The age-related decline of androgen levels in men: Clinically significant?

British Journal of Urology

Volumn 78, Issue 5, 1996, Pages 763-768

  Gooren, L J G ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Ageing; Androgens; Testosterone supplementation

Indexed keywords

ANDROGEN;

AGE; AGING; ANDROGEN BLOOD LEVEL; CLIMACTERIUM; HUMAN; MALE; NOMENCLATURE; PRIORITY JOURNAL; REVIEW; TESTIS;

EID: 0030420271     PISSN: 00071331     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-410x.1996.05918.x     Document Type: Review

References (49)

1. Boreil M. Brown-Sequard's organotherapy and its appearance in America at the end of the nineteenth century. Bull Hist Med 1976: 50: 309-20
2. Benjamin H. Eugen Steinach, 1861-1944: a life of research. Sci Monthly 1945; 61: 427-42
3. Lock S. 0 that I were young again: Yeats and the Steinach operation. Er Med J 1983: 287: 1964-8
4. Sengoopta C. Rejuvenation and the prolongation of life: science or quackery? Perspect Biol Med 1993: 37: 55-66
5. Werner AA. The male climacteric. JAMA 1939: 112: 1441-3
6. Werner AA. The male climacteric. Report of two hundred and seventy-three cases. JAMA 1946: 132: 188-94
7. Heller CG, Myers GB. The male climacteric, its symptomatology, diagnosis and treatment. JAMA 1944; 126: 472-7
8. Bauer J. The male climacteric -a misnomer. Letter to the editor. JAMA 1944; 126: 914
9. Hollander N. Hollander VP. The microdetermination of testosterone in human spermatic vein blood. J Clin Endocrinol Metab 1958; 18: 966-70
10. Vermeulen A. Testosterone excretion, plasma testosterone levels and testosterone production rates in health and disease. In James VHT ed. Testosterone, Proc of Workshop Conference Temsbuttel 1967: 170-5
11. Nieschlag E, Kley KH. Wiegelmann W, Solbach HG, Kruskemper HL. Lebensalter und endokrine Funktion der Testes der erwachsenen Mannes. Dtsch Med Wochenschr 1973; 98: 1281-4
12. Harman SM, Tsitouras PD. Reproductive hormones in aging men. Measurements of sex steroids, basal luteinizing hormone and Leydig cell response to human chorionic gonadotropin. J Clin Endocrinol Metab 1980: 51: 35-40
13. Nieschlag E. Lammers U, Freischem CW, Langer K. Wickings EJ. Reproductive function in young fathers and grandfathers. J Clin Endocrinol Metab 1982; 555: 676-81
14. Deslypere JP. Vermeulen A. Leydig cell function in normal men: effect of age, life style, residence, diet and activity. J Clin Endocrinol Metab 1984; 59: 955-62
15. Gray A, Feldman A, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991; 73: 1016-25
16. Simon D, Preziosi P, Barrett-Connor E et al. The influence of aging on plasma sex hormones in men: the Telecom study. Am J Epidemiol 1992; 135: 783-91
17. Pazzagli M, Forti G, Cappaleni A et al. Radioimmunoassay of dihydrotestosterone in normal and hypogonadal men. Clin Endocrinol (Oxf) 1975; 4: 513-7
18. Pirke KM, Doerr P. Age related changes in free plasma testosterone, dihydrotestosterone and oestradiol. Acta Endocrinol 1975; 74: 792-800
19. Bremner WJ, Vitiello MV, Prinz. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983; 56: 1278-81
20. Deslypere JP, Vermeulen A. Aging and tissue androgens. J Clin Endocrinol Metab 1981; 53: 430-4
21. Korenman SG, Morley JE, Mooradian AD et al. Secondary hypogonadism in older men: Its relation to impotence. J Clin Endocrinol Metab 1990; 71: 963-9
22. Mitchell R, Hollis S, Rothweil C, Robertson R. Age related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive drive. Clin Endocrinol 1995; 42: 501-7
23. Johnson L. Spermatogenesis and aging in the human male. J Androl 1986; 7: 331-54
24. Suoranta H. Changes in small blood vessels of the adult human testis in relation to age: some pathological conditions. Virchows Archiv (Path Anat) 1971; 352: 765-81
