-
2
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006;355:2542-50. (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
3
-
-
77951473661
-
Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: Results from a randomised phase III trial (AVAiL)
-
Reck M, von Pawel J, Zatloukal P, Zatloukal P, Ramlau R, Gorbounova V, et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Ann Oncol 2010;21:1804-9.
-
(2010)
Ann Oncol
, vol.21
, pp. 1804-1809
-
-
Reck, M.1
Von Pawel, J.2
Zatloukal, P.3
Zatloukal, P.4
Ramlau, R.5
Gorbounova, V.6
-
4
-
-
0035813180
-
Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells
-
Everett AD, Stoops T, McNamara CA. Nuclear targeting is required for hepatoma-derived growth factor-stimulated mitogenesis in vascular smooth muscle cells. J Biol Chem 2001;276:37564-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 37564-37568
-
-
Everett, A.D.1
Stoops, T.2
McNamara, C.A.3
-
5
-
-
0028043462
-
Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein
-
Nakamura H, Izumoto Y, Kambe H, Kuroda T, Tori T, Kawamura K, et al. Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein. J Biol Chem 1994;269:25143-9.
-
(1994)
J Biol Chem
, vol.269
, pp. 25143-25149
-
-
Nakamura, H.1
Izumoto, Y.2
Kambe, H.3
Kuroda, T.4
Tori, T.5
Kawamura, K.6
-
6
-
-
13944258148
-
Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF)
-
DOI 10.1242/dev.01579
-
Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, et al. Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis ofg ene expression and study of the hepatoma-derived growth factor (HDGF). Development 2005; 132:415-27. (Pubitemid 40268290)
-
(2005)
Development
, vol.132
, Issue.2
, pp. 415-427
-
-
Lepourcelet, M.1
Tou, L.2
Cai, L.3
Sawada, J.-I.4
Lazar, A.J.F.5
Glickman, J.N.6
Williamson, J.A.7
Everett, A.D.8
Redston, M.9
Fox, E.A.10
Nakatani, Y.11
Shivdasani, R.A.12
-
7
-
-
15744383633
-
Hepatoma-derived growth factor: Significance of amino acid residues 81-100 in cell surface interaction and proliferative activity
-
DOI 10.1074/jbc.M414652200
-
Abouzied MM, El-Tahir HM, Prenner L, Haberlein H, Gieselmann V, Franken S. Hepatoma-derived growth factor. Significance of amino acid residues 81-100 in cell surface interaction and proliferative activity. J Biol Chem 2005;280:10945-54. (Pubitemid 40418396)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.12
, pp. 10945-10954
-
-
Abouzied, M.M.1
El-tahir, H.M.2
Prenner, L.3
Haberlein, H.4
Gieselmann, V.5
Franken, S.6
-
8
-
-
0346399553
-
Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor
-
DOI 10.1111/j.1349-7006.2003.tb01397.x
-
Okuda Y, Nakamura H, Yoshida K, Enomoto H, Uyama H, Hirotani T, et al. Hepatoma-derived growth factor induces tumorigenesis in vivo through both direct angiogenic activity and induction of vascular endothelial growth factor. Cancer Sci 2003;94:1034-41. (Pubitemid 38035516)
-
(2003)
Cancer Science
, vol.94
, Issue.12
, pp. 1034-1041
-
-
Okuda, Y.1
Nakamura, H.2
Yoshida, K.3
Enomoto, H.4
Uyama, H.5
Hirotani, T.6
Funamoto, M.7
Ito, H.8
Everett, A.D.9
Hada, T.10
Kawase, I.11
-
9
-
-
2442715235
-
Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor
-
DOI 10.1152/ajplung.00427.2003
-
Everett AD, Narron JV, Stoops T, Nakamura H, Tucker A. Hepatoma derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor. Am J Physiol Lung Cell Mol Physiol 2004;286:L1194-201. (Pubitemid 38656655)
-
(2004)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.286
, Issue.6
-
-
Everett, A.D.1
Narron, J.V.2
Stoops, T.3
Nakamura, H.4
Tucker, A.5
-
10
-
-
4344714365
-
Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer
-
DOI 10.1200/JCO.2004.02.080
-
Ren H, Tang X, Lee JJ, Feng L, Everett AD, Hong WK, et al. Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer. J Clin Oncol 2004;22:3230-7. (Pubitemid 41103677)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.16
, pp. 3230-3237
-
-
Ren, H.1
Tang, X.2
Lee, J.J.3
Feng, L.4
Everett, A.D.5
Waun, K.H.6
Khuri, F.R.7
Mao, L.8
-
11
-
-
31544454129
-
Down-regulation of hepatoma-derived growth factor inhibits anchorage-independent growth and invasion of non-small cell lung cancer cells
