From ethnopharmacology to clinical study of Orthosiphon stamineus Benth

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 5, Issue 3, 2013, Pages 66-73

  Adnyana, Ketut ^a   Setiawan, Finna ^a   Insanu, Muhamad ^a  

^a BANDUNG INSTITUTE OF TECHNOLOGY   (Indonesia)

Author keywords

Antihypertensive; Java tea; Kumis kucing; Methylripariochromene A; Sinensetin

Indexed keywords

2 O DEACETYLORTHOSIPHONONE A; AMLODIPINE; CARBOXYLIC ACID; DITERPENE; ESSENTIAL OIL; FLAVONOID; METHYLPARIOCHROMENE A; NORSTAMINOLACTONE A; ORTHOSIPHOL A; ORTHOSIPHON STAMINEUS EXTRACT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; ROSMARINIC ACID; SAPONIN; TERPENE; TRITERPENE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CHRONIC TOXICITY; CYTOTOXICITY; DIURETIC ACTIVITY; ETHNOPHARMACOLOGY; HEADACHE; HEART CONTRACTION; HUMAN; HYPERTENSION; LIVER NECROSIS; LIVER PROTECTION; MINIMUM INHIBITORY CONCENTRATION; NAUSEA; NEPHROLITHIASIS; NONHUMAN; OBESITY; ORTHOSIPHON STAMINEUS; PAW EDEMA; PHASE 2 CLINICAL TRIAL (TOPIC); PHYTOCHEMISTRY; PLANT LEAF; REVIEW; STREPTOCOCCUS MUTANS; STRUCTURE ACTIVITY RELATION; TINCTURE; TOXICOLOGY; ULTRASOUND; UNSTABLE ANGINA PECTORIS;

