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Volumn 141, Issue 3, 2013, Pages 3183-3191

Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol

Author keywords

Ginger; Gingerol; Microglia; Neuroinflammation; Shogaol; Zingerone

Indexed keywords

GENE EXPRESSION; IMMUNOLOGY; NITRIC OXIDE;

EID: 84879829492     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.06.010     Document Type: Article
Times cited : (106)

References (30)
  • 1
    • 80054059652 scopus 로고    scopus 로고
    • Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: Reverse pharmacology and bedside to bench approach
    • Aggarwal, B. B., Prasad, S., Reuter, S., Kannappan, R., Yadev, V. R., Park, B., et al. (2011). Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: Reverse pharmacology and bedside to bench approach. Current Drug Targets, 12(11), 1595-1653.
    • (2011) Current srug targets , vol.12 , Issue.11 , pp. 1595-1653
    • Aggarwal, B.B.1    Prasad, S.2    Reuter, S.3    Kannappan, R.4    Yadev, V.R.5    Park, B.6
  • 2
    • 37349127807 scopus 로고    scopus 로고
    • Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research
    • DOI 10.1016/j.fct.2007.09.085, PII S0278691507004243
    • Ali, B. H., Blunden, G., Tanira, M. O., & Nemmar, A. (2008). Some phytochemical, pharmacological and toxicological propertie s of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, 46, 409-420. (Pubitemid 350297543)
    • (2008) Food and Chemical Toxicology , vol.46 , Issue.2 , pp. 409-420
    • Ali, B.H.1    Blunden, G.2    Tanira, M.O.3    Nemmar, A.4
  • 4
    • 79952167196 scopus 로고    scopus 로고
    • Inhibitors of microglial neurotoxicity: Focus on natural products
    • Choi, D. K., Koppula, S., & Suk, K. (2011). Inhibitors of microglial neurotoxicity: Focus on natural products. Molecules, 16, 1021-1043.
    • (2011) Molecules , vol.16 , pp. 1021-1043
    • Choi, D.K.1    Koppula, S.2    Suk, K.3
  • 6
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010). Mechanisms underlying inflammation in neurodegeneration. Cell, 140, 918-934.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 7
    • 22444431608 scopus 로고    scopus 로고
    • Ginger - An herbal medicinal product with broad anti-inflammatory actions
    • DOI 10.1089/jmf.2005.8.125
    • Grzanna, R., Lindmark, L., & Frondoza, C. G. (2005). Ginger-An herbal medicinal product with broad anti-inflammatory actions. Journal of Medicinal Food, 8(2), 125-132. (Pubitemid 41008974)
    • (2005) Journal of Medicinal Food , vol.8 , Issue.2 , pp. 125-132
    • Grzanna, R.1    Lindmark, L.2    Frondoza, C.G.3
  • 8
    • 84861975965 scopus 로고    scopus 로고
    • 6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection
    • Ha, S. K., Moon, E., Ju, M. S., Kim, D. H., Ryu, J. H., Oh, M. S., et al. (2012). 6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection. Neuropharmacology, 63, 211-223.
    • (2012) Neuropharmacology , vol.63 , pp. 211-223
    • Ha, S.K.1    Moon, E.2    Ju, M.S.3    Kim, D.H.4    Ryu, J.H.5    Oh, M.S.6
  • 9
    • 26844499175 scopus 로고    scopus 로고
    • Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/ electrospray ionization mass spectrometry
    • DOI 10.1002/rcm.2140
    • Jiang, H., Só ly om, A. M., Timmermann, B. N., & Gang, D. R. (2005). Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/ electrospray ionization mass spectrometry. Rapid Commu nication in Mass Spectrometry, 19, 2957-2964. (Pubitemid 41454614)
    • (2005) Rapid Communications in Mass Spectrometry , vol.19 , Issue.20 , pp. 2957-2964
    • Jiang, H.1    Solyom, A.M.2    Timmermann, B.N.3    Gang, D.R.4
  • 10
    • 59849106109 scopus 로고    scopus 로고
    • Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats
    • Jiang, S. Z., Wang, N. S., & Mi, S. Q. (2008). Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharmaceutics and Drug Disposition, 29(9), 529-537.
    • (2008) Biopharmaceutics and Drug Disposition , vol.29 , Issue.9 , pp. 529-537
    • Jiang, S.Z.1    Wang, N.S.2    Mi, S.Q.3
  • 11
    • 3242755759 scopus 로고    scopus 로고
    • 2 production
    • DOI 10.1016/j.phytochem.2004.06.008, PII S0031942204002572
    • Jolad, S. D., Lantz, R. C., Solyom, A. M., Chen, G. J., Bates, R. B., & Timmermann, B. N. (2004). Fresh organically grown ginger (Zingiber officinale): Composition and effects on LPS-induced PGE2 production. Phytochemistry, 65, 1937-1954. (Pubitemid 38981684)
