukerjee, R., Claudio, P. P., Chang, J. R., Del Valle, L., and Sawaya, B. E. (2010) Transcriptional regulation of HIV-1 gene expression by p53. Cell Cycle 9, 4569-4578.
36. Nascimento, F. F., Gongora, J., Charleston, M., Tristem, M., Lowden, S., and Moran, C. (2011) Evolution of endogenous retroviruses in the Suidae: evidence for different viral subpopulations in African and Eurasian host species. BMC Evol. Biol. doi: 10.1186/1471-2148-11-139.
37. Niebert, M., Rogel-Gaillard, C., Chardon, P., and Tönjes, R. R. (2002) Characterization of chromosomally assigned replication-competent gamma porcine endogenous retroviruses derived from a large white pig and expression in human cells. J. Virol. 76, 2714-2720.
38. Park, S. J., Huh, J. W., Kim, D. S., Ha, H. S., Jung, Y. D., Ahn, K., Oh, K. B., Park, E. W., Chang, K. T., and Kim, H. S. (2010) Analysis of the molecular and regulatory properties of active porcine endogenous retrovirus gamma-1 long terminal repeats in kidney tissues of the NIH-Miniature pig. Mol. Cells 30, 319-325.
39. Patience, C., Takeuchi, Y., and Weiss, R. A. (1997) Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. 3, 282-286.
40. Patience, C., Switzer, W. M., Takeuchi, Y., Griffiths, D. J., Goward, M. E., Heneine, W., Stoye, J. P., and Weiss, R. A. (2001) Multiple groups of novel retroviral genomes in pigs and related species. J. Virol. 75, 2771-2775.
41. Piskurek, O., and Okada, N. (2007) Poxviruses as possible vectors for horizontal transfer of retroposons from reptiles to mammals. Proc. Natl. Acad. Sci. USA 104, 12046-12051.
42. Powell, S. K., Gates, M. E., Langford, G., Gu, M. L., Lockey, C., Long, Z., and Otto, E. (2000) Antiretroviral agents inhibit infection of human cells by porcine endogenous retroviruses. Antimicrob. Agents Chemother. 44, 3432-3433.
43. Qari, S. H., Magre, S., García-Lerma, J. G., Hussain, A. I., Takeuchi, Y., Patience, C., Weiss, R. A., and Heneine, W. (2001) Susceptibility of the porcine endogenous retrovirus to reverse transcriptase and protease inhibitors. J. Virol. 75, 1048-1053.
44. Quinn, G., and Langford, G. (2001) The porcine endogenous retrovirus long terminal repeat contains a single nucleotide polymorphism that confers distinct differences in estrogen receptor binding affinity between PERV A and PERV B/C subtypes. Virology 286, 83-90.
45. Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C., Schreiber, S. L., Mellor, J., and Kouzarides, T. (2002) Active genes are tri-methylated at K4 of histone H3. Nature 419, 407-411.
46. Scheef, G., Fischer, N., Krach, U., and Tönjes, R. R. (2001) The number of a U3 repeat box acting as an enhancer in long terminal repeats of polytropic replication-competent porcine endogenous retroviruses dynamically fluctuates during serial virus passages in human cells. J. Virol. 75, 6933-6940.
47. Takeuchi, Y., Patience, C., Magre, S., Weiss, R. A., Banerjee, P. T., Le Tissier, P., and Stoye, J. P. (1998) Host range and interference studies of three classes of pig endogenous retrovirus. J. Virol. 72, 9986-9991.
48. Wilson, C. A. (2008) Porcine endogenous retroviruses and xenotransplantation. Cell. Mol. Life Sci. 65, 3399-3412.
49. Wilson, C. A., Wong, S., Muller, J., Davidson, C. E., Rose, T. M., and Burd, P. (1998) Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J. Virol. 72, 3082-3087.
50. Wood, J. C., Quinn, G., Suling, K. M., Oldmixon, B. A., Van Tine, B. A., Cina, R., Arn, S., Huang, C. A., Scobie, L., Onions, D. E., et al. (2004) Identification of exogenous forms of human-tropic porcine endogenous retrovirus in miniature swine. J. Virol. 78, 2494-2501.
51. Yu, S. L., Jung, W. Y., Jung, K. C., Cho, I. C., Lim, H. T., Jin, D. I., and Lee, J. H. (2012) Characterization of porcine endogenous retrovirus clones from the NIH miniature pig BAC library. J. Biomed. Biotechnol. doi: 10.1155/2012/482568.