EID: 84879956689     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Kardono L, Artanti N, Dewiyanti I, Basuki T, Padmawinata K. Selected Indonesian medicinal plants. Monographs and descriptions. PT Gramedia Widyasarana; 2003. p. 15.
2. Pramono S. Jamu in Indonesia daily life and industry. Institute of Natural Medicine University of Toyama; 2007. p. 26.
3. Anonymous. Burmese indigenous medicinal plants: 1. plants with reputed hypoglicemic action. Burma medical research institute, 1967.
4. Arisandi Y, Andriani Y. Khasiat tanaman obat. Penerbit pustaka buku murah; 2006. p. 196-98.
5. Anonymous. Medicinal herb index in Indonesia. Eisai Indonesia; 1995. p. 263.
6. Isnandar H. Kumpulan 1001 ramuan obat tradisioinal Indonesia. PJ Dayang sumbi; 2005. p. 109-12.
7. Hossain MA, Ismail Z, Rahman A, Kang SC. Chemical composition and anti-fungal properties of the essential oils and crude extracts of Orthosiphon stamineus Benth, Industrial Crops and Products 2008;27(3):328-34.
8. Sumaryono W, Proksch P, Wray V, Witte L, Hartmann T. Qualitative and quantitative analysis of the phenolic constituents from Orthosiphon aristatus, Planta Med 1991;57(02):176-80.
9. Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota S. Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity, Chem Pharm Bull 2003;51(3):268-75.
10. Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota S. Nitric oxide inhibitory isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia, J Nat Prod 2003;66(2):255-58.
11. Akowuah GA, Zhari I, Norhayati I, Sadikun A, Khamsah SM. Sinensetin, eupatorin, 3'-hydroxy-5, 6, 7, 4'-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia, Food Chem 2004;87(4):559-66.
12. Awale S, Tezuka Y, Banskota AH, Adnyana IK, Kadota S. Inhibition of NO production by highly-oxygenated diterpenes of Orthosiphon stamineus and their structure-activity relationship, Biol Pharm Bull 2003;26(4):468-73.
13. Tezuka Y, Stampoulis P, Banskota AH, Awale S, Tran KQ, Saiki I, et al. Constituents of the Vietnamese medicinal plant Orthosiphon stamineus, Chem Pharm Bul 2000;48(11):1711-19.
14. Yuliana N, Khatib A, Regina AM, Ijzerman AP, zakaria FR, Choi YH, et al. Adenosin A1 receptor binding activity of methoxy flavonoids from Orthosiphon stamineus, Planta Med 2009;75:132-36.
15. Lyckander I, Maltreud K. Liphophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lypooxygenase, Prostag Leukotr Ess 1996;54:239-46.
16. Takeda Y, Matsumoto T, Terao H, Shingu T, Futatsuishi Y, Nohara T, et al. Orthosiphol D and E, minor diterpenes from Orthosiphon stamineus, Phytochemistry 1993;33(2):411-15.
17. Nguyen MTT, Awale S, Tezuka Y, Chien-Hsiung C, Kadota S. Staminane-and isopimarane-type diterpenes from Orthosiphon stamineus of Taiwan and their nitric oxide inhibitory activity, J Nat Prod 2004;67(4):654-58.
18. Sundarammal S, Thirugnanasampandan, Selvi MT. Chemical composition analysis and antioxidant activity evaluation of essential oil from Orthosiphon thymiflorus (Roth.) Sleesen, Asian Pac J Trop Biomed 2012:S112-15.
19. Hossain MA, Ismail Z. New lupene-type triterpene from the leaves of Orthosiphon stamineus, Ind J Chem 2005;44(B):436-37.
20. Matsubara T, Bohgaki T, Watarai M, Suzuki H, Ohashi K, Shibuya H. Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an Indonesian traditional medicinal plant, Biol Pharm Bull 1999;22(10):1083-88.
21. Olah N-K, Radu L, MogoÅŸan C, Hanganu D, Gocan S. Phytochemical and pharmacological studies on Orthosiphon stamineus Benth. (Lamiaceae) hydroalcoholic extracts, J Pharmaceut Biomed 2003;33(1):117-23.
22. Ohashi K, Bohgaki T, Matsubara T, Shibuya H. Indonesian medicinal plants XXIII. Chemical structured of two new migrated pimarane-type Diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the Leaves of Orthosiphon aristatus (Lamiaceae), Chem Pharm Bull 2000;48(3):433-35.
23. Awale S, Tezuka Y, Kobayashi M, Ueda J-y, Kadota S. Neoorthosiphonone A; a nitric oxide (NO) inhibitory diterpene with new carbon skeleton from Orthosiphon stamineus, Tetrahedron Lett 2004;45(7):1359-62.
24. Awale S, Tezuka Y, Banskota AH, Shimoji S, Taira K, Kadota S. Norstaminane-and isopimarane-type diterpenes of Orthosiphon stamineus from Okinawa, Tetrahedron 2002;58(27):5503-12.
25. Awale S, Tezuka Y, Banskota AH, Kadota S. Siphonols A-E: Novel nitric oxide inhibitors from Orthosiphon stamineus of Indonesia, Bioorg Med Chem Lett 2003;13(1):31-35.
26. Masuda T, Masuda K, Shiragami S, Jitoe A, Nakatani N. Orthosiphol A and B, novel diterpenoid inhibitors of TPA (12-O-tetradecanoylphorbol-13-acetate)-induced inflammation, from Orthosiphon stamineus, Tetrahedron 1992;48(33):6787-92.
