Tributyltin induces oxidative damage, inflammation and apoptosis via disturbance in blood-brain barrier and metal homeostasis in cerebral cortex of rat brain: An in vivo and in vitro study

Toxicology

Volumn 310, Issue , 2013, Pages 39-52

  Mitra, Sumonto ^a,b   Gera, Ruchi ^a   Siddiqui, Waseem A ^b   Khandelwal, Shashi ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

Apoptosis; Inflammation; Neurotoxicity; Oxidative damage; Tributyltin chloride

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM; CALPAIN; CASPASE 3; CASPASE 8; COPPER; CYCLOOXYGENASE 2; DNA; EGTAZIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GLUTATHIONE; GLUTATHIONE DISULFIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; IRON; LIPOCORTIN 5; NEUROFILAMENT PROTEIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SCAVENGER; SYNAPTOPHYSIN; TAU PROTEIN; TRIBUTYLTIN CHLORIDE; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CALCIUM SIGNALING; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIPID PEROXIDATION; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN CLEAVAGE; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; UPREGULATION;

APOPTOSIS; INFLAMMATION; NEUROTOXICITY; OXIDATIVE DAMAGE; TRIBUTYLTIN CHLORIDE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; ASTROCYTES; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; CYTOKINES; ENVIRONMENTAL POLLUTANTS; HOMEOSTASIS; LIPID PEROXIDATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; METALS, HEAVY; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TRIALKYLTIN COMPOUNDS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 84879824094     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.05.011     Document Type: Article

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