Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis

Journal of Biomechanics

Volumn 46, Issue 4, 2013, Pages 723-730

  Inzana, Jason A ^a,b   Maher, Jason R ^c   Takahata, Masahiko ^b   Schwarz, Edward M ^b   Berger, Andrew J ^c   Awad, Hani A ^a,b  

^a University of Rochester   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

Author keywords

Bone mineral density; Bone quality; Fracture toughness; Inflammatory arthritis; Raman spectroscopy

Indexed keywords

BONE MINERAL DENSITY; BONE QUALITY; CRACK INITIATION AND PROPAGATION; INFLAMMATORY ARTHRITIS; MICROCOMPUTED TOMOGRAPHY; PARTIAL LEAST SQUARES REGRESSIONS (PLSR); PREDICTION MODEL; RHEUMATOID ARTHRITIS;

BONE; COMPUTERIZED TOMOGRAPHY; CRACK PROPAGATION; CRACKS; DISEASES; FORECASTING; LEAST SQUARES APPROXIMATIONS; MAMMALS; MINERALOGY; RAMAN SCATTERING; RAMAN SPECTROSCOPY; RISK ASSESSMENT;

FRACTURE TOUGHNESS;

COLLAGEN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BONE DENSITY; BONE FRAGILITY; BONE MINERALIZATION; BONE STRENGTH; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAPHYSIS; DISEASE MODEL; FEMUR FRACTURE; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOPOROSIS; PARTIAL LEAST SQUARES REGRESSION; PREDICTION; PRIORITY JOURNAL; RAMAN SPECTROMETRY; RHEUMATOID ARTHRITIS; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ARTHRITIS, RHEUMATOID; BIOMECHANICS; BONE DENSITY; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OSTEOPOROSIS; RISK FACTORS; SPECTRUM ANALYSIS, RAMAN; TUMOR NECROSIS FACTOR-ALPHA; X-RAY MICROTOMOGRAPHY;

EID: 84879883284     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2012.11.039     Document Type: Article

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