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Volumn 28, Issue 4, 2013, Pages 521-526

Ghrelin and cachexia in chronic kidney disease

Author keywords

Cachexia; Chronic kidney disease; Cytokine; Feeding regulatory peptide; Ghrelin

Indexed keywords

ALPHA INTERMEDIN; CASPASE 3; GHRELIN; GHRELIN RECEPTOR; INTERMEDIN; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; PROOPIOMELANOCORTIN; ROSIGLITAZONE; ANTIINFLAMMATORY AGENT; APPETITE STIMULANT; AUTACOID; CYTOKINE;

EID: 84879963081     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-012-2241-6     Document Type: Review
Times cited : (12)

References (50)
  • 1
    • 33747054431 scopus 로고    scopus 로고
    • Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic disease
    • 16932335 10.1038/ncpendmet0221 1:CAS:528:DC%2BD28Xosl2ht78%3D
    • Deboer MD, Marks DL (2006) Therapy insight: Use of melanocortin antagonists in the treatment of cachexia in chronic disease. Nat Clin Pract Endocrinol Metab 2:459-466
    • (2006) Nat Clin Pract Endocrinol Metab , vol.2 , pp. 459-466
    • Deboer, M.D.1    Marks, D.L.2
  • 2
    • 33750970840 scopus 로고    scopus 로고
    • Energy homeostasis and cachexia in chronic kidney disease
    • 16897005 10.1007/s00467-006-0194-3
    • Mak RH, Cheung W (2006) Energy homeostasis and cachexia in chronic kidney disease. Pediatr Nephrol 21:1807-1814
    • (2006) Pediatr Nephrol , vol.21 , pp. 1807-1814
    • Mak, R.H.1    Cheung, W.2
  • 4
    • 34250667431 scopus 로고    scopus 로고
    • Melanocortin interventions in cachexia: How soon from bench to bedside?
    • 17563464 10.1097/MCO.0b013e328108f441 1:CAS:528:DC%2BD2sXotl2lsbY%3D
    • Deboer MD (2007) Melanocortin interventions in cachexia: how soon from bench to bedside? Curr Opin Clin Nutr Metab Care 10:457-462
    • (2007) Curr Opin Clin Nutr Metab Care , vol.10 , pp. 457-462
    • Deboer, M.D.1
  • 6
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • 15070777 10.1073/pnas.0305930101 1:CAS:528:DC%2BD2cXjtFKisb0%3D
    • Sun Y (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 101:4679-4684
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4679-4684
    • Sun, Y.1
  • 8
    • 77952703335 scopus 로고    scopus 로고
    • Ghrelin and growth hormone: Story in reverse
    • 20435917 10.1073/pnas.1002941107 1:CAS:528:DC%2BC3cXmsVOrsL8%3D
    • Nass RM, Gaylinn BD, Rogol AD, Thorner MO (2010) Ghrelin and growth hormone: story in reverse. Proc Natl Acad Sci USA 107:8501-8502
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8501-8502
    • Nass, R.M.1    Gaylinn, B.D.2    Rogol, A.D.3    Thorner, M.O.4
  • 9
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • 10604470 10.1038/45230 1:CAS:528:DC%2BD3cXjs1Ki
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 12
    • 0034731310 scopus 로고    scopus 로고
    • Ghrelin and des-acyl ghrelin: Two major forms of rat ghrelin peptide in gastrointestinal tissue
    • 11162448 10.1006/bbrc.2000.4039 1:CAS:528:DC%2BD3MXivVaksA%3D%3D
    • Hosoda H, Kojima M, Matsuo H, Kangawa K (2000) Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 279:909-913
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 909-913
    • Hosoda, H.1    Kojima, M.2    Matsuo, H.3    Kangawa, K.4
  • 13
    • 10844287775 scopus 로고    scopus 로고
    • Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
    • 15591499 10.1136/gut.2004.038737 1:CAS:528:DC%2BD2MXntFOruw%3D%3D
    • Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shinfuku N, Ueta Y, Meguid MM, Kasuga M (2005) Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 54:18-24
