A temperature-cured dissolvable gelatin microsphere-based cell carrier for chondrocyte delivery in a hydrogel scaffolding system

Acta Biomaterialia

Volumn 9, Issue 5, 2013, Pages 6459-6467

  Leong, Wenyan ^a   Lau, Ting Ting ^a   Wang, Dong An ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

Cartilage; Chondrocytes; Hydrogel; Microspheres; Tissue engineering

Indexed keywords

BODY FLUIDS; CELL ENGINEERING; CELLS; CURING; CYTOLOGY; EMULSIFICATION; HYDROGELS; MICROSPHERES; POLYMERASE CHAIN REACTION; SCAFFOLDS (BIOLOGY); TEMPERATURE;

CARTILAGE TISSUE ENGINEERING; CELL CARRIER; CELL DELIVERY; CELL-BE; CELL/B.E; CELL/BE; CHONDROCYTES; GELATIN MICROSPHERES; SCAFFOLDING SYSTEMS; TISSUES ENGINEERINGS;

CARTILAGE;

ALGINIC ACID; GELATIN; MICROSPHERE;

ARTICLE; CARTILAGE CELL; CELL ENCAPSULATION; CELL TRANSPLANTATION; CELL VIABILITY; CONTROLLED STUDY; HIGH TEMPERATURE; HYDROGEL; IMMUNOHISTOCHEMISTRY; LOW TEMPERATURE; PARTICLE SIZE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

EID: 84879889260     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.10.047     Document Type: Article

References (31)