-
DOI 10.1158/0008-5472.CAN-04-3905
-
Zhang J, Ren H, Yuan P, Lang W, Zhang L, Mao L. Down-regulation of hepatoma-derived growth factor inhibits anchorage-independent growth and invasion of non-small cell lung cancer cells. Cancer Res 2006;66:18-23. (Pubitemid 43166002)
-
(2006)
Cancer Research
, vol.66
, Issue.1
, pp. 18-23
-
-
Zhang, J.1
Ren, H.2
Yuan, P.3
Lang, W.4
Zhang, L.5
Mao, L.6
-
12
-
-
66849104132
-
Antibodies targeting hepatoma-derived growth factor as a novel strategy in treating lung cancer
-
Ren H, Chu Z, Mao L. Antibodies targeting hepatoma-derived growth factor as a novel strategy in treating lung cancer. Mol Cancer Ther 2009;8:1106-12.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1106-1112
-
-
Ren, H.1
Chu, Z.2
Mao, L.3
-
13
-
-
33847613270
-
Gefitinib and chemotherapy combination studies in five novel human non small cell lung cancer xenografts. Evidence linking EGFR signaling to gefitinib antitumor response
-
DOI 10.1002/ijc.22364
-
Judde JG, Rebucci M, Vogt N, de Gremoux P, Livartowski A, Chapelier A, et al. Gefitinib and chemotherapy combination studies in five novel human non small cell lung cancer xenografts. Evidence linking EGFR signaling to gefitinib antitumor response. Int J Cancer 2007;120:1579-90. (Pubitemid 46355397)
-
(2007)
International Journal of Cancer
, vol.120
, Issue.7
, pp. 1579-1590
-
-
Judde, J.-G.1
Rebucci, M.2
Vogt, N.3
De Cremoux, P.4
Livartowski, A.5
Chapelier, A.6
Tran-Perennou, C.7
Boye, K.8
Defrance, R.9
Poupon, M.-F.10
Bras-Goncalves, R.-A.11
-
14
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000;92:205-16. (Pubitemid 30099779)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.3
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
Wanders, J.4
Kaplan, R.S.5
Rubinstein, L.6
Verweij, J.7
Van Glabbeke, M.8
Van Oosterom, A.T.9
Christian, M.C.10
Gwyther, S.G.11
-
15
-
-
77953430456
-
Heterotransplant mouse model cohorts of human malignancies: A novel platform for systematic preclinical efficacy evaluation of drugs (SPEED)
-
Pathak AK, Bhutani M, Saintigny P, Mao L. Heterotransplant mouse model cohorts of human malignancies: a novel platform for systematic preclinical efficacy evaluation of drugs (SPEED). Am J Transl Res 2009;1:16-22.
-
(2009)
Am J Transl Res
, vol.1
, pp. 16-22
-
-
Pathak, A.K.1
Bhutani, M.2
Saintigny, P.3
Mao, L.4
-
16
-
-
84864286442
-
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors
-
Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012;487:505-9.
-
(2012)
Nature
, vol.487
, pp. 505-509
-
-
Wilson, T.R.1
Fridlyand, J.2
Yan, Y.3
Penuel, E.4
Burton, L.5
Chan, E.6
-
17
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Davis A, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012;487:500-4.
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
Morikawa, T.2
Shee, K.3
Barzily-Rokni, M.4
Qian, Z.R.5
Davis, A.6
-
18
-
-
0034488466
-
Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice
-
Perez-Soler R, Kemp B, Wu QP, Mao L, Gomez J, Zeleniuch-Jacquotte A, et al. Response and determinants of sensitivity to paclitaxel in human non-small cell lung cancer tumors heterotransplanted in nude mice. Clin Cancer Res 2000;6:4932-8. (Pubitemid 32110439)
-
(2000)
Clinical Cancer Research
, vol.6
, Issue.12
, pp. 4932-4938
-
-
Perez-Soler, R.1
Kemp, B.2
Qing, P.W.3
Mao, L.4
Gomez, J.5
Zeleniuch-Jacquotte, A.6
Yee, H.7
Jin, S.L.8
Jagirdar, J.9
Yi, H.L.10
-
19
-
-
78751471036
-
The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer
-
John T, Kohler D, Pintilie M, Pham NA, Li M, Panchal D, et al. The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer. Clin Cancer Res 2011;17:134-41.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 134-141
-
-
John, T.1
Kohler, D.2
Pintilie, M.3
Pham, N.A.4
Li, M.5
Panchal, D.6
-
20
-
-
77649104920
-
First-line systemic chemotherapy in the treatment of advanced non-small cell lung cancer: A systematic review
-
Goffin J, Lacchetti C, Ellis PM, Ung YC, Evans WK. First-line systemic chemotherapy in the treatment of advanced non-small cell lung cancer: a systematic review. J Thorac Oncol 2010;5:260-74.
