No benefit adding eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study

Pharmacopsychiatry

Volumn 46, Issue 5, 2013, Pages 181-190

  Schaffler, K ^a   Wolf, O T ^b   Burkart, M ^c  

^a HPR Dr Schaffler GmbH   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

Author keywords

adaptogens; asthenia; concentration; Eleutherococcus; fatigue; RCT; Siberian ginseng; stress

Indexed keywords

ELEUTHEROCOCCUS SENTICOSUS EXTRACT; HYDROCORTISONE;

ADULT; ALERTNESS; ARTICLE; CHRONIC STRESS; COGNITION; CONTROLLED STUDY; DYSTHYMIA; ELEUTHEROCOCCUS SENTICOSUS; EXHAUSTION; FATIGUE; FEMALE; HUMAN; JOB STRESS; MALE; MENTAL CONCENTRATION; MOOD; MULTICENTER STUDY; PHASE 4 CLINICAL TRIAL; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; SLEEP; STRESS; STRESS MANAGEMENT; WEAKNESS; WORK CAPACITY; WORK DISABILITY;

ADULT; AFFECT; ASTHENIA; COMBINED MODALITY THERAPY; ELEUTHEROCOCCUS; FEMALE; GALVANIC SKIN RESPONSE; HEART RATE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; PATIENT SATISFACTION; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PSYCHOMOTOR PERFORMANCE; PSYCHOTHERAPY; QUALITY OF LIFE; SALIVA; STRESS, PSYCHOLOGICAL; WORK CAPACITY EVALUATION;

EID: 84879936123     PISSN: 01763679     EISSN: 14390795     Source Type: Journal    
DOI: 10.1055/s-0033-1347178     Document Type: Article

References (42)

