-
1
-
-
79954999150
-
Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review
-
Mandenius CF, Steel D, Noor F, Meyer T, Heinzle E, et al. (2011) Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol 31: 191-205.
-
(2011)
J Appl Toxicol
, vol.31
, pp. 191-205
-
-
Mandenius, C.F.1
Steel, D.2
Noor, F.3
Meyer, T.4
Heinzle, E.5
-
2
-
-
84859641526
-
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG
-
Jonsson MK, Vos MA, Mirams GR, Duker G, Sartipy P,et al. (2012) Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. J Mol Cell Cardiol.
-
(2012)
J Mol Cell Cardiol
-
-
Jonsson, M.K.1
Vos, M.A.2
Mirams, G.R.3
Duker, G.4
Sartipy, P.5
-
3
-
-
84879958431
-
Cardiotoxicity of cancer therapeutics: current issues in screening, prevention, and therapy
-
Sheppard RJ, Berger J, Sebag IA, (2013) Cardiotoxicity of cancer therapeutics: current issues in screening, prevention, and therapy. Front Pharmacol 4: 19.
-
(2013)
Front Pharmacol
, vol.4
, pp. 19
-
-
Sheppard, R.J.1
Berger, J.2
Sebag, I.A.3
-
4
-
-
0035145286
-
Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers
-
Lu HR, Marien R, Saels A, De Clerck F, (2001) Species plays an important role in drug-induced prolongation of action potential duration and early afterdepolarizations in isolated Purkinje fibers. J Cardiovasc Electrophysiol 12: 93-102.
-
(2001)
J Cardiovasc Electrophysiol
, vol.12
, pp. 93-102
-
-
Lu, H.R.1
Marien, R.2
Saels, A.3
De Clerck, F.4
-
5
-
-
79951496281
-
Cardiomyocyte clusters derived from human embryonic stem cells share similarities with human heart tissue
-
Asp J, Steel D, Jonsson M, Ameen C, Dahlenborg K, et al. (2010) Cardiomyocyte clusters derived from human embryonic stem cells share similarities with human heart tissue. J Mol Cell Biol 2: 276-283.
-
(2010)
J Mol Cell Biol
, vol.2
, pp. 276-283
-
-
Asp, J.1
Steel, D.2
Jonsson, M.3
Ameen, C.4
Dahlenborg, K.5
-
6
-
-
84872245899
-
Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF
-
Ye L, Zhang S, Greder L, Dutton J, Keirstead SA, et al. (2013) Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF. PLoS One 8: e53764.
-
(2013)
PLoS One
, vol.8
-
-
Ye, L.1
Zhang, S.2
Greder, L.3
Dutton, J.4
Keirstead, S.A.5
-
7
-
-
79954543387
-
A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability
-
Burridge PW, Thompson S, Millrod MA, Weinberg S, Yuan X, et al. (2011) A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability. PLoS One 6: e18293.
-
(2011)
PLoS One
, vol.6
-
-
Burridge, P.W.1
Thompson, S.2
Millrod, M.A.3
Weinberg, S.4
Yuan, X.5
-
8
-
-
52949109296
-
Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells
-
Synnergren J, Akesson K, Dahlenborg K, Vidarsson H, Ameen C, et al. (2008) Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells. Stem Cells 26: 1831-1840.
-
(2008)
Stem Cells
, vol.26
, pp. 1831-1840
-
-
Synnergren, J.1
Akesson, K.2
Dahlenborg, K.3
Vidarsson, H.4
Ameen, C.5
-
9
-
-
84857762746
-
Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue
-
Synnergren J, Ameen C, Jansson A, Sartipy P, (2012) Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue. Physiol Genomics 44: 245-258.
-
(2012)
Physiol Genomics
, vol.44
, pp. 245-258
-
-
Synnergren, J.1
Ameen, C.2
Jansson, A.3
Sartipy, P.4
-
10
-
-
58449092608
-
Cardiomyocytes derived from human embryonic stem cells - characteristics and utility for drug discovery
-
Steel D, Hyllner J, Sartipy P, (2009) Cardiomyocytes derived from human embryonic stem cells- characteristics and utility for drug discovery. Curr Opin Drug Discov Devel 12: 133-140.
