Rosuvastatin inhibits norepinephrine-induced cardiac hypertrophy via suppression of Gh

European Journal of Pharmacology

Volumn 627, Issue 1-3, 2010, Pages 56-62

  Choi, Eui Young ^a   Chang, Woochul ^b   Lim, Soyeon ^c   Song, Byeong Wook ^d   Cha, Min Ji ^d   Kim, Hye Jung ^d   Choi, Eunju ^d   Jang, Yangsoo ^a,d   Chung, Namsik ^a,d   Hwang, Ki Chul ^d  

^a Yonsei University College of Medicine   (South Korea)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^d Yonsei University College of Medicine   (South Korea)

Author keywords

Cardiomyocytes; G proteins; Hypertrophy; Rosuvastatin

Indexed keywords

CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MYOSIN LIGHT CHAIN 2; NORADRENALIN; PROTEIN KINASE C; ROSUVASTATIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; IMMUNOBLOTTING; NEWBORN; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; CALCIUM; CARDIAC MYOSINS; CARDIOMEGALY; CELL MEMBRANE; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLUOROBENZENES; GTP-BINDING PROTEINS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTRACELLULAR SPACE; MYOCYTES, CARDIAC; MYOSIN LIGHT CHAINS; NOREPINEPHRINE; PROTEIN TRANSPORT; PROTO-ONCOGENES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SULFONAMIDES; TRANSFECTION;

EID: 73449095194     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.10.050     Document Type: Article

References (28)

1. Brown J.H., Del Re D.P., and Sussman M.A. The Rac and Rho hall of fame: a decade of hypertrophic signaling hits. Circ. Res. 98 (2006) 730-742
2. Clerk A., Pham F.H., Fuller S.J., Sahai E., Aktories K., Marais R., Marshall C., and Sugden P.H. Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein rac1. Mol. Cell. Biol. 21 (2001) 1173-1184
3. DeBosch B., Treskov I., Lupu T.S., Weinheimer C., Kovacs A., Courtois M., and Muslin A.J. Akt1 is required for physiological cardiac growth. Circulation 113 (2006) 2097-2104
4. Go A.S., Lee W.Y., Yang J., Lo J.C., and Gurwitz J.H. Statin therapy and risks for death and hospitalization in chronic heart failure. JAMA 296 (2006) 2105-2111
5. 1-Adrenergic receptor subtypes: molecular structure, function, and signaling. Circ. Res. 78 (1996) 737-739
6. Higuchi Y., Otsu K., Nishida K., Hirotani S., Nakayama H., Yamaguchi O., Hikoso S., Kashiwase K., Takeda T., Watanabe T., Mano T., Matsumura Y., Ueno H., and Hori M. The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and NF-kappa B. J. Biol. Chem. 278 (2003) 20770-20777
7. Hirotani S., Otsu K., Nishida K., Higuchi Y., Morita T., Nakayama H., Yamaguchi O., Mano T., Matsumura Y., Ueno H., Tada M., and Hori M. Involvement of nuclear factor-kappa B and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy. Circulation 105 (2002) 509-515
8. Huckle W., Dy R., and Earp H. Calcium-dependent increase in tyrosine kinase activity stimulated by angiotensin II. Proc. Natl. Acad. Sci. USA 89 (1992) 8837-8841
9. Hwang K.C., Gray C.D., Sweet W.E., Moravec C.S., and Im M.J. Alpha1-adrenergic receptor coupling with Gh in the failing human heart. Circulation 94 (1996) 718-726
10. Iismaa T., Biden T.J., and Shine J. G-Protein-Coupled Receptors (1994), CRC Press, New York
11. Kodama H., Fukuda K., Takahashi T., Sano M., Kato T., Tahara S., Hakuno D., Sato T., Manabe T., Konishi F., and Ogawa S. Role of EGF receptor and Pyk2 in endothelin-1-induced ERK activation in rat cardiomyocytes. J. Mol. Cell. Cardiol. 34 (2002) 139-150
12. Lee K.H., Lee N., Lim S., Jung H., Ko Y.G., Park H.Y., Jang Y., Lee H., and Hwang K.C. Calreticulin inhibits the MEK1, 2-ERK1, 2 pathway in α1-adrenergic receptor/Gh-stimulated hypertrophy of neonatal rat cardiomyocytes. J. Steroid Biochem. Mol. Biol. 854 (2003) 101-107
13. 2+-induced regulation of ion channel and MAP kinase functions. Nature 376 (1995) 737-745
14. Maack C., Karte T., Kilter H., Schafers H.J., Nickenig G., Bohm M., and Laufs U. Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment. Circulation 108 (2003) 1567-1574
15. Melino G., and Piacentini M. 'Tissue' transglutaminase in cell death: a downstream or a multifunctional upstream effector?. FEBS. Lett. 430(1-2) (1998) 59-63
16. Mhaouty-Kodja S. Ghalpha/tissue transglutaminase 2: an emerging G protein in signal transduction. Biol. Cell 96 (2004) 363-367
17. Molkentin J.D., and Dorn II G.W. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu. Rev. Physiol. 63 (2001) 391-426
18. Mühlhäuser U., Zolk O., Rau T., Münzel F., Wieland T., and Eschenhagen T. Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits. FASEB J. 20 (2006) 785-787
19. Murasawa S., Matsubara H., Mori Y., Masaki H., Tsutsumi Y., Shibasaki Y., Kitabayashi I., Tanaka Y., Fujiyama S., Koyama Y., Fujiyama A., Iba S., and Iwasaka T. Angiotensin II initiates tyrosine kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase. J. Biol. Chem. 275 (2000) 26856-26863
20. Piascik M.T., and Perez D.M. Alpha1-adrenergic receptors: new insights and directions. J. Pharmacol. Exp. Ther. 298 (2001) 403-410
21. Pracyk J.B., Tanaka K., Hegland D.D., Kim K.S., Sethi R., Rovira I.I., Blazina D.R., Lee L., Bruder J.T., Kovesdi I., Goldshmidt-Clermont P.J., Irani K., and Finkel T. A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. J. Clin. Invest. 102 (1998) 929-937
22. Rikitake Y., and Liao J.K. Rho GTPases, statins, and nitric oxide. Circ. Res. 97 (2005) 1232-1235
23. Sussman M.A., Welch S., Walker A., Klevitsky R., Hewett T.E., Price R.L., Schaefer E., and Yager K. Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. J. Clin. Invest. 105 (2000) 875-886
24. Takemoto M., Node K., Nakagami H., Liao Y., Grimm M., Takemoto Y., Kitakaze M., and Liao J.K. Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy. J. Clin. Invest. 108 (2001) 1429-1437
25. Tardiff J.C. Cardiac hypertrophy: stressing out the heart. J. Clin. Invest. 116 (2006) 1467-1470
26. Wu L., Zhao L., Zheng Q., Shang F., Wang X., Wang L., and Lang B. Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes. Mol. Cell. Biochem. 284 (2006) 65-71
27. Yu H., Li X., Marchetto G.S., Dy R., Hunter D., Calvo B., Dawson T.L., Wilm M., Anderegg R.J., Graves L.M., and Earp H.S. Activation of a novel calcium-dependent protein-tyrosine kinase. J. Biol. Chem. 271 (1996) 29993-29998
28. Zacà V., Rastogi S., Imai M., Wang M., Sharov V.G., Jiang A., Goldstein S., and Sabbah H.N. Chronic monotherapy with rosuvastatin prevents progressive left ventricular dysfunction and remodeling in dogs with heart failure. J. Am. Coll. Cardiol. 50 (2007) 551-557