The beneficial effect of ginsenoside Rg1 on Schwann cells subjected to hydrogen peroxide induced oxidative injury

International Journal of Biological Sciences

Volumn 9, Issue 6, 2013, Pages 624-636

  Ma, Junxiong ^a   Liu, Jun ^a   Wang, Qi ^a   Yu, Hailong ^a   Chen, Yu ^a   Xiang, Liangbi ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

Ginsenoside Rg1 (GRg1); Hydrogen peroxide; Oxidative injury; Schwann cell

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GINSENOSIDE; GINSENOSIDE RG 1; HYDROGEN PEROXIDE; NERVE GROWTH FACTOR; PRIMER DNA;

ANIMAL; APOPTOSIS; ARTICLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GINSENOSIDE RG1 (GRG1); METABOLISM; NUCLEOTIDE SEQUENCE; OXIDATIVE INJURY.; OXIDATIVE STRESS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCHWANN CELL; SECRETION (PROCESS); SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

GINSENOSIDE RG1 (GRG1); HYDROGEN PEROXIDE; OXIDATIVE INJURY.; SCHWANN CELL;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GINSENOSIDES; HYDROGEN PEROXIDE; NERVE GROWTH FACTOR; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; SCHWANN CELLS;

RATTUS;

EID: 84879826474     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.5885     Document Type: Article

References (37)

