Evaluation of nephroprotective activity of Orthosiphon stamineus Benth extract using rat model

International Journal of PharmTech Research

Volumn 2, Issue 1, 2010, Pages 209-215

  Kannappan, N ^a   Madhukar, A ^a   Mariymmal, ^a   Sindhura, P Uma ^a   Mannavalan, R ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Gentamycin; Nephrotoxicity activity; Orthosiphon stamineus

Indexed keywords

CREATININE; FLAVONOID; GENTAMICIN; METHANOL; ORTHOSIPHON STAMINEUS EXTRACT; PLANT EXTRACT; POTASSIUM; SAPONIN; SODIUM; TANNIN DERIVATIVE; TERPENOID; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; HISTOPATHOLOGY; KIDNEY INJURY; NEPHROTOXICITY; NONHUMAN; ORTHOSIPHON; PROTEIN URINE LEVEL; RAT; RENAL PROTECTION; SODIUM EXCRETION; UREA BLOOD LEVEL;

EID: 77953399174     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Doan, D. D, Nguyen, Doan, H. K. Studies on the individual and combined diuretic effects of four Vietnamese traditional herbal remedies. J. Ethnopharmacol. 1992, 36(3):225-231.
2. Mariam, A., H. Z. Asmawi, et al., Hypoglycemic activity of the aqueous extract of Orthosiphon stamineus. Fitoterpia 1996, 67(5):465-468.
3. Ohashi, K., Bohagari, J. Matsubara, T, Shibuya, H. Indonesian medical plants XXIII. Chemical structures of two new migrated pimarane - type diterpenes neoortho siphols A and B and Suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon stamineus. Bull. 2000, 48(3):433-435.
4. Ohashi, K., Bohagari, J. Matsubara, T, Shibuya, H. Antihypertensive substance in the leaves of Kumis Kuching (Orthosiphon aristatus) in java island. Yakugaku zasshi, 2000, 120(5):478-482.
5. Nirnoy, M., Muangman, V. Effect of folio Orthosiphon on urinary stone promoters and inhibitors. J. Med. Assoc. Thai. 1991, 74(6):318-321.
6. Englert, J., Harnischfeger, G. Diuretic action of Orthosiphon stamineus extract in rats. Planta Med June 1992, 58(3):237-238.
7. A. I. Bartanov, E. A. Bartanov. Nephroprotective effect of nephrophyte in drug nephropathy induced by urographin. Euromedica hannoeve 2005, 40-41.
8. Akowuah, A. G., Zhari, I., Norhayati, I., Sadikuma. Radical scavenging activity of methanolic extract of Orthosiphon stamineus. Pharm. Biology 2005, 42(8):629-635.
9. Chencplincnamba, TR. Screening of Taiwanese crude drugs for antibacterial activity against streptococcus mutans. J. Ethnopharmacol, 1989, 27(3):285-295.
10. Devasagayam, TPA, Tilak, J. C, Bollork. Review; Free radical and antioxidants in human health. Curr stat fut prosp JAPI 2004, 52, 794-804.
11. Farruch, A., Iqbal ahamadzafer mehmood. Antioxidant and free radical scavenging properties of twelve traditionally used Indian medical plants. Turk. J. Boil. 2006, 30, 177-183.
12. Golamreza karimi, Mohammed ramezani. Cisplastin nephrotoxicity and protection by milk thistle extracts in rats. Ecam advance access. July 2005, 26, 1-4.
13. Lee, S. E., Hwang, H. J., Hajs. Screening of medical plant extracts for antioxidant activity. Life Sci. 2003, 73, 167-179.
14. Lyckander, I. M., Malterud, K. E. Lipophilic flavonoids from Orthosiphon stamineus prevent oxidative inactivation of 15-lipoxyzanase. Prostaglandins leukol Essent. Fatty acids. 1996, 54(4):239-246.
15. Masuda, T. k., Masuda. Orthosiphol A and B. Novel diterpenoid inhibitors of tpa induced inflammation from Orthosiphon stamineus. Tetrahedron letters. 1992, 33(8):6787-6792.
16. Neugarten, J., Aynedjian, H. S., Bank, N. The role of tubular obstruction in acute renal failure due to gentamicin. Kidney Int. 1983, 24(3):330-335.
17. OECD guidelines for the testing of chemical test No. 423. Acute oral toxicity - Acute toxic class method. 1996.
18. Vijayakumar, K., M. V. R. Naidu, Anwar. Probucol protects against gentamicin induced nephrotoxicity in rats. Ind. J. Pharmcol. Res. 2000, 32, 108-113.
19. Walker, P. O., Shah, S.V. Gentamicin enhances production of hydrogen peroxide by renal cortical mitochondria. J. Physiol. 1987, 253, 495-499.
20. Yokazawa, T., Chen, C. P., Dong, E., Tanaka, T., Nonaka, G. I and Nishioka, I. Study on the inhibitory effect of tannins and flavonoids against the 1, 1-diphenyl-2-picrylhydrazyl radical. Biochemical pharmacology. 1998, 56, 213-222.