    • (2005) Gut , vol.54 , pp. 18-24
    • Asakawa, A.1    Inui, A.2    Fujimiya, M.3    Sakamaki, R.4    Shinfuku, N.5    Ueta, Y.6    Meguid, M.M.7    Kasuga, M.8
  • 14
    • 22344435662 scopus 로고    scopus 로고
    • Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    • 16012930 10.1053/j.gastro.2005.04.015 1:CAS:528:DC%2BD2MXntVGrsL0%3D
    • Chen CY, Inui A, Asakawa A, Fujino K, Kato I, Chen CC, Ueno N, Fujimiya M (2005) Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 129:8-25
    • (2005) Gastroenterology , vol.129 , pp. 8-25
    • Chen, C.Y.1    Inui, A.2    Asakawa, A.3    Fujino, K.4    Kato, I.5    Chen, C.C.6    Ueno, N.7    Fujimiya, M.8
  • 15
    • 0035430665 scopus 로고    scopus 로고
    • Ghrelin: An orexigenic and somatotrophic signal from the stomach
    • 11483998 10.1038/35086018 1:CAS:528:DC%2BD3MXmtVaqtbo%3D
    • Inui A (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2:551-560
    • (2001) Nat Rev Neurosci , vol.2 , pp. 551-560
    • Inui, A.1
  • 18
    • 79955938111 scopus 로고    scopus 로고
    • Hypothalamic proopiomelanocortin processing and the regulation of energy balance
    • 21208604 10.1016/j.ejphar.2010.10.107 1:CAS:528:DC%2BC3MXmtFGju7w%3D
    • Wardlaw SL (2011) Hypothalamic proopiomelanocortin processing and the regulation of energy balance. Eur J Pharmacol 660:213-219
    • (2011) Eur J Pharmacol , vol.660 , pp. 213-219
    • Wardlaw, S.L.1
  • 19
    • 17844401704 scopus 로고    scopus 로고
    • Anatomy and regulation of the central melanocortin system
    • 15856065 10.1038/nn1455 1:CAS:528:DC%2BD2MXjsFyktbo%3D
    • Cone RD (2005) Anatomy and regulation of the central melanocortin system. Nat Neurosci 8:571-578
    • (2005) Nat Neurosci , vol.8 , pp. 571-578
    • Cone, R.D.1
  • 20
    • 77957267841 scopus 로고    scopus 로고
    • Alterations in appetite-regulating hormones influence protein-energy wasting in pediatric patients with chronic kidney disease
    • 20607302 10.1007/s00467-010-1588-9
    • Büscher AK, Büscher R, Hauffa BP, Hoyer PF (2010) Alterations in appetite-regulating hormones influence protein-energy wasting in pediatric patients with chronic kidney disease. Pediatr Nephrol 25:2295-2301
    • (2010) Pediatr Nephrol , vol.25 , pp. 2295-2301
    • Büscher, A.K.1    Büscher, R.2    Hauffa, B.P.3    Hoyer, P.F.4
  • 21
    • 0029063190 scopus 로고
    • Why are dialysis patients malnourished?
    • 7611257 10.1016/0272-6386(95)90178-7
    • Bergström J (1995) Why are dialysis patients malnourished? Am J Kidney Dis 26:229-241
    • (1995) Am J Kidney Dis , vol.26 , pp. 229-241
    • Bergström, J.1
  • 22
    • 0031911147 scopus 로고    scopus 로고
    • Robert H Herman Memorial Award in Clinical Nutrition Lecture, 1997. Mechanisms causing loss of lean body mass in kidney disease
    • 9497177 1:CAS:528:DyaK1cXhsVequ7w%3D
    • Mitch WE (1998) Robert H Herman Memorial Award in Clinical Nutrition Lecture, 1997. Mechanisms causing loss of lean body mass in kidney disease. Am J Clin Nutr 67:359-366
    • (1998) Am J Clin Nutr , vol.67 , pp. 359-366
    • Mitch, W.E.1
  • 23
    • 0142203432 scopus 로고    scopus 로고
    • Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure
    • 9294834
    • Heimbürger O, Lönnqvist F, Danielsson A, Nordenström J, Stenvinkel P (1997) Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J Am Soc Nephrol 8:1423-1430
    • (1997) J Am Soc Nephrol , vol.8 , pp. 1423-1430
    • Heimbürger, O.1    Lönnqvist, F.2    Danielsson, A.3    Nordenström, J.4    Stenvinkel, P.5
  • 24