    • (2004) Phytochemistry , vol.65 , Issue.13 , pp. 1937-1954
    • Jolad, S.D.1    Lantz, R.C.2    Solyom, A.M.3    Chen, G.J.4    Bates, R.B.5    Timmermann, B.N.6
  • 12
    • 67349236219 scopus 로고    scopus 로고
    • Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the product ion of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NFkappaB pathway
    • Jung, H. W., Yoon, C.-H., Park, K. M., Han, H. S., & Park, Y.-K. (2009). Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the product ion of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NFkappaB pathway. Food and Chemical Toxicology, 47(6), 1190-1197.
    • (2009) Food and Chemical Toxicology , vol.47 , Issue.6 , pp. 1190-1197
    • Jung, H.W.1    Yoon, C.-H.2    Park, K.M.3    Han, H.S.4    Park, Y.-K.5
  • 13
    • 1242293891 scopus 로고    scopus 로고
    • Side-chain length is important for shogaols in protecting neuronal cells from amyloid insult
    • DOI 10.1016/j.bmcl.2003.12.041
    • Kim, D. S. H. L., & Kim, J. Y. (2004). Side-ch ain length is important for shogaols in protecting neuronal cells from b-amyloid insult. Bioorganic and Medicinal Chemistry Letters, 14, 1287-1289. (Pubitemid 38229872)
    • (2004) Bioorganic and Medicinal Chemistry Letters , vol.14 , Issue.5 , pp. 1287-1289
    • Kim, D.S.H.L.1    Kim, J.Y.2
  • 14
    • 84861430483 scopus 로고    scopus 로고
    • An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe)
    • Kubra, I. R., & Rao, L. J. M. (2012). An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe). Critical Reviews in Food Science and Nutrition, 52(8), 651-688.
    • (2012) Critical Reviews in Food Science and Nutrition , vol.52 , Issue.8 , pp. 651-688
    • Kubra, I.R.1    Rao, L.J.M.2
  • 15
    • 33846394444 scopus 로고    scopus 로고
    • The effect of extracts from ginger rhizome on inflammatory mediator production
    • DOI 10.1016/j.phymed.2006.03.003, PII S0944711306000493
    • Lantz, R. C., Chen, G. J., Sarihan, M., Solyom, A. M., Jolad, S. D., & Timmermann, B. N. (2007). The effect of extracts from ginger rhizome on inflammatory mediator production. Phytomedicine, 14 , 123-128. (Pubitemid 46136942)
    • (2007) Phytomedicine , vol.14 , Issue.2-3 , pp. 123-128
    • Lantz, R.C.1    Chen, G.J.2    Sarihan, M.3    Solyom, A.M.4    Jolad, S.D.5    Timmermann, B.N.6
  • 16
    • 63349089720 scopus 로고    scopus 로고
    • 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macropha ges
    • Lee, T.-Y., Lee, K.-C., Chen, S.-Y., & Chang, H.-H. (2009). 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macropha ges. Biochemical and Biophysical Research Communications, 382, 134-139.
    • (2009) Biochemical and Biophysical Research Communications , vol.382 , pp. 134-139
    • Lee, T.-Y.1    Lee, K.-C.2    Chen, S.-Y.3    Chang, H.-H.4
  • 17
    • 0037215645 scopus 로고    scopus 로고
    • Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic intervention
    • DOI 10.1124/jpet.102.035048
    • Liu, B., & Hong, J. S. (2003). Role of microglia in inflammation-mediated neurodegenerative diseases: Mechanisms and strategies for therapeutic int ervention. The Journal of Pharmacology and Experimental Therapeutics, 304, 1-7. (Pubitemid 36008905)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.304 , Issue.1 , pp. 1-7
    • Liu, B.1    Hong, J.-S.2
  • 20
    • 78751591242 scopus 로고    scopus 로고
    • RP-HPLC analysis of phenolic antioxidant compound 6-gingerol from different ginger cultivars
    • Pawar, N., Pai, S., Nimbalkar, M., & Dixit, G. (2011). RP-HPLC analysis of phenolic antioxidant com pound 6-gingerol from different ginger cultivars. Food Chemistry, 126, 1330-1336.
    • (2011) Food Chemistry , vol.126 , pp. 1330-1336
    • Pawar, N.1    Pai, S.2    Nimbalkar, M.3    Dixit, G.4
  • 21
    • 72449141505 scopus 로고    scopus 로고
    • Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols
    • Sang, S., Hong, J., Wu, H., Liu, J., Yang, C., Pan, M. H., et al. (2009). Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. Journal of Agricultural and Food Chemistry, 57, 10645-10650.
    • (2009) Journal of Agricultural and Food Chemistry , vol.57 , pp. 10645-10650
