TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress

Journal of Neurochemistry

Volumn 126, Issue 2, 2013, Pages 288-300

  Higashi, Shinji ^a,b   Kabuta, Tomohiro ^a   Nagai, Yoshitaka ^a   Tsuchiya, Yukihiro ^a   Akiyama, Haruhiko ^b   Wada, Keiji ^a  

^a NATIONAL INSTITUTE OF NEUROSCIENCE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

amyotrophic lateral sclerosis; apoptosis; frontotemporal lobar degeneration; oxidative stress; stress granule; TDP 43

Indexed keywords

ARSENITE SODIUM; DISULFIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYADENYLATED RNA; PROTEIN P62; STRESS ACTIVATED PROTEIN KINASE; TAR DNA BINDING PROTEIN;

ARTICLE; BIOCHEMISTRY; CELL CULTURE; CELL DAMAGE; CELL GRANULE; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; GENE SILENCING; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RIBOSOME; RNA BINDING; RNA STABILITY; STEADY STATE; TRANSLATION REGULATION;

AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; FRONTOTEMPORAL LOBAR DEGENERATION; OXIDATIVE STRESS; STRESS GRANULE; TDP-43;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ARSENITES; CASPASE 1; CELL LINE; CELL SURVIVAL; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; OXIDATIVE STRESS; PROTEIN STRUCTURE, TERTIARY; RIBOSOMES; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SODIUM COMPOUNDS; TIME FACTORS; TRANSFECTION;

EID: 84879984491     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12194     Document Type: Article

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