25. Vermeulen A, Deslypere JP. Intratesticular conjugated steroids in elderly men. J Steroid Biochem 1986; 24: 1079-83
26. Nahoul K, Roger M. Age relate decline of plasma bioavailable testosterone in adult men. J Steroid Biochem Mol Biol 1990; 35: 293-9
27. Handelsman DJ. Testicular dysfunction in systemic disease. Endocrinol Metab Clin North Am 1994; 23: 839-56
28. Deslypere JP, Vermeulen A. Influence of age on steroid concentrations in skin and striated muscle in women and cardiac muscle and lung tissue in men. J Clin Endocrinol Metab 1985; 60: 648-53
29. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54-61
30. Mulligan T. Why aged men become impotent. Arch Intern Med 1989; 149: 1365-6
31. Schiavi RC, Schreiner-Engel P, White D, Mandeli J. The relationship between pituitary-gonadal function and sexual behavior in healthy aging men. Psychosom Med 1991; 55: 363-74
32. Bancroft J. Human sexuality and its problems. Edinburgh: Churchill Livingstone 1989: 89-102
33. Gooren LJG. Androgen levels and sex functions in testosterone treated hypogonadal men. Arch Sex Behav 1987; 16: 463-73
34. Santavirtas, KonttinenYT, Heliovaara M, Knekt P, Luthje P, Aromaa A. Determinants of osteoporotic thoracic vertebral fracture -Screening of 5 7 000 Finnish women and men. Acta Orthoped Scand 1992; 63: 198-202
35. 5 Finkelstein JS, Klibanski A, Neer RM et al. Increase in bone density during treatment of men with idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 1989; 69: 776-83
36. Swerdloff RS, Wang C. Androgen deficiency and aging in men. West J Med 1993; 159: 579-85
37. Tenover JS. Androgen administration to aging men. Endocrinol Metab Clin North Am 1994; 23: 877-92
38. Morley JE, Perry HM, Kaiser FE et al. Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 1993; 41: 149-52
39. Tenover JS. Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992; 75: 1092-8
40. Marin P, Holmung S, Jonsson T et al. The effects of testosterone on body composition and metabolism in middle-aged obese men. Int J Obes 1992; 16: 991-7
41. Phillips GB, Pinkernell BH, Jing T-Y. The association between hypotesteronemia and coronary artery disease in men. Arterioscer Thromb 1994; 14: 701-6
42. Carry PJ, Goodwin JS, Hunt WC. Iron status and anemia in the elderly. J Am Geriatr Soc 1983; 31: 389-92
43. Polderman KH, Gooren LJG, Asscheman H, Bakker A, Heine RJ. Induction of insulin resistance by androgens and estrogens. J Clin Endocrinol Metab 1994; 79: 275-81
44. Polderman KH, Stehouwer CDA, Van de Kamp GJ, Dekker GA, Verbeugt FWA, Gooren LJG. Influence of sex hormones on plasma endothelin levels. Ann Int Med 1993; 118: 429-32
45. Wallace EM, Pye SD, Wildt SR, Wu FC. Prostate specific antigen and prostate gland size in men receiving exogenous testosterone for male contraception. Int J Androl 1993; 16: 35-40
46. Behre HM, Bohmeyer J, Nieschlag E. Prostate volume in testosterone-treated and untreated hypogonadal men compared to age-matched normal subjects. Clin Endocrinol 1994; 40: 341-9
47. Holmäng S, Marin P, Lindtstedt G, Hedelin H. Effect of long-term oral testosterone undecanoate treatment on prostate volume and serum prostate specific antigen in eugonadal middle-aged men. Prostate 1993; 23: 99-106
48. Handelsman DJ, Conway AJ, Boylan LM. Pharmacokinetics and pharmacodynamics of testosterone pellets in man. J Clin Endocrinol Metab 1990; 71: 216-20
49. Kumar N, Didolkar AK, Monder C, Bardin CW, Sundaram K. The biological activity of 7-methyl-19-nortestosterone is not amplified in the male reproductive tract as is that of testosterone. Endocrinology 1992; 130: 3677-83