    • 0036297423 scopus 로고    scopus 로고
    • Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease
    • 12089386 10.1097/01.ASN.0000019900.87535.43
    • Shinohara K, Shoji T, Emoto M, Tahara H, Koyama H, Ishimura E, Miki T, Tabata T, Nishizawa Y (2002) Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. J Am Soc Nephrol 13:1894-1900
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1894-1900
    • Shinohara, K.1    Shoji, T.2    Emoto, M.3    Tahara, H.4    Koyama, H.5    Ishimura, E.6    Miki, T.7    Tabata, T.8    Nishizawa, Y.9
  • 25
    • 33846185124 scopus 로고    scopus 로고
    • Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients
    • 17063174 10.1038/sj.ki.5001984 1:CAS:528:DC%2BD2sXivFOlsg%3D%3D
    • Siew ED, Pupim LB, Majchrzak KM, Shintani A, Flakoll PJ, Ikizler TA (2007) Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int 71:146-152
    • (2007) Kidney Int , vol.71 , pp. 146-152
    • Siew, E.D.1    Pupim, L.B.2    Majchrzak, K.M.3    Shintani, A.4    Flakoll, P.J.5    Ikizler, T.A.6
  • 26
    • 33646354403 scopus 로고    scopus 로고
    • Chronic kidney disease causes defects in signaling through the insulin receptor substrate/ phosphatidylinositol 3-kinase/ Akt pathway: Implications for muscle atrophy
    • 16611720 10.1681/ASN.2004100842 1:CAS:528:DC%2BD28XkvVKrsbw%3D
    • Bailey JL, Zheng B, Hu Z, Price SR, Mitch WE (2006) Chronic kidney disease causes defects in signaling through the insulin receptor substrate/ phosphatidylinositol 3-kinase/ Akt pathway: implications for muscle atrophy. J Am Soc Nephrol 17:1388-1394
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1388-1394
    • Bailey, J.L.1    Zheng, B.2    Hu, Z.3    Price, S.R.4    Mitch, W.E.5
  • 27
    • 0030593939 scopus 로고    scopus 로고
    • Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway
    • 8948566 10.1056/NEJM199612193352507 1:CAS:528:DyaK2sXjt1OjtA%3D%3D
    • Mitch WE, Goldberg AL (1996) Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med 335:1897-1905
    • (1996) N Engl J Med , vol.335 , pp. 1897-1905
    • Mitch, W.E.1    Goldberg, A.L.2
  • 28
    • 0036679425 scopus 로고    scopus 로고
    • Malnutrition: A frequent misdiagnosis for hemodialysis patients
    • 12189236 1:CAS:528:DC%2BD38XmsVSlurs%3D
    • Mitch WE (2002) Malnutrition: a frequent misdiagnosis for hemodialysis patients. J Clin Invest 110:437-439
    • (2002) J Clin Invest , vol.110 , pp. 437-439
    • Mitch, W.E.1
  • 29
    • 0025790949 scopus 로고
    • Tumor necrosis factor induces skeletal muscle protein breakdown in rats
    • 2035628 1:CAS:528:DyaK3MXktVKksLw%3D
    • Goodman MN (1991) Tumor necrosis factor induces skeletal muscle protein breakdown in rats. Am J Physiol 260:E727-E730
    • (1991) Am J Physiol , vol.260
    • Goodman, M.N.1
  • 30
    • 85047693596 scopus 로고    scopus 로고
    • Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions
    • 14702115 1:CAS:528:DC%2BD2cXjsVGltw%3D%3D
    • Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE (2004) Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113:115-123
    • (2004) J Clin Invest , vol.113 , pp. 115-123
    • Du, J.1    Wang, X.2    Miereles, C.3    Bailey, J.L.4    Debigare, R.5    Zheng, B.6    Price, S.R.7    Mitch, W.E.8
  • 31
    • 2542496898 scopus 로고    scopus 로고
    • Regulation of muscle protein degradation: Coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase
    • 15153564 10.1097/01.ASN.0000127211.86206.E1 1:CAS:528: DC%2BD2cXktVWiurw%3D