    • Sang, S.1    Hong, J.2    Wu, H.3    Liu, J.4    Yang, C.5    Pan, M.H.6
  • 22
    • 33947379619 scopus 로고    scopus 로고
    • Cancer preventive properties of ginger: A brief review
    • DOI 10.1016/j.fct.2006.11.002, PII S027869150600322X
    • Shukla, Y., & Singh, M. (2007). Cancer preventive properties of ginger: A brief review. Food and Chemical Toxicology, 45, 683-690. (Pubitemid 46452881)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.5 , pp. 683-690
    • Shukla, Y.1    Singh, M.2
  • 23
    • 47849120398 scopus 로고    scopus 로고
    • Challenges for research on polyphenols from foods in Alzheimer's disease: Bioavailability, metabolism, and cellular and molecular mechanisms
    • DOI 10.1021/jf0735073
    • Singh, M., Arseneault, M., Sanderson, T., Murthy, V., & Ramassamy, C. (2008). Challenges for research on polyphenols from foods in Alzheimers disease: Bioavailability, metabolism, and cellular and molecular mechanisms. Journal of Agricultural and Food Chemistry, 56(13), 4855-4873. (Pubitemid 352039080)
    • (2008) Journal of Agricultural and Food Chemistry , vol.56 , Issue.13 , pp. 4855-4873
    • Singh, M.1    Arseneault, M.2    Sanderson, T.3    Murthy, V.4    Ramassamy, C.5
  • 24
    • 33846223213 scopus 로고    scopus 로고
    • Antioxidant activity of a ginger extract (Zingiber officinale)
    • DOI 10.1016/j.foodchem.2006.06.023, PII S030881460600481X
    • Stoilova, I., Krastanov, A., Stoyanova, A. , Denev, P., & Gargova, S. (2007). Antioxidant activity of a ginger extract (Zingiber officinale). Food Chemistry, 102, 764-770. (Pubitemid 46108279)
    • (2007) Food Chemistry , vol.102 , Issue.3 , pp. 764-770
    • Stoilova, I.1    Krastanov, A.2    Stoyanova, A.3    Denev, P.4    Gargova, S.5
  • 25
    • 0035574475 scopus 로고    scopus 로고
    • Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells
    • DOI 10.1006/bioo.2001.1208
    • Tjendraputra, E., Tran, V. H., Liu-Brennan, D., Roufogalis, B. D., & Duke, C. C. (2001). Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorganic Chemistry, 29, 156-163. (Pubitemid 34226237)
    • (2001) Bioorganic Chemistry , vol.29 , Issue.3 , pp. 156-163
    • Tjendraputra, E.1    Tran, V.H.2    Liu-Brennan, D.3    Roufogalis, B.D.4    Duke, C.C.5
  • 26
    • 33847617069 scopus 로고    scopus 로고
    • Effect of 6-Gingerol on Pro-Inflammatory Cytokine Production and Costimulatory Molecule Expression in Murine Peritoneal Macrophages
    • DOI 10.1016/j.jss.2006.07.051, PII S0022480406004227
    • Tripathi, S., Maier, K. G., Bruch, D., & Kittur D. S. (2007). Effect of 6-gingerol on proinflammatory cytokine production and costimulatory molecule expression in murine peritoneal macrophages. Journal of Surgical Research, 138, 209-213. (Pubitemid 46365725)
    • (2007) Journal of Surgical Research , vol.138 , Issue.2 , pp. 209-213
    • Tripathi, S.1    Maier, K.G.2    Bruch, D.3    Kittur, D.S.4
  • 27
    • 79151481756 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale)
    • van Breemen, R. B., Tao, Y., & Li, W. (2011). Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia, 82(1), 38-43.
    • (2011) Fitoterapia , vol.82 , Issue.1 , pp. 38-43
    • Van Breemen, R.B.1    Tao, Y.2    Li, W.3
  • 28
    • 26944464241 scopus 로고    scopus 로고
    • Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger
    • DOI 10.1016/j.jep.2005.05.043, PII S0378874105003697
    • Wei, Q.-Y., Ma, J.-P., Cai, Y.-J., Yang, L., & Liu, Z.-L. (2005). Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger. Journal of Ethnopharmacology, 102(2), 177-184. (Pubitemid 41483554)
    • (2005) Journal of Ethnopharmacology , vol.102 , Issue.2 , pp. 177-184
    • Wei, Q.-Y.1    Ma, J.-P.2    Cai, Y.-J.3    Yang, L.4    Liu, Z.-L.5
  • 29
    • 84876584371 scopus 로고    scopus 로고
    • Protective effects of ginger root extract on Alzheimer s disease-induced behavioural dysfunction in rats
    • Zeng, G.-F., Zhang, Z.-Y., Lu, L., Xiao, D.-Q, Zong, S.-H., & He, J.-M. (2013). Protective effects of ginger root extract on Alzheimer s disease-induced behavioural dysfunction in rats. Rejuvenation Research, 16(2), 124-133.
    • (2013) Rejuvenation Research , vol.16 , Issue.2 , pp. 124-133
    • Zeng, G.-F.1    Zhang, Z.-Y.2    Lu, L.3    Xiao, D.-Q.4    Zong, S.-H.5    He, J.-M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.