-
(2010)
J Thorac Oncol
, vol.5
, pp. 260-274
-
-
Goffin, J.1
Lacchetti, C.2
Ellis, P.M.3
Ung, Y.C.4
Evans, W.K.5
-
21
-
-
82355186665
-
Wnt/b-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming
-
Miki T, Yasuda SY, Kahn M. Wnt/b-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming. Stem Cell Rev 2011;7:836-46.
-
(2011)
Stem Cell Rev
, vol.7
, pp. 836-846
-
-
Miki, T.1
Yasuda, S.Y.2
Kahn, M.3
-
22
-
-
84855425160
-
Interactions between cancer stem cells and their niche govern metastatic colonization
-
Malanchi I, Santamaria-Martinez A, Susanto E, Peng H, Lehr HA, Delalove JF, et al. Interactions between cancer stem cells and their niche govern metastatic colonization. Nature 2011;481:85-9.
-
(2011)
Nature
, vol.481
, pp. 85-89
-
-
Malanchi, I.1
Santamaria-Martinez, A.2
Susanto, E.3
Peng, H.4
Lehr, H.A.5
Delalove, J.F.6
-
23
-
-
79953746223
-
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
-
Shin K, Lee J, Guo N, Kin J, Lim A, Qu L, et al. Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature 2011;472:110-4.
-
(2011)
Nature
, vol.472
, pp. 110-114
-
-
Shin, K.1
Lee, J.2
Guo, N.3
Kin, J.4
Lim, A.5
Qu, L.6
-
24
-
-
2342441403
-
The stroma as a crucial target in rat mammary gland carcinogenesis
-
DOI 10.1242/jcs.01000
-
Maffini MV, Soto AM, Calabro JM, Ucci AA, Sonnenschein C. The stroma as a crucial target in rat mammary gland carcinogenesis. J Cell Sci 2004;117:1495-502. (Pubitemid 38559824)
-
(2004)
Journal of Cell Science
, vol.117
, Issue.8
, pp. 1495-1502
-
-
Maffini, M.V.1
Soto, A.M.2
Calabro, J.M.3
Ucci, A.A.4
Sonnenschein, C.5
-
25
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
DOI 10.1016/j.cell.2005.02.034, PII S0092867405002370
-
Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005;121:335-48. (Pubitemid 40692295)
-
(2005)
Cell
, vol.121
, Issue.3
, pp. 335-348
-
-
Orimo, A.1
Gupta, P.B.2
Sgroi, D.C.3
Arenzana-Seisdedos, F.4
Delaunay, T.5
Naeem, R.6
Carey, V.J.7
Richardson, A.L.8
Weinberg, R.A.9
-
26
-
-
0036843937
-
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
-
DOI 10.1038/ng1013
-
Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 2002;32:355-7. (Pubitemid 35266108)
-
(2002)
Nature Genetics
, vol.32
, Issue.3
, pp. 355-357
-
-
Kurose, K.1
Gilley, K.2
Matsumoto, S.3
Watson, P.H.4
Zhou, X.-P.5
Eng, C.6
-
27
-
-
23044499067
-
Distinct epigenetic changes in the stromal cells of breast cancers
-
DOI 10.1038/ng1596
-
Hu M, Yao J, Cai L, Bachman KE, van den Brule F, Velculescu V, et al. Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet 2005;37:899-905. (Pubitemid 41077119)
-
(2005)
Nature Genetics
, vol.37
, Issue.8
, pp. 899-905
-
-
Hu, M.1
Yao, J.2
Cai, L.3
Bachman, K.E.4
Van Den, B.F.5
Velculescu, V.6
Polyak, K.7
-
28
-
-
69449096005
-
Heterogeneity in cancer: Cancer stem cells versus clonal evolution
-
Shackleton M, Quintana E, Fearon ER, Morrison SJ. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell 2009;138:822-9.
-
(2009)
Cell
, vol.138
, pp. 822-829
-
-
Shackleton, M.1
Quintana, E.2
Fearon, E.R.3
Morrison, S.J.4
-
29
-
-
16844368698
-
Tumour stem cells and drug resistance
-
DOI 10.1038/nrc1590
-
Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5:275-84. (Pubitemid 40488633)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.4
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
30
-
-
45549093647
-
Survival of the fittest: Cancer stem cells in therapeutic resistance and angiogenesis
-
Eyler CE, Rich JN. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol 2008;26:2839-45.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2839-2845
-
-
Eyler, C.E.1
Rich, J.N.2
-
31
-
-
44049100934
-
Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy
-
Li X, Lewis MT, Huang J, Gutierrez C, Osborne CK, Wu MF, et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J Natl Cancer Inst 2008;100:672-9.
