Negative regulation of p53 by ras superfamily protein RBEL1A

Journal of Cell Science

Volumn 126, Issue 11, 2013, Pages 2436-2445

  Lui, Ki ^a,b   An, Jie ^a   Montalbano, JoAnne ^a   Shi, Jingxue ^a   Corcoran, Chad ^a   He, Qin ^a   Sun, Hong ^a   Sheikh, M Saeed ^a   Huang, Ying ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

GTPase; MDM2; P53 tumor suppressor; Ras superfamily; Ubiquitylation

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEIN MDM2; PROTEIN P53; RAS PROTEIN; RBEL1A PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENOTOXICITY; HALF LIFE TIME; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; UBIQUITINATION;

GTPASE; MDM2; P53 TUMOR SUPPRESSOR; UBIQUITYLATION, RAS SUPERFAMILY;

ANIMALS; CELL LINE, TUMOR; DNA DAMAGE; HUMANS; MICE; MICE, KNOCKOUT; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MDM2; RAS PROTEINS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84880012546     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.118117     Document Type: Article

References (24)

1. Baumbusch, L. O., Myhre, S., Langerød, A., Bergamaschi, A., Geisler, S. B., Lønning, P. E., Deppert, W., Dornreiter, I. and Børresen-Dale, A. L. (2006). Expression of full-length p53 and its isoform Deltap53 in breast carcinomas in relation to mutation status and clinical parameters. Mol. Cancer 5, 47.
2. Buchhop, S., Gibson, M. K., Wang, X. W., Wagner, P., Stürzbecher, H. W. and Harris, C. C. (1997). Interaction of p53 with the human Rad51 protein. Nucleic Acids Res. 25, 3868-3874.
3. Corcoran, C. A., Huang, Y. and Sheikh, M. S. (2004). The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest. Cancer Biol. Ther. 3, 721-725.
4. Corcoran, C. A., Montalbano, J., Sun, H., He, Q., Huang, Y. and Sheikh, M. S. (2009). Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains. J. Biol. Chem. 284, 21955-21970.
5. Dobbelstein, M., Wienzek, S., König, C. and Roth, J. (1999). Inactivation of the p53- homologue p73 by the mdm2-oncoprotein. Oncogene 18, 2101-2106.
6. Hofmann, T. G., Möller, A., Sirma, H., Zentgraf, H., Taya, Y., Dröge, W., Will, H. and Schmitz, M. L. (2002). Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat. Cell Biol. 4, 1-10.
7. Jiang, L., Sheikh, M. S. and Huang, Y. (2010). Decision making by p53: Life versus death. Mol. Cell Pharmacol. 2, 69-77.
8. Kussie, P. H., Gorina, S., Marechal, V., Elenbaas, B., Moreau, J., Levine, A. J. and Pavletich, N. P. (1996). Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274, 948-953.
9. Lane, D. P., Cheok, C. F. and Lain, S. (2010). p53-based cancer therapy. Cold Spring Harb. Perspect. Biol. 2, a001222.
10. Li, B., Cheng, Q., Li, Z. and Chen, J. (2010). p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors. Cell Cycle 9, 1411-1420.
11. Lin, J., Chen, J., Elenbaas, B. and Levine, A. J. (1994). Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 8, 1235-1246.
12. Livak, K. J. and Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408.
13. Lui, K., Huang, Y., Choi, H. L., Yu, S., Wong, K. B., Chen, S. and Chan, F. L. (2006). Molecular cloning and functional study of rat estrogen receptor-related receptor gamma in rat prostatic cells. Prostate 66, 1600-1619.
14. Luo, X., Huang, Y. and Sheikh, M. S. (2003). Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation. Oncogene 22, 7247-7257.
15. Luo, X., He, Q., Huang, Y. and Sheikh, M. S. (2005). Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulinbinding IQ motif protein and is up-regulated in gastrointestinal cancers. Cancer Res. 65, 10725-10733.
16. Meek, D. W. and Anderson, C. W. (2009). Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb. Perspect. Biol. 1, a000950.
17. Montalbano, J., Jin, W., Sheikh, M. S. and Huang, Y. (2007). RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer. J. Biol. Chem. 282, 37640-37649.
18. Montalbano, J., Lui, K., Sheikh, M. S. and Huang, Y. (2009). Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation. J. Biol. Chem. 284, 18129-18142.
19. Riley, T., Sontag, E., Chen, P. and Levine, A. (2008). Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 9, 402-412.
20. Rong, R., Jiang, L. Y., Sheikh, M. S. and Huang, Y. (2007). Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation. Oncogene 26, 7700-7708.
21. Shangary, S. and Wang, S. (2009). Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. Annu. Rev. Pharmacol. Toxicol. 49, 223-241.
22. Sui, G., Affar, B., Shi, Y., Brignone, C., Wall, N. R., Yin, P., Donohoe, M., Luke, M. P., Calvo, D., Grossman, S. R. et al. (2004). Yin Yang 1 is a negative regulator of p53. Cell 117, 859-872.
23. Vassilev, L. T. (2007). MDM2 inhibitors for cancer therapy. Trends Mol. Med. 13, 23-31.
24. Zilfou, J. T. and Lowe, S. W. (2009). Tumor suppressive functions of p53. Cold Spring Harb. Perspect. Biol. 1, a001883.