Impact of timing and dose of mesenchymal stromal cell therapy in a preclinical model of acute myocardial infarction

Journal of Cardiac Failure

Volumn 19, Issue 5, 2013, Pages 342-353

  Richardson, James D ^a   Bertaso, Angela G ^a   Psaltis, Peter J ^a,b   Frost, Lachlan ^a   Carbone, Angelo ^a   Paton, Sharon ^a   Nelson, Adam J ^a   Wong, Dennis T L ^a   Worthley, Matthew I ^a   Gronthos, Stan ^a   Zannettino, Andrew C W ^a   Worthley, Stephen G ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b MAYO CLINIC   (United States)

Author keywords

cardiac magnetic resonance; hypoxic conditioning; Mesenchymal stem cells; myocardial infarction; optimisation; prospective isolation; repair; timing

Indexed keywords

CARPROFEN; GREEN FLUORESCENT PROTEIN; KETAMINE; NORFLOXACIN;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR PARAMETERS; CELL THERAPY; CONTROLLED STUDY; DENSITY; HEART DISEASE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICULAR DILATATION; HEART MUSCLE FIBROSIS; HISTOLOGY; MALE; MESENCHYMAL STROMA CELL; MESENCHYMAL STROMAL CELL THERAPY; MICROVASCULAR DENSITY; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTOLIC WALL THICKENING;

ANIMALS; ARTERIOLES; DISEASE MODELS, ANIMAL; FIBROSIS; HEART VENTRICLES; MAGNETIC RESONANCE IMAGING, CINE; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; STROKE VOLUME; TIME-TO-TREATMENT; VENTRICULAR FUNCTION, LEFT;

EID: 84879805933     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2013.03.011     Document Type: Article

References (38)

1. M.J. Lipinski, G.G.L. Biondi-Zoccai, A. Abbate, R. Khianey, I. Sheiban, and J. Bartunek Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials J Am Coll Cardiol 50 2007 1761 1767
2. P.J. Psaltis, A.C.W. Zannettino, S.G. Worthley, and S. Gronthos Concise review: mesenchymal stromal cells: potential for cardiovascular repair Stem Cells 26 2008 2201 2210
3. J. Richardson, A. Nelson, A. Zannettino, S. Gronthos, S. Worthley, and P. Psaltis Optimization of the cardiovascular therapeutic properties of mesenchymal stromal/stem cells - taking the next step Stem Cell Rev Rep 2012 Apr 13 [Epub ahead of print]
4. P.J. Psaltis, S. Paton, F. See, A. Arthur, S. Martin, and S. Itescu Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations J Cell Physiol 223 2010 530 540
5. X. Hu, S.P. Yu, J.L. Fraser, Z. Lu, M.E. Ogle, and J.-A. Wang Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis J Thorac Cardiovasc Surg 135 2008 799 808
6. T.P. Martens, F. See, M.D. Schuster, H.P. Sondermeijer, M.M. Hefti, and A. Zannettino Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium Nat Clin Pract Cardiovasc Med 3 Suppl 1 2006 S18 S22
7. R.-K. Li, D.A.G. Mickle, R.D. Weisel, V. Rao, and Z.-Q. Jia Optimal time for cardiomyocyte transplantation to maximize myocardial function after left ventricular injury Ann Thorac Surg 72 2001 1957 1963
8. M.A. Pfeffer, and E. Braunwald Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications Circulation 81 1990 1161 1172
9. J.I. Virag, and C.E. Murry Myofibroblast and endothelial cell proliferation during murine myocardial infarct repair Am J Pathol 163 2003 2433 2440
10. T.I.G. van der Spoel, S.J. Jansen of Lorkeers, P. Agostoni, E. van Belle, M. Gyöngyösi, and J.P.G. Sluijter Human relevance of pre-clinical studies in stem cell therapy: systematic review and meta-analysis of large animal models of ischaemic heart disease Cardiovasc Res 91 2011 649 658
11. J.H. Traverse, T.D. Henry, S.G. Ellis, C.J. Pepine, J.T. Willerson, and D.X. Zhao Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the Latetime randomized trial JAMA 306 2011 2110 2119
12. X. Hu, J. Wang, J. Chen, R. Luo, A. He, and X. Xie Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction Eur J Cardiothorac Surg 31 2007 438 443
13. W. Dai, S.L. Hale, B.J. Martin, J.-Q. Kuang, J.S. Dow, and L.E. Wold Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium Circulation 112 2005 214 223
14. J.A. Dixon, R.C. Gorman, R.E. Stroud, S. Bouges, H. Hirotsugu, and J.H. Gorman 3rd Mesenchymal cell transplantation and myocardial remodeling after myocardial infarction Circulation 120 11 Suppl 2009 S220 S229
15. B. Black Schaffer, C.E. Grinstead 2nd, and J.N. Braunstein Endocardial fibroelastosis of large mammals Circ Res 16 1965 383 390
16. P.J. Psaltis, A. Carbone, A.J. Nelson, D.H. Lau, T. Jantzen, and J. Manavis Reparative effects of allogeneic mesenchymal precursor cells delivered transendocardially in experimental nonischemic cardiomyopathy JACC Cardiovasc Interv 3 2010 974 983
17. M.D. Cerqueira, N.J. Weissman, V. Dilsizian, A.K. Jacobs, and W.K. Laskey Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart Circulation 105 2002 539 542
18. M. Dominici, K. Le Blanc, I. Mueller, I. Slaper-Cortenbach, F. Marini, and D. Krause Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 8 2006 315 317
19. M. Nowosielski, M. Schocke, A. Mayr, K. Pedarnig, G. Klug, and A. Kohler Comparison of wall thickening and ejection fraction by cardiovascular magnetic resonance and echocardiography in acute myocardial infarction J Cardiovasc Magn Reson 11 2009 22
20. A. Armiñán, C. Gandía, J.M. García-Verdugo, E. Lledó, C. Trigueros, and A. Ruiz-Saurí Mesenchymal stem cells provide better results than hematopoietic precursors for the treatment of myocardial infarction J Am Coll Cardiol 55 2010 2244 2253
21. J. Tang, J. Wang, J. Yang, X. Kong, F. Zheng, and L. Guo Mesenchymal stem cells over-expressing SDF-1 promote angiogenesis and improve heart function in experimental myocardial infarction in rats Eur J Cardiothorac Surg 36 2009 644 650
22. G. Ertl, and S. Frantz Healing after myocardial infarction Cardiovasc Res 66 2005 22 32
23. M. Pittenger, A. Mackay, S. Beck, R. Jaiswal, R. Douglas, and J. Mosca Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147
24. J.M. Hare, J.H. Traverse, T.D. Henry, N. Dib, R.K. Strumpf, and S.P. Schulman A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction J Am Coll Cardiol 54 2009 2277 2286
25. F. See, T. Seki, P.J. Psaltis, H.P. Sondermeijer, S. Gronthos, and A.C. Zannettino Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia J Cell Mol Med 15 2011 2117 2129
26. R. Das, H. Jahr, G.J. van Osch, and E. Farrell The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches Tissue Eng Part B Rev 16 2010 159 168
27. M. Gnecchi, H. He, L.G. Melo, N. Noiseaux, F. Morello, and R.A. de Boer Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction Stem Cells 27 2009 971 979
28. F. Dong, J. Harvey, A. Finan, K. Weber, U. Agarwal, and M.S. Penn Myocardial CXCR4 expression is required for mesenchymal stem cell mediated repair following acute myocardial infarction/clinical perspective Circulation 126 2012 314 324
29. S.H. Kim, H.