1. S. Huang, G. Lu, Y. Wu, E. Jirigala, Y. Xu, and K. Ma Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair J Dermatol Sci 66 2012 29 36
2. X.Q. Wang, T. Yucel, Q. Lu, X. Hu, and D.L. Kaplan Silk nanospheres and microspheres from silk/pva blend films for drug delivery Biomaterials 31 2010 1025 1035
3. B.Y. Swamy, C.V. Prasad, C.L.N. Reddy, P. Sudhakara, I. Chung, and M.C.S. Subha Preparation of sodium alginate/poly(vinyl alcohol) blend microspheres for controlled release applications J Appl Polym Sci 125 2012 555 561
4. Y. Yang, N. Bajaj, P. Xu, K. Ohn, M.D. Tsifansky, and Y. Yeo Development of highly porous large PLGA microparticles for pulmonary drug delivery Biomaterials 30 2009 1947 1953
5. C.Z. Liang, H. Li, Y.Q. Tao, X.P. Zhou, Z.R. Yang, and Y.X. Xiao Dual delivery for stem cell differentiation using dexamethasone and bFGF in/on polymeric microspheres as a cell carrier for nucleus pulposus regeneration J Mater Sci Mater Med 23 2012 1097 1107
6. X.L. Zhang, Z.Y. Hui, D.X. Wan, H.T. Huang, J. Huang, and H. Yuan Alginate microsphere filled with carbon nanotube as drug carrier Int J Biol Macromol 47 2010 389 395
7. S.-W. Choi, Y. Zhang, Y.-C. Yeh, A. Lake Wooten, and Y. Xia Biodegradable porous beads and their potential applications in regenerative medicine J Mater Chem 22 2012 11442
8. K. Schrobback, T.J. Klein, M. Schuetz, Z. Upton, D.I. Leavesley, and J. Malda Adult human articular chondrocytes in a microcarrier-based culture system: expansion and redifferentiation J Orthop Res 29 2011 539 546
9. C. Wang, Y. Gong, Y. Lin, J. Shen, and D.-A. Wang A novel gellan gel-based microcarrier for anchorage-dependent cell delivery Acta Biomater 4 2008 1226 1234
10. Y.L. Zhou, Z.W. Yan, H.M. Zhang, W. Lu, S.Y. Liu, and X.H. Huang Expansion and delivery of adipose-derived mesenchymal stem cells on three microcarriers for soft tissue regeneration Tissue Eng Part A 17 2011 2981 2997
11. W. Chen, and Y.W. Tong PHBV microspheres as neural tissue engineering scaffold support neuronal cell growth and axon-dendrite polarization Acta Biomater 8 2012 540 548
12. C.J. Young, L.A. Poole-Warren, and P.J. Martens Combining submerged electrospray and UV photopolymerization for production of synthetic hydrogel microspheres for cell encapsulation Biotechnol Bioeng 109 2012 1561 1570
13. R. Ahmadi, N. Mordan, A. Forbes, and R.M. Day Enhanced attachment, growth and migration of smooth muscle cells on microcarriers produced using thermally induced phase separation Acta Biomater 7 2011 1542 1549
14. P. Sommar, S. Pettersson, C. Ness, H. Johnson, G. Kratz, and J.P. Junker Engineering three-dimensional cartilage- and bone-like tissues using human dermal fibroblasts and macroporous gelatine microcarriers J Plast Reconstr Aesthet Surg 63 2010 1036 1046
15. C.L. Franco, J. Price, and J.L. West Development and optimization of a dual-photoinitiator, emulsion-based technique for rapid generation of cell-laden hydrogel microspheres Acta Biomater 7 2011 3267 3276
16. R. Yao, R. Zhang, J. Luan, and F. Lin Alginate and alginate/gelatin microspheres for human adipose-derived stem cell encapsulation and differentiation Biofabrication 4 2012 025007
17. R. Ravichandran, S. Sundarrajan, J.R. Venugopal, S. Mukherjee, and S. Ramakrishna Advances in polymeric systems for tissue engineering and biomedical applications Macromol Biosci 12 2012 286 311
18. S. Efrat, and H.A. Russ Making β cells from adult tissues Trends Endocrin Met 23 2012 278 285
19. J.R.T. Lakey, P.W. Burridge, and A.M.J. Shapiro Technical aspects of islet preparation and transplantation Transpl Int 16 2003 613 632
20. J.Z. Tong, P. De Lagausie, V. Furlan, T. Cresteil, O. Bernard, and F. Alvarez Long-term culture of adult rat hepatocyte spheroids Exp Cell Res 200 1992 326 332
21. M. Benjamin, C.W. Archer, and J.R. Ralphs Cytoskeleton of cartilage cells Microsc Res Tech 28 1994 372 377
22. J. Itskovitz-Eldor, M. Schuldiner, D. Karsenti, A. Eden, O. Yanuka, and M. Amit Differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers Mol Med 6 2000 88 95
23. S.D. Sheridan, V. Surampudi, and R.R. Rao Analysis of embryoid bodies derived from human induced pluripotent stem cells as a means to assess pluripotency Stem Cells Int 2012
24. Y. Gong, K. Su, T.T. Lau, R. Zhou, and D.A. Wang Microcavitary hydrogel-mediating phase transfer cell culture for cartilage tissue engineering Tissue Eng Part A 16 2010 3611 3622
25. K. Su, T.T. Lau, W. Leong, Y. Gong, and D.-A. Wang Creating a living hyaline cartilage graft free from non-cartilaginous constituents: an intermediate role of a biomaterial scaffold Adv Funct Mater 22 2012 972 978
26. L.E. Freed, A.P. Hollander, I. Martin, J.R. Barry, R. Langer, and G. Vunjak-Novakovic Chondrogenesis in a cell-polymer-bioreactor system Exp Cell Res 240 1998 58 65
27. L. Freed, J. Marquis, A. Nohria, J. Emmanual, A. Mikos, and R. Langer Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers J Biomed Mater Res 27 1993 11 23
28. Y. Gong, C. Wang, R.C. Lai, K. Su, F. Zhang, and D. Wang An improved injectable polysaccharide hydrogel: modified gellan gum for long-term cartilage regeneration in vitro J Mater Chem 19 2009 1968 1977
29. S.S. Ng, K. Su, C. Li, M.B. Chan-Park, D.-A. Wang, and V. Chan Biomechanical study of the edge outgrowth phenomenon of encapsulated chondrocytic isogenous groups in the surface layer of hydrogel scaffolds for cartilage tissue engineering Acta Biomater 8 2012 244 252
30. R.F. Wynn, C.A. Hart, C. Corradi-Perini, L. O'Neill, C.A. Evans, and J. Wraith A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow Blood 104 2004 2643
31. 3 Vet Res 33 2002 383 396