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 672-679
-
-
Li, X.1
Lewis, M.T.2
Huang, J.3
Gutierrez, C.4
Osborne, C.K.5
Wu, M.F.6
-
32
-
-
84865222310
-
Defining the mode of tumour growth by clonal analysis
-
Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C. Defining the mode of tumour growth by clonal analysis. Nature 2012;488:527-30.
-
(2012)
Nature
, vol.488
, pp. 527-530
-
-
Driessens, G.1
Beck, B.2
Caauwe, A.3
Simons, B.D.4
Blanpain, C.5
-
33
-
-
84865203983
-
A restricted cell population propagates glioblastoma growth after chemotherapy
-
Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie SG, et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012;488:522-6.
-
(2012)
Nature
, vol.488
, pp. 522-526
-
-
Chen, J.1
Li, Y.2
Yu, T.S.3
McKay, R.M.4
Burns, D.K.5
Kernie, S.G.6
-
34
-
-
84864854371
-
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas
-
Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 2012;337:730-5.
-
(2012)
Science
, vol.337
, pp. 730-735
-
-
Schepers, A.G.1
Snippert, H.J.2
Stange, D.E.3
Van Den Born, M.4
Van Es, J.H.5
Van De Wetering, M.6
-
36
-
-
79958011688
-
Stem cell and lung cancer development: Blaming the Wnt, Hh and Notch signalling pathway
-
García Campelo MR, Alonso Curbera G, Aparicio Gallego G, Grande Pulido E, Antón Aparicio LM. Stem cell and lung cancer development: blaming the Wnt, Hh and Notch signalling pathway. Clin Transl Oncol 2011;13:77-83.
-
(2011)
Clin Transl Oncol
, vol.13
, pp. 77-83
-
-
García Campelo, M.R.1
Alonso Curbera, G.2
Aparicio Gallego, G.3
Grande Pulido, E.4
Antón Aparicio, L.M.5
-
37
-
-
77956331142
-
Notch signaling in the regulation of stem cell self-renewal and differentiation
-
Liu J, Sato C, Cerletti M, Wagers A. Notch signaling in the regulation of stem cell self-renewal and differentiation. Curr Top Dev Biol 2010;92:367-409.
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 367-409
-
-
Liu, J.1
Sato, C.2
Cerletti, M.3
Wagers, A.4
-
38
-
-
0242691647
-
Histologic Assessment of Non-Small Cell Lung Carcinoma after Neoadjuvant Therapy
-
DOI 10.1097/01.MP.0000096041.13859.AB
-
Liu-Jarin X, Stoopler MB, Raftopoulos H, Ginsburg M, Gorenstein L, Borczuk AC. Histologic assessment of non-small cell lung carcinoma after neoadjuvant therapy. Mod Pathol 2003;16:1102-8. (Pubitemid 37414204)
-
(2003)
Modern Pathology
, vol.16
, Issue.11
, pp. 1102-1108
-
-
Liu-Jarin, X.1
Stoopler, M.B.2
Raftopoulos, H.3
Ginsburg, M.4
Gorenstein, L.5
Borczuk, A.C.6
-
39
-
-
84856934228
-
Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy
-
Brennen WN, Isaacs JT, Denmeade SR. Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy. Mol Cancer Ther 2012;11:257-66.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 257-266
-
-
Brennen, W.N.1
Isaacs, J.T.2
Denmeade, S.R.3
-
40
-
-
84861995298
-
Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells
-
Nishimura K, Semba S, Aoyagi K, Sasaki H, Yokozaki H. Mesenchymal stem cells provide an advantageous tumor microenvironment for the restoration of cancer stem cells. Pathobiology 2012;79:290-306.
-
(2012)
Pathobiology
, vol.79
, pp. 290-306
-
-
Nishimura, K.1
Semba, S.2
Aoyagi, K.3
Sasaki, H.4
Yokozaki, H.5
-
41
-
-
80053904142
-
Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
-
Dieter SM, Ball CR, Hoffmann CM, Nowrouzi A, Herbst F, Zavidij O, et al. Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell 2011;9:357-65.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 357-365
-
-
Dieter, S.M.1
Ball, C.R.2
Hoffmann, C.M.3
Nowrouzi, A.4
Herbst, F.5
Zavidij, O.6
|