    • Lee SW, Dai G, Hu Z, Wang X, Du J, Mitch WE (2004) Regulation of muscle protein degradation: coordinated control of apoptotic and ubiquitin-proteasome systems by phosphatidylinositol 3 kinase. J Am Soc Nephrol 15:1537-1545
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1537-1545
    • Lee, S.W.1    Dai, G.2    Hu, Z.3    Wang, X.4    Du, J.5    Mitch, W.E.6
  • 32
    • 20444497662 scopus 로고    scopus 로고
    • Role of leptin and melanocortin signaling in uremia-associated cachexia
    • 15931394 10.1172/JCI22521 1:CAS:528:DC%2BD2MXkvF2lsrc%3D
    • Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak RH (2005) Role of leptin and melanocortin signaling in uremia-associated cachexia. J Clin Invest 115:1659-1665
    • (2005) J Clin Invest , vol.115 , pp. 1659-1665
    • Cheung, W.1    Yu, P.X.2    Little, B.M.3    Cone, R.D.4    Marks, D.L.5    Mak, R.H.6
  • 35
    • 72949107126 scopus 로고    scopus 로고
    • Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease
    • 19890275 10.1038/ki.2009.411 1:CAS:528:DC%2BD1MXhsFGms73F
    • Barazzoni R, Zhu X, Deboer M, Datta R, Culler MD, Zanetti M, Guarnieri G, Marks DL (2010) Combined effects of ghrelin and higher food intake enhance skeletal muscle mitochondrial oxidative capacity and AKT phosphorylation in rats with chronic kidney disease. Kidney Int 77:23-28
    • (2010) Kidney Int , vol.77 , pp. 23-28
    • Barazzoni, R.1    Zhu, X.2    Deboer, M.3    Datta, R.4    Culler, M.D.5    Zanetti, M.6    Guarnieri, G.7    Marks, D.L.8
  • 37
    • 38849187108 scopus 로고    scopus 로고
    • Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients
    • 17854954 10.1016/j.clnu.2007.06.013 1:CAS:528:DC%2BD1cXhslOltrg%3D
    • Barazzoni R, Zanetti M, Stulle M, Mucci MP, Pirulli A, Dore F, Panzetta G, Vasile A, Biolo G, Guarnieri G (2008) Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients. Clin Nutr 27:142-149
    • (2008) Clin Nutr , vol.27 , pp. 142-149
    • Barazzoni, R.1    Zanetti, M.2    Stulle, M.3    Mucci, M.P.4    Pirulli, A.5    Dore, F.6    Panzetta, G.7    Vasile, A.8    Biolo, G.9    Guarnieri, G.10
  • 38
    • 79952689406 scopus 로고    scopus 로고
    • Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients
    • 21178976 10.1038/ki.2010.487 1:CAS:528:DC%2BC3MXjtFGjtbs%3D
    • Carrero JJ, Nakashima A, Qureshi AR, Lindholm B, Heimburger O, Barany P, Stenvinkel P (2011) Protein-energy wasting modifies the association of ghrelin with inflammation, leptin, and mortality in hemodialysis patients. Kidney Int 79:749-756
    • (2011) Kidney Int , vol.79 , pp. 749-756
    • Carrero, J.J.1    Nakashima, A.2    Qureshi, A.R.3    Lindholm, B.4    Heimburger, O.5    Barany, P.6    Stenvinkel, P.7
  • 40
    • 78449281408 scopus 로고    scopus 로고
    • Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease
    • 20734087 10.1007/s00467-010-1628-5
    • Naufel MF, Bordon M, de Aquino TM, Ribeiro EB, de Abreu Carvalhaes JT (2010) Plasma levels of acylated and total ghrelin in pediatric patients with chronic kidney disease. Pediatr Nephrol 25:2477-2482
    • (2010) Pediatr Nephrol , vol.25 , pp. 2477-2482
    • Naufel, M.F.1    Bordon, M.2    De Aquino, T.M.3    Ribeiro, E.B.4    De Abreu Carvalhaes, J.T.5
  • 41
    • 58449095201 scopus 로고    scopus 로고
    • Ghrelin and other appetite-regulating hormones in paediatric patients with chronic renal failure during dialysis and following kidney transplantation
    • 18809976 10.1093/ndt/gfn529
    • Arbeiter AK, Büscher R, Petersenn S, Hauffa BP, Mann K, Hoyer PF (2008) Ghrelin and other appetite-regulating hormones in paediatric patients with chronic renal failure during dialysis and following kidney transplantation. Nephrol Dial Transplant 24:643-646