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 133-140
-
-
Steel, D.1
Hyllner, J.2
Sartipy, P.3
-
11
-
-
65549134641
-
Local control of excitation-contraction coupling in human embryonic stem cell-derived cardiomyocytes
-
Zhu WZ, Santana LF, Laflamme MA, (2009) Local control of excitation-contraction coupling in human embryonic stem cell-derived cardiomyocytes. PLoS One 4: e5407.
-
(2009)
PLoS One
, vol.4
-
-
Zhu, W.Z.1
Santana, L.F.2
Laflamme, M.A.3
-
12
-
-
77949293236
-
Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications
-
Vidarsson H, Hyllner J, Sartipy P, (2010) Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications. Stem Cell Rev 6: 108-120.
-
(2010)
Stem Cell Rev
, vol.6
, pp. 108-120
-
-
Vidarsson, H.1
Hyllner, J.2
Sartipy, P.3
-
13
-
-
83755172797
-
Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes
-
Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, et al. (2012) Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes. Br J Pharmacol 165: 467-478.
-
(2012)
Br J Pharmacol
, vol.165
, pp. 467-478
-
-
Nalos, L.1
Varkevisser, R.2
Jonsson, M.K.3
Houtman, M.J.4
Beekman, J.D.5
-
14
-
-
77952253259
-
Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs
-
Otsuji TG, Minami I, Kurose Y, Yamauchi K, Tada M, et al. (2010) Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs. Stem Cell Res 4: 201-213.
-
(2010)
Stem Cell Res
, vol.4
, pp. 201-213
-
-
Otsuji, T.G.1
Minami, I.2
Kurose, Y.3
Yamauchi, K.4
Tada, M.5
-
15
-
-
23944486374
-
Cells on a chip-the use of electric properties for highly sensitive monitoring of blood-derived factors involved in angiotensin II type 1 receptor signalling
-
Rothermel A, Kurz R, Ruffer M, Weigel W, Jahnke HG, et al. (2005) Cells on a chip-the use of electric properties for highly sensitive monitoring of blood-derived factors involved in angiotensin II type 1 receptor signalling. Cell Physiol Biochem 16: 51-58.
-
(2005)
Cell Physiol Biochem
, vol.16
, pp. 51-58
-
-
Rothermel, A.1
Kurz, R.2
Ruffer, M.3
Weigel, W.4
Jahnke, H.G.5
-
16
-
-
76749151845
-
Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
-
Braam SR, Tertoolen L, van de Stolpe A, Meyer T, Passier R, et al. (2010) Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res 4: 107-116.
-
(2010)
Stem Cell Res
, vol.4
, pp. 107-116
-
-
Braam, S.R.1
Tertoolen, L.2
van de Stolpe, A.3
Meyer, T.4
Passier, R.5
-
17
-
-
34247877635
-
Effect of cardioactive drugs on action potential generation and propagation in embryonic stem cell-derived cardiomyocytes
-
Reppel M, Igelmund P, Egert U, Juchelka F, Hescheler J, et al. (2007) Effect of cardioactive drugs on action potential generation and propagation in embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 19: 213-224.
-
(2007)
Cell Physiol Biochem
, vol.19
, pp. 213-224
-
-
Reppel, M.1
Igelmund, P.2
Egert, U.3
Juchelka, F.4
Hescheler, J.5
-
18
-
-
41549135210
-
Microcavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue models
-
Kloss D, Kurz R, Jahnke HG, Fischer M, Rothermel A, et al. (2008) Microcavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue models. Biosens Bioelectron 23: 1473-1480.
-
(2008)
Biosens Bioelectron
, vol.23
, pp. 1473-1480
-
-
Kloss, D.1
Kurz, R.2
Jahnke, H.G.3
Fischer, M.4
Rothermel, A.5
-
19
-
-
64449085887
-
A microelectrode-based sensor for label-free in vitro detection of ischemic effects on cardiomyocytes
-
Krinke D, Jahnke HG, Panke O, Robitzki AA, (2009) A microelectrode-based sensor for label-free in vitro detection of ischemic effects on cardiomyocytes. Biosens Bioelectron 24: 2798-2803.
-
(2009)
Biosens Bioelectron
, vol.24
, pp. 2798-2803
-
-
Krinke, D.1
Jahnke, H.G.2
Panke, O.3
Robitzki, A.A.4
-
20
-
-
77957888595
-
Real-time monitoring of relaxation and contractility of smooth muscle cells on a novel biohybrid chip
-
Haas S, Jahnke HG, Glass M, Azendorf R, Schmidt S, et al. (2010) Real-time monitoring of relaxation and contractility of smooth muscle cells on a novel biohybrid chip. Lab Chip 10: 2965-2971.
-
(2010)
Lab Chip
, vol.10
, pp. 2965-2971
-
-
Haas, S.1
Jahnke, H.G.2
Glass, M.3
Azendorf, R.4
Schmidt, S.5
-
21
-
-
79960454962
-
A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring
-
Krinke D, Jahnke HG, Mack TG, Hirche A, Striggow F, et al. (2010) A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring. Biosens Bioelectron 26: 162-168.
-
(2010)
Biosens Bioelectron
, vol.26
, pp. 162-168
-
-
Krinke, D.1
Jahnke, H.G.2
Mack, T.G.3
Hirche, A.4
Striggow, F.5
-
22
-
-
84855772725
-
Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures
-
Jahnke HG, Braesigk A, Mack TG, Ponick S, Striggow F, et al. (2012) Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures. Biosens Bioelectron 32: 250-258.
-
(2012)
Biosens Bioelectron
, vol.32
, pp. 250-258
-
-
Jahnke, H.G.1
Braesigk, A.2
Mack, T.G.3
Ponick, S.4
Striggow, F.5
-
23
-
-
33645065611
-
QT PRODACT: comparison of non-clinical studies for drug-induced delay in ventricular repolarization and their role in safety evaluation in humans
-
Omata T, Kasai C, Hashimoto M, Hombo T, Yamamoto K, (2005) QT PRODACT: comparison of non-clinical studies for drug-induced delay in ventricular repolarization and their role in safety evaluation in humans. J Pharmacol Sci 99: 531-541.
-
(2005)
J Pharmacol Sci
, vol.99
, pp. 531-541
-
-
Omata, T.1
Kasai, C.2
Hashimoto, M.3
Hombo, T.4
Yamamoto, K.5
-
24
-
-
44349178015
-
Drug testing on 3D in vitro tissues trapped on a microcavity chip
-
Kloss D, Fischer M, Rothermel A, Simon JC, Robitzki AA, (2008) Drug testing on 3D in vitro tissues trapped on a microcavity chip. Lab Chip 8: 879-884.
-
(2008)
Lab Chip
, vol.8
, pp. 879-884
-
-
Kloss, D.1
Fischer, M.2
Rothermel, A.3
Simon, J.C.4
Robitzki, A.A.5
-
25
-
-
65649128544
-
An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells
-
Jahnke HG, Rothermel A, Sternberger I, Mack TG, Kurz RG, et al. (2009) An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells. Lab Chip 9: 1422-1428.
-
(2009)
Lab Chip
, vol.9
, pp. 1422-1428
-
-
Jahnke, H.G.1
Rothermel, A.2
Sternberger, I.3
Mack, T.G.4
Kurz, R.G.5
-
26
-
-
67049088173
-
A translational approach to detecting drug-induced cardiac injury with cardiac troponins: consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute
-
Berridge BR, Pettit S, Walker DB, Jaffe AS, Schultze AE, et al. (2009) A translational approach to detecting drug-induced cardiac injury with cardiac troponins: consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute. Am Heart J 158: 21-29.
-
(2009)
Am Heart J
, vol.158
, pp. 21-29
-
-
Berridge, B.R.1
Pettit, S.2
Walker, D.B.3
Jaffe, A.S.4
Schultze, A.E.5
-
27
-
-
84862285036
-
Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers
-
Lee P, Klos M, Bollensdorff C, Hou L, Ewart P, et al. (2012) Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers. Circ Res 110: 1556-1563.
-
(2012)
Circ Res
, vol.110
, pp. 1556-1563
-
-
Lee, P.1
Klos, M.2
Bollensdorff, C.3
Hou, L.4
Ewart, P.5
-
28
-
-
84876755488
-
Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture
-
Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, et al. (2013) Ultrastructural maturation of human-induced pluripotent stem cell-derived cardiomyocytes in a long-term culture. Circ J 77: 1307-1314.
-
(2013)
Circ J
, vol.77
, pp. 1307-1314
-
-
Kamakura, T.1
Makiyama, T.2
Sasaki, K.3
Yoshida, Y.4
Wuriyanghai, Y.5
-
29
-
-
84867746044
-
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method
-
Zhang J, Klos M, Wilson GF, Herman AM, Lian X, et al. (2012) Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res 111: 1125-1136.
-
(2012)
Circ Res
, vol.111
, pp. 1125-1136
-
-
Zhang, J.1
Klos, M.2
Wilson, G.F.3
Herman, A.M.4
Lian, X.5
-
30
-
-
0242353365
-
Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures
-
Halbach M, Egert U, Hescheler J, Banach K, (2003) Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures. Cell Physiol Biochem 13: 271-284.
-
(2003)
Cell Physiol Biochem
, vol.13
, pp. 271-284
-
-
Halbach, M.1
Egert, U.2
Hescheler, J.3
Banach, K.4
-
31
-
-
45349084219
-
Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates
-
Ungrin MD, Joshi C, Nica A, Bauwens C, Zandstra PW, (2008) Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates. PLoS One 3: e1565.
-
(2008)
PLoS One
, vol.3
-
-
Ungrin, M.D.1
Joshi, C.2
Nica, A.3
Bauwens, C.4
Zandstra, P.W.5
-
32
-
-
79955583972
-
Derivation of human induced pluripotent stem cells for cardiovascular disease modeling
-
Narsinh K, Narsinh KH, Wu JC, (2011) Derivation of human induced pluripotent stem cells for cardiovascular disease modeling. Circ Res 108: 1146-1156.
-
(2011)
Circ Res
, vol.108
, pp. 1146-1156
-
-
Narsinh, K.1
Narsinh, K.H.2
Wu, J.C.3
-
33
-
-
0028815401
-
Evidence for reduction of norepinephrine uptake sites in the failing human heart
-
Bohm M, La Rosee K, Schwinger RH, Erdmann E, (1995) Evidence for reduction of norepinephrine uptake sites in the failing human heart. J Am Coll Cardiol 25: 146-153.
-
(1995)
J Am Coll Cardiol
, vol.25
, pp. 146-153
-
-
Bohm, M.1
La Rosee, K.2
Schwinger, R.H.3
Erdmann, E.4
-
34
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
-
Redfern WS, Carlsson L, Davis AS, Lynch WG, MacKenzie I, et al. (2003) Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res 58: 32-45.
-
(2003)
Cardiovasc Res
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
-
35
-
-
71449093788
-
Introducing a new entity: chemotherapy-induced arrhythmia
-
Guglin M, Aljayeh M, Saiyad S, Ali R, Curtis AB, (2009) Introducing a new entity: chemotherapy-induced arrhythmia. Europace 11: 1579-1586.
-
(2009)
Europace
, vol.11
, pp. 1579-1586
-
-
Guglin, M.1
Aljayeh, M.2
Saiyad, S.3
Ali, R.4
Curtis, A.B.5
-
36
-
-
84875237101
-
Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity
-
Pointon A, Abi-Gerges N, Cross MJ, Sidaway JE (2013) Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity. Toxicol Sci.
-
(2013)
Toxicol Sci
-
-
Pointon, A.1
Abi-Gerges, N.2
Cross, M.J.3
Sidaway, J.E.4
-
37
-
-
77957373096
-
Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells
-
Andersson H, Steel D, Asp J, Dahlenborg K, Jonsson M, et al. (2010) Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells. J Biotechnol 150: 175-181.
-
(2010)
J Biotechnol
, vol.150
, pp. 175-181
-
-
Andersson, H.1
Steel, D.2
Asp, J.3
Dahlenborg, K.4
Jonsson, M.5
-
38
-
-
79961113909
-
Kinetic targeting of pegylated liposomal doxorubicin: a new approach to reduce toxicity during chemotherapy (CARL-trial)
-
Eckes J, Schmah O, Siebers JW, Groh U, Zschiedrich S, et al. (2011) Kinetic targeting of pegylated liposomal doxorubicin: a new approach to reduce toxicity during chemotherapy (CARL-trial). BMC Cancer 11: 337.
-
(2011)
BMC Cancer
, vol.11
, pp. 337
-
-
Eckes, J.1
Schmah, O.2
Siebers, J.W.3
Groh, U.4
Zschiedrich, S.5
|