Rosuvastatin prevents pressure overload-induced myocardial hypertrophy via inactivation of the Akt, ERK1/2 and GATA4 signaling pathways in rats

Molecular Medicine Reports

Volumn 8, Issue 2, 2013, Pages 385-392

  Xu, Xue ^a   Zhang, Lei ^a   Liang, Jiangjiu ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Akt; Extracellular signal regulated kinase 1 2; GATA binding protein 4; Myocardial hypertrophy; Pressure overload; Rosuvastatin

Indexed keywords

ATRIAL NATRIURETIC FACTOR; EOSIN; HEMATOXYLIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; MYOSIN HEAVY CHAIN BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE B; ROSUVASTATIN; TRANSCRIPTION FACTOR GATA 4;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA OCCLUSION; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE OVERLOAD; HEART VENTRICLE HYPERTROPHY; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; STAINING; WESTERN BLOTTING;

ANIMALS; CARDIOMEGALY; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; FLUOROBENZENES; GATA4 TRANSCRIPTION FACTOR; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; RATS; SIGNAL TRANSDUCTION; SULFONAMIDES;

RATTUS; RATTUS NORVEGICUS; RICE STRIPE VIRUS;

EID: 84879960701     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1548     Document Type: Article

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