1. Murta S. G., Sanderson K., Oldenburg B. Process evaluation in occupational stress management programs: a systematic review. Am J Health Promot: 2007; 21 248 254
2. Chiesa A., Seretti A. Mindfulness-based stress reduction for stress management in healthy people: a review and meta-analysis. J Altern Complement Med: 2009; 15 593 600
3. Li A. W., Goldsmith C. A. The effects of yoga on anxiety and stress. Altern Med Rev: 2012; 17 21 35
4. Czabała C., Charzyńska K., Mroziak B. Psychosocial interventions in workplace mental health promotion: an overview. Health Promot Int: 2011; 26 01 i70 i84
5. Ratanasiripong P., Ratanasiripong N., Kathalae D. Biofeedback intervention for stress and anxiety among nursing students: a randomized controlled trial. ISRN Nurs 2012; 2012: 827972
6. Panossian A., Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following dose administration. Phytother Res: 2005; 19 819 838
7. EMEA/HMPC/102655/2007. Reflection Paper on the Adaptogenic Concept. European Medicines Agency, London, 8 May 2008; Doc. Ref. EMEA/HMPC/102655/2007
8. Committee on herbal medicinal products (HMPC) Eleutherococcus senticosus (Ruppr. et Maxim.) Maxim., radix. Assessment report. London, 8 May 2008; Doc. Ref. EMEA/HMPC/232403/2006
9. Panossian A., Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol: 2009; 4 198 219
10. Smets EM A., Garssen B., Bonke B. et al. The multidimensional fatigue inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosomat Res: 1995; 39 315 325
11. Krampen G. Änderungssensitive Symptomliste zu Entspannungserleben, Wohlbefinden, Beschwerden- und Problembelastungen (Manual). Hogrefe Verlag GmbH & Co. KG: 2006
12. Schulz P., Schlotz W., Becker P. Trierer Inventar zum chronischen Stress. Hogrefe-Verlag GmbH & Co. KG: 2004
13. nd edition
14. nd edition
15. Zimmermann P., Fimm B. Testbatterie zur Erfassung von Aufmerksamkeitsstörungen. Freiburg Psytest: 1993; Version 1.02
16. Zimmermann P., Fimm B. A test battery for attentional performance. In: Leclercq M., Zimmermann P. (eds.). Applied Neuropsychology of Attention. Theory, Diagnosis and Rehabilitation.: 2002; 110 151
17. Scholz A. Konzentration im Alltag: Erleben und Leistung (Concentration in everyday life: experience and performance). PhD thesis, Technical University Dresden (Faculty of Mathematics and Natural Sciences); 2006
18. Harnett-Sheehan K., Sheehan D. V. Assessing treatment effects in clinical trials with the Discan metric of the Sheehan disability Scale. Int Clin Psychopharmacol: 2008; 23 70 83
19. Steyer R., Schwenkmezger P., Notz P. et al. Der mehrdimensionale Befindlichkeitsfragebogen (Multidimensional Mental State Questionnaire, MDBF) Manual. Hogrefe Verlag GmbH & Co. KG: 1997
20. Cheun R., Burkart M., Maier W. et al. Internal and external validity of the WHO well-being scale in the elderly general population. Acta Psychiatr Scand: 1999; 99 171 178
21. Parrott A. C., Hindmarch I. The Leeds Sleep Evaluation Questionnaire in psychopharmacological investigations - a review. Psychopharmacology: 1980; 71 173 179
22. Frey I., Berg A., Grathwohl D. et al. Freiburger Fragebogen zur körperlichen Aktivität - Entwicklung, Prüfung und Anwendung. Soz.-Präventivmed: 1999; 44 55 64
23. Boucsein W., Backs R. W. The Psychophysiology of Emotion, Arousal, and Personality: Methods and Models. In: Duffy V. G. (ed.). Handbook of Digital Human Modeling. Boca Raton CRC Press/Taylor & Francis: 2009; 35-1 35-18
24. Boucsein W. Physiologische Grundlagen und Meßmethoden der dermalen Aktivität. In: Rösler F. (ed.). Enzyklopädie der Psychologie, Bereich Psychophysiologie, Band 1: Grundlagen und Methoden der Psychophysiologie (551-623). Göttingen Hogrefe
25. Fries E., Dettenborn L., Kirschbaum C. The cortisol awakening response (CAR): Facts and future directions. Int J Psychophysiol: 2009; 72 67 73
26. Chida Y., Steptoe A. Cortisol awakening response and psychosocial factors: A systematic review and meta-analysis. Biol Psychiatry: 2008; 80 265 278
27. Kudielka B. M., Wüst S. Human models in acute and chronic stress: assessing determinants of individual hypothalamus-pituitary-adrenal axis activity and reactivity. Stress: 2010; 13 1 14
28. Olsson EM G., von Schéele B., Panossian A. G. A randomized, double-blind, placebo-controlled, parallel-group study of the standardized extract SHR-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med: 2009; 75 105 112
29. Cooley K., Szczurka O., Perris D. et al. Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974. PLoS ONE: 2009; 4 e6628 10.1371/journal.pone.0006628
30. Auddy B., Hazra J., Mitra A. et al. A standardized Withania Somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study. JANA: 2008; 11 50 56
31. Wust S., Wolf J., Hellhammer D. H. et al. The cortisol awakening response - normal values and confounds. Noise Health: 2000; 2 79 88
32. EMEA IC H., Topic E. 9. Note for Guidance on Statistical Principles for Clinical Trials. European Medicines Agency London September: 1998; Doc. Ref. EMEA/CPMP/ICH/363/96
33. McCall W. V., D'Agostino R. Jr, Rosenquist P. B. et al. Dissection of the factors driving the placebo effect in hypnotic treatment of depressed insomniacs. Sleep Med: 2011; 12 557 564
34. Kuo J., Chen K. W., Cheng I. S. et al. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Chin J Physiol: 2010; 53 105 111
35. Facchinetti F., Neri I., Tarabusi M. Eleuterococcus senticosus reduces cardiovascular stress response in healthy subjects: a randomized, placebo-controlled trial. Stress Health: 2002; 18 11 17
36. Cicero A. F., Derosa G., Brillante R. et al. Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Arch Gerontol Geriatr Suppl: 2004; 9 69 73
37. Hartz A. J., Bentler S., Noyes R. et al. Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol Med: 2004; 34 51 61
38. nd edition. Mary Ann Liebert New Rochelle: 2009; 16 32
39. Committee on herbal medicinal products (HMPC). Assessment report on Rhodiola rosea L., rhizoma et radix. EMA/HMPC/232100/2011, 12 July 2011
40. Ishaque S., Shamseer L., Bukutu C. et al. Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complement Altern Med: 2012; 12 70
41. Hung S. K., Perry R., Ernst E. The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials. Phytomedicine: 2011; 18 235 244
42. Edwards D., Heufelder A., Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS 1375 in subjects with life-stress symptoms - results of an open-label study. Phytotherapy Res: 2012; 26 1220 1225