1. Chen XC, Chen Y, Zhu YG, Fang F, Chen LM. Protective effect of gin-senoside Rg1 against MPTP-induced apoptosis in mouse substantianigra neurons. Acta Pharmacol Sin. 2002; 23(9): 829-34. [PubMed: 12230953]
2. Chen XC, Zhou YC, Chen Y, Zhu YG, Fang F, Chen LM. Ginsenoside Rg1 reduces MPTP-induced substantianigra neuron loss by suppressing ox-idative stress. Acta Pharmacol Sin. 2005; 26(1): 56-62. [PubMed: 15659115]
3. Chen XC, Zhu YG, Wang XZ, Zhu LA, Huang C. Protective effect of ginsenoside Rg1 on dopamine-induced apoptosis in PC12 cells. Acta Pharmacol Sin. 2001; 22(8): 673-8. [PubMed: 11749836]
4. Chen XC, Zhu YG, Zhu LA, Huang C, Chen Y, Chen LM, Fang F, Zhou YC, Zhao CH. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol. 2003; 473(1): 1-7. [PubMed: 12877931]
5. Leung KW, Yung KK, Mak NK, Chan YS, Fan TP, Wong RN. Neuro-protective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity. Neuropharmacology. 2007; 52(3): 827-35. [PubMed: 17123556]
6. Lu MC, Lai TY, Hwang JM, Chen HT, Chang SH, Tsai FJ, Wang HL, Lin CC, Kuo WW, Huang CY. Proliferation-and migration-enhancing effects of ginseng and ginsenoside Rg1 through IGF-I-and FGF-2-signaling pathways on RSC96 Schwann cells. Cell BiochemFunct. 2009; 27(4): 186-92. [PubMed: 19326380]
7. Ma J, Li W, Tian R, Lei W. Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury. Neurosci Lett. 2010; 478(2): 66-71. [PubMed: 20438804]
8. Frostick SP, Yin Q, Kemp GJ. Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery. 1998; 18(7): 397-405. [PubMed: 9880154]
9. Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT, Bunge MB. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med. 2004; 10(6): 610-6. [PubMed: 15156204]
10. Martin LJ, Kaiser A, Price AC. Motor neuron degeneration after sciatic nerve avulsion in adult rat evolves with oxidative stress and is apoptosis. J Neurobiol. 1999; 40(2): 185-201. [PubMed: 10413449]
11. Martin LJ, Price AC, McClendon KB, Al-Abdulla NA, Subramaniam JR, Wong PC, Liu Z. Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phos-phorylation and subcellular redistribution of death proteins. J Neuro-chem. 2003; 85(1): 234-47. [PubMed: 12641745]
12. Kobayashi M, Ishibashi S, Tomimitsu H, Yokota T, Mizusawa H. Proliferating immature Schwann cells contribute to nerve regeneration after ischemic peripheral nerve injury. Neuropathol Exp Neurol. 2012; 71(6): 511-9. [PubMed: 22588387]
13. Fukunaga M, Miyata S, Liu BF, Miyazaki H, Hirota Y, Higo S, Hamada Y, Ueyama S, Kasuga M. Methylglyoxal induces apoptosis through activation of p38 MAPK in rat Schwann cells. Biochem Biophys Res Commun. 2004; 320(3): 689-95. [PubMed: 15240103]
14. Iida H, SchmeichelAM, Wang Y, Schmelzer JD, Low PA. Schwann cell is a target in ischemia-reperfusion injury to peripheral nerve. Muscle Nerve. 2004; 30(6): 761-6. [PubMed: 15468335]
15. Shokouhi G, Tubbs RS, Shoja MM, Roshangar L, Mesgari M, Ghor-banihaghjo A, Ahmadi N, Sheikhzadeh F, Rad JS. The effects of aerobic exercise training on the age-related lipid peroxidation, Schwann cell apoptosis and ultrastructural changes in the sciatic nerve of rats. Life Sci. 2008; 82(15/16): 840-6. [PubMed: 18336840]
16. Gao QG, Chen WF, Xie JX, Wong MS. Ginsenoside Rgl protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. J Neurochem. 2009; 109(5): 1338-47. [PubMed: 19476546]
17. Ge KL, Chen WF, Xie JX, Wong MS. Ginsenoside Rgl protects against 6-OHDA-induced toxicity in MES23.5 cells via Akt and ERK signaling pathways. J Ethnopharmacol. 2010; 127(1): 118-23. [PubMed: 19799986]
18. Liu Q, Kou JP, Yu BY. Ginsenoside Rgl protects against hydrogen peroxide-induced cell death in PC12 cells via inhibiting NF-kB activation. Neurochem Int. 2011; 58(1): 119-25. [PubMed: 21078355]
19. Yu SH, Huang HY, Korivi M, Hsu MF, Huang CY, Hou CW, Chen CY, Kao CL, Lee RP, Lee SD, Kuo CH. Oral Rgl supplementation strengthens antioxidant defense system against exercise-induced oxidative stress in rat skeletal muscles. J IntSoc Sports Nutr. 2012; 9(1): 23. [PubMed: 22607394]
20. Korivi M, Hou CW, Huang CY, Lee SD, Hsu MF, Yu SH, Chen CY, Liu YY, Kuo CH. Ginsenoside-Rgl Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats. Evid Based Complement Al-ternat Med. 2012; 2012: 932165. [PubMed: 21941591]
21. Liang W, Ge S, Yang L, Yang M, Ye Z, Yan M, Du J, Luo Z. Ginsenosides Rbl and Rgl promote proliferation and expression of neurotrophic factors in primary Schwann cell cultures. Brain Res. 2010; 1357: 19-25. [PubMed: 20682297]
22. Huang J, Hu X, Lu L, Ye Z, Zhang Q, Luo Z. Electrical regulation of Schwann cells using conductive polypyrrole/chitosan polymers. J Bio-med Mater Res A. 2010; 93(1): 164-74. [PubMed: 19536828]
23. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab. 2001; 21(1): 2-14. [PubMed: 11149664]
24. Lewén A, Matz P, Chan PH. Free radical pathways in CNS injury. J Neurotrauma. 2000; 17(10): 871-90. [PubMed: 11063054]
25. Loh KP, Huang SH, De Silva R, Tan BK, Zhu YZ. Oxidative stress: apoptosis in neuronal injury. Curr Alzheimer Res. 2006; 3(4): 327-37. [PubMed: 17017863]
26. Luo X, Chen B, Zheng R, Lin P, Li J, Chen H. Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells. NeurosciLett. 2010; 485(1): 60-4. [PubMed: 20813162]
27. Bowe CM, Hildebrand C, Kocsis JD, Waxman SG. Morphological and physiological properties of neurons after long-term axonal regeneration: observations on chronic and delayed sequelae of peripheral nerve injury. J Neurol Sci. 1989; 91(3): 259-92. [PubMed: 2769297]
28. Clarke D, Richardson P. Peripheral nerve injury. Curr Opin Neurol. 1994; 7(5): 415-421. [PubMed: 7804462]
29. Kubo T, Yamashita T, Yamaguchi A, Hosokawa K, Tohyama M. Analysis of genes induced in peripheral nerve after axotomy using cDNA micro-arrays. J Neurochem. 2002; 82(5):1129-36. [PubMed: 12358760]
30. Zochodne DW, Levy D. Nitric oxide in damage, disease and repair of the peripheral nervous system. Cell MolBiol (Noisy-le-grand). 2005; 51(3): 255-67. [PubMed: 16191393]
31. Lee HM, Lee OH, Kim KJ, Lee BY. Ginsenoside Rgl promotes glucose uptake through activated AMPK pathway in insulin-resistant muscle cells. Phytother Res. 2012 Jul;26(7):1017-22.
32. Kim SJ, Yuan HD, Chung SH. Ginsenoside Rgl suppresses hepatic glucose production via AMP-activated protein kinase in HepG2 cells. Biol Pharm Bull. 2010;33(2):325-8.
33. Wang Y, Kuro-o M, Sun Z. Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway. Aging Cell. 2012 Jun;11(3):410-7.
34. Okada K, Tanaka H, Temporin K, Okamoto M, Kuroda Y, Moritomo H, Murase T, Yoshikawa H. Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol. 2010 Apr;222(2):191-203.
35. Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med. 1999 Jun;38(6):472-5.
36. Jiang M, Zhuge X, Yang Y, Gu X, Ding F. The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model. Neurosci Lett. 2009 May 1;454(3):239-43.
37. Yuan Y, Shen H, Yao J, Hu N, Ding F, Gu X. The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury. Brain Res Bull. 2010 Jan 15;81(1):25-32.