27. Stampoulis P, Tezuka Y, Banskota AH, Kim Qui T, Saiki I, Kadola S. Staminol A, a novel diterpene from Orthosiphon stamineus, Tetrahedron Lett 1999;40(22):4239-42.
28. Awale S, Tezuka Y, Banskota AH, Kouda K, Tun KM, Kadota S. Four highly oxygenated isopimarane-type diterpenes of Orthosiphon stamineus, Planta Med 2002;68(03):286-88.
29. Shibuya H, Bohgaki T, Matsubara T, Watarai M, Ohashi K, Kitagawa I. Indonesian medicinal plants XXII. Chemical structures of two new isopimarane-type diterpenes, orthosiphonones A and B, and a new benzochromene, orthochromene A from the leaves of Orthosiphon aristatus (Lamiaceae), Chem Pharm Bull 1999;47(5):695-98.
30. Awale S, Tezuka Y, Shimoji S, Taira K, Kadota S. Secoorthosiphols A-C: three highly oxygenated secoisopimarane-type diterpenes from Orthosiphon stamineus, Tetrahedron Lett 2002;43(8):1473-75.
31. Hussein AA, Meyer JJM, Jimeno ML, RodrÃguez B. Bioactive diterpenes from Orthosiphon labiatus and Salvia africana-lutea, J Nat Prod 2007;70(2):293-95.
32. Akowuah GA, Zhari I, Sadikun A, Norhayati I. HPTLC densitometric analysis of Orthosiphon stamineus leaf extracts and inhibitory effect on xanthine oxidase activity, Pharm Biol 2006;44(1):65-70.
33. Akowuah GA, Ismail Z, Norhayati I, Sadikun A. The effects of different extraction solvents of varying polarities on polyphenols of Orthosiphon stamineus and evaluation of the free radical-scavenging activity, Food Chem 2005;93(2):311-17.
34. Akowuah GA, Zhari I, Norhayati I, Sadikun A. Radical scavenging activity of methanol leaf extracts of Orthosiphon stamineus, Pharm Biol 2005;42(8):629-35.
35. Awale S, Tezuka Y, Banskota AH, Kouda K, Tun KM, Kadota S. Five novel highly oxygenated diterpenes of Orthosiphon stamineus from Myanmar, J Nat Prod 2001;64(5):592-96.
36. Beaux D, Fleurentin J, Mortier F. Effect of extracts of Orthosiphon stamineus Benth., Phytother Res 1999;13(3):222-25.
37. Englert J, Harnischfeger G. Diuretic action of aqueous Orthosiphon extract in rats, Planta Med 1992;58(03):237-38.
38. Kannappan N, Madhukar A, Marymmal, Sindhura P, Mannavalan R. Evaluation of nephroprotective activity of Orthosiphon stamineus Benth extract using rat model, Int J Pharm Tech Res Service 2010;2(1):209-15.
39. Sriplang K, Adisakwattana S, Rungsipipat A, Yibchok-anun S. Effects of Orthosiphon stamineus aqueous extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats, J Ethnopharmacol 2007;109(3):510-14.
40. Mohamed E, Mohamed A, Asmawi M, Sadikun A, Ebrika O, Yam M. Antihyperglicemic effect of Orthosiphon stamineus Benth leaves extracts and its bioassay guided fractions, Molecules 2011;16(3787-3801).
41. Ohashi K, Bohgaki T, Shibuya H. Antihypertensive substance in the leaves of kumis kucing (Orthosiphon aristatus) in Java Island, J Pharm Soc Jpn 2000;120(5):474-82.
42. Kiryutina. Effect of Orthosiphon stamineus Benth on the cardiovascular system, US Joint Publication Research Service 1960:1-3.
43. Chen C-P, Lin C-C, Tsuneo N. Screening of Taiwanese crude drugs for antibacterial activity against Streptococcus mutans, J Ethnopharmacol 1989;27(3):285-95.
44. Son J-Y, Park S-Y, Kim J-Y, Won K-C, Kim Y-D, Choi Y-J, et al. Orthosiphon stamineus reduces appetite and visceral fat in rats, J Korean Soc Appl Bi 2011;54(2):200-05.
45. Yam MF, Basir R, Asmawi M, Ismail Z. Antioxidant and hepatoprotective effects of Orthosiphon stamineus Benth. standardized extract, Am J Chin Med 2007;35(1):115-26.
46. Maheswari K, Marymmal R, Venkatanarayan R. Hepatoprotective activity of Orthosiphon stamineus on liver damages caused by paracetamol in rats, Jordan J Biol Sci 2008;1(3):105-08.
47. Faizul F, Aminudin N, Kadir H, Tayyab S. Bilirubin lowering potential of Orthosiphon stamineus in temporarily jaundiced adult rats, Afr J Pharm Pharmacol 2009;3(7):359-61.
48. Leon P, Tillan H, Hernandez R, Chains F, Calzada A. Efeco diuretico y toxicidad aguda del Orthosiphon aristatus Blumme, Cuban Rev Plant Med 1996;1(3):26-30.
49. Mohamed EAH, Lim CP, Ebrika OS, Asmawi MZ, Sadikun A, Yam MF. Toxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineus, J Ethnopharmacol 2011;133(2):358-63.
50. Sittisomwong N, Attawasih A, Chuntapet P. Chronic toxicity test of Orthosiphon aristatus, Bull Dept Med Sci 1999;41(1):41-54.
51. Supari F, Suhendra B, Sani A. Clinical trial of Orthosiphon stamineus. 2001.
52. Premgamone A, Sriboonlue P, Disataporjaroen W, Maskasem S, Sinsupan N. A long term study on efficacy of a herbal plant Orthosiphon grandiflorus and sodium potassium citrate in renal calculi treatment, SE Asian J Trop Med 2001;32(3):654-60.