Both total testosterone and sex hormone-binding globulin are independent risk factors for metabolic syndrome: Results from fangchenggang area male health and examination survey in china

Diabetes/Metabolism Research and Reviews

Volumn 29, Issue 5, 2013, Pages 391-397

  Zhang, Jiange ^a,b   Huang, Xianghua ^b   Liao, Ming ^a,c   Gao, Yong ^a,c   Tan, Aihua ^c   Yang, Xiaobo ^c   Zhang, Haiying ^c   Mo, Linjian ^a,c   Zhang, Youjie ^a,c   Lu, Zheng ^a,c   Wu, Chunlei ^a,c   Hu, Yanling ^c   Mo, Zengnan ^a,c  

^a FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^b Guigang People's Hospital   (China)

^c GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Body mass index; Chinese male population; Insulin resistance; Metabolic syndrome; Sex hormone binding globulin; Testosterone

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGE; AGED; ARTICLE; BODY MASS; CHINA; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DIET RESTRICTION; DISEASE ASSOCIATION; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HORMONE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SMOKING; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

BODY MASS INDEX; CHINESE MALE POPULATION; INSULIN RESISTANCE; METABOLIC SYNDROME; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; BODY MASS INDEX; CHINA; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DOWN-REGULATION; HEALTH SURVEYS; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PREVALENCE; RISK FACTORS; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE; YOUNG ADULT;

EID: 84880000450     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.2405     Document Type: Article

References (36)

1. Bhasin S, Jasjua GK, Pencina M, et al. Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the framingham heart study. Diabetes Care 2011; 34(11): 2464-2470.
2. Bhattacharya RK, Khera M, Blick G, Kushner H, Nguyen D, Miner MM. Effect of 12months of testosterone replacement therapy on metabolic syndrome components in hypogonadal men: data from the Testim Registry in the US (TRiUS). BMC endocrine disorders 2011; 11(1): 18.
3. Corona G, Monami M, Rastrelli G, et al. Testosterone and metabolic syndrome: a meta-analysis study. J Sex Med 2011; 8(1): 272-283.
4. Jeong SM, Ham BK, Park MG, et al. Effect of testosterone replacement treatment in testosterone deficiency syndrome patients with metabolic syndrome. Korean journal of urology 2011; 52(8): 566-571.
5. Jones TH. Effects of testosterone on type 2 diabetes and components of the metabolic syndrome. J Diabetes 2010; 2(3): 146-156.
6. Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metabol 2004; 89(7): 3313-3318.
7. Singh SK, Goyal R, Pratyush DD. Is hypoandrogenemia a component of metabolic syndrome in males? Experimental and Clinical Endocrinology & Diabetes: Official Journal, German Society of Endocrinology [and] German Diabetes Association 2011; 119(1): 30-35.
8. Kaufman JM, Vermeulen A. The decline of androgen levels in elderly men and its clinical and therapeutic implications. Endocr Rev 2005; 26(6): 833-876.
9. Laaksonen DE, Niskanen L, Punnonen K, et al. Sex hormones, inflammation and the metabolic syndrome: a population-based study. European Journal of Endocrinology/European Federation of Endocrine Societies 2003; 149(6): 601-608.
10. Singh R, Artaza JN, Taylor WE, Gonzalez-Cadavid NF, Bhasin S. Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway. Endocrinology 2003; 144(11): 5081-5088.
11. Kapoor D, Malkin CJ, Channer KS, Jones TH. Androgens, insulin resistance and vascular disease in men. Clin Endocrinol 2005; 63(3): 239-250.
12. Lacko L, Wittke B, Geck P. Interaction of steroids with the transport system of glucose in human erythrocytes. J Cell Physiol 1975; 86 Suppl 2(3 Pt 2): 673-680.
13. Laaksonen DE, Niskanen L, Punnonen K, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care 2004; 27(5): 1036-1041.
14. Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metabol 2006; 91(3): 843-850.
15. Li C, Ford ES, Li B, Giles WH, Liu S. Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care 2010; 33(7): 1618-1624.
16. Chubb SA, Hyde Z, Almeida OP, et al. Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study. European journal of endocrinology/European Federation of Endocrine Societies 2008; 158(6): 785-792.
17. Liao CH, Huang CY, Li HY, Yu HJ, Chiang HS, Liu CK. Testosterone and sex hormone-binding globulin have significant association with metabolic syndrome in Taiwanese men. The Aging Male: the Official Journal of the International Society for the Study of the Aging Male 2012; 15(1): 1-6.
18. Haring R, Volzke H, Spielhagen C, Nauck M, Wallaschofski H. The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome. European Journal of Preventive Cardiology 2012 [Epub ahead of print].
19. Osuna JA, Gomez-Perez R, Arata-Bellabarba G, Villaroel V. Relationship between BMI, total testosterone, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men. Arch Androl 2006; 52(5): 355-361.
20. Tan A, Gao Y, Yang X, et al. Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey. Metabolism 2011; 60(8): 1186-1192.
21. Shiels MS, Rohrmann S, Menke A, et al. Association of cigarette smoking, alcohol consumption, and physical activity with sex steroid hormone levels in US men. Cancer Causes & Control: CCC 2009; 20(6): 877-886.
22. Craig CL, Marshall AL, Sjostrom M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35(8): 1381-1395.
23. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metabol 1999; 84(10): 3666-3672.
24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28(7): 412-419.
25. Maggio M, Lauretani F, Ceda GP, Bandinelli S, Basaria S, Ble A, Egan J, Paolisso G, Najjar S, Jeffrey Metter E, et al. Association between hormones and metabolic syndrome in older Italian men. J Am Geriatr Soc 2006; 54(12): 1832-1838.
26. Muller M, Grobbee DE, den Tonkelaar I, Lamberts SW, van der Schouw YT. Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endocrinol Metabol 2005; 90(5): 2618-2623.
27. Kupelian V, Hayes FJ, Link CL, Rosen R, McKinlay JB. Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metabol 2008; 93(9): 3403-3410.
28. Muller M, den Tonkelaar I, Thijssen JH, Grobbee DE, van der Schouw YT. Endogenous sex hormones in men aged 40-80 years. European Journal Of Endocrinology/European Federation of Endocrine Societies 2003; 149(6): 583-589.
29. Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metabol 2002; 87(2): 589-598.
30. Singh R, Artaza JN, Taylor WE, et al. Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 2006; 147(1): 141-154.
31. Demirbag R, Yilmaz R, Erel O. The association of total antioxidant capacity with sex hormones. Scandinavian Cardiovascular Journal: SCJ 2005; 39(3): 172-176.
32. Morimoto S, Mendoza-Rodriguez CA, Hiriart M, Larrieta ME, Vital P, Cerbon MA. Protective effect of testosterone on early apoptotic damage induced by streptozotocin in rat pancreas. J Endocrinol 2005; 187(2): 217-224.
33. Rubinow KB, Snyder CN, Amory JK, Hoofnagle AN, Page ST. Acute testosterone deprivation reduces insulin sensitivity in men. Clin Endocrinol 2012; 76(2): 281-288.
34. Gooren LJ. The age-related decline of androgen levels in men: clinically significant? Br J Urol 1996; 78(5): 763-768.
35. Rosner W, Hryb DJ, Khan MS, Nakhla AM, Romas NA. Sex hormone-binding globulin: anatomy and physiology of a new regulatory system. J Steroid Biochem Mol Biol 1991; 40(4-6): 813-820.
36. Mohr BA, Bhasin S, Link CL, O'Donnell AB, McKinlay JB. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. European Journal Of Endocrinology/European Federation of Endocrine Societies 2006; 155(3): 443-452.