    • (2008) Nephrol Dial Transplant , vol.24 , pp. 643-646
    • Arbeiter, A.K.1    Büscher, R.2    Petersenn, S.3    Hauffa, B.P.4    Mann, K.5    Hoyer, P.F.6
  • 44
    • 1042268898 scopus 로고    scopus 로고
    • Associations between plasma ghrelin levels and body composition in end-stage renal disease: A longitudinal study
    • 14736968 10.1093/ndt/gfg559 1:CAS:528:DC%2BD2cXms1akuw%3D%3D
    • Rodriguez Ayala E, Pecoits-Filho R, Heimbürger O, Lindholm B, Nordfors L, Stenvinkel P (2004) Associations between plasma ghrelin levels and body composition in end-stage renal disease: a longitudinal study. Nephrol Dial Transplant 19:421-426
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 421-426
    • Rodriguez Ayala, E.1    Pecoits-Filho, R.2    Heimbürger, O.3    Lindholm, B.4    Nordfors, L.5    Stenvinkel, P.6
  • 45
    • 32844466580 scopus 로고    scopus 로고
    • Acute plasma ghrelin and leptin responses to oral feeding or intraperitoneal hypertonic glucose-based dialysate in patients with chronic renal failure
    • 16316365 10.1111/j.1523-1755.2005.00761.x
    • Pérez-Fontán M, Cordido F, Rodríguez-Carmona A, García-Naveiro R, Isidro ML, Villaverde P, García-Buela J (2005) Acute plasma ghrelin and leptin responses to oral feeding or intraperitoneal hypertonic glucose-based dialysate in patients with chronic renal failure. Kidney Int 68:2877-2885
    • (2005) Kidney Int , vol.68 , pp. 2877-2885
    • Pérez-Fontán, M.1    Cordido, F.2    Rodríguez-Carmona, A.3    García-Naveiro, R.4    Isidro, M.L.5    Villaverde, P.6    García-Buela, J.7
  • 46
    • 79952650364 scopus 로고    scopus 로고
    • Is ghrelin a biomarker for mortality in end-stage renal disease?
    • 21403653 10.1038/ki.2010.520 1:CAS:528:DC%2BC3MXjtFGjtLc%3D
    • Mak RH, Cheung WW (2011) Is ghrelin a biomarker for mortality in end-stage renal disease? Kidney Int 79:697-699
    • (2011) Kidney Int , vol.79 , pp. 697-699
    • Mak, R.H.1    Cheung, W.W.2
  • 47
    • 49749111114 scopus 로고    scopus 로고
    • Emergence of ghrelin as a treatment for cachexia syndromes
    • 18725076 10.1016/j.nut.2008.06.013 1:CAS:528:DC%2BD1cXhtVent73J
    • DeBoer MD (2008) Emergence of ghrelin as a treatment for cachexia syndromes. Nutrition 24:806-814
    • (2008) Nutrition , vol.24 , pp. 806-814
    • Deboer, M.D.1
  • 49
    • 80755132092 scopus 로고    scopus 로고
    • Ghrelin receptors are expressed by distal tubules of the mouse kidney
    • 21956643 10.1007/s00441-011-1240-4 1:CAS:528:DC%2BC3MXhsVSktrvI
    • Venables G, Hunne B, Bron R, Cho HJ, Brock JA, Furness JB (2011) Ghrelin receptors are expressed by distal tubules of the mouse kidney. Cell Tissue Res 346:135-139
    • (2011) Cell Tissue Res , vol.346 , pp. 135-139
    • Venables, G.1    Hunne, B.2    Bron, R.3    Cho, H.J.4    Brock, J.A.5    Furness, J.B.6
  • 50
    • 79953182981 scopus 로고    scopus 로고
    • Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats
    • 21220707 10.1161/HYPERTENSIONAHA.110.166413 1:CAS:528: DC%2BC3MXitVOgt70%3D
    • Kemp BA, Howell NL, Gray JT, Keller SR, Nass RM, Padia SH (2011) Intrarenal ghrelin infusion stimulates distal nephron-dependent sodium reabsorption in normal rats. Hypertension 57:633-639
    • (2011) Hypertension , vol.57 , pp. 633-639
    • Kemp, B.A.1    Howell, N.L.2    Gray, J.T.3    Keller, S.R.4    Nass, R.M.5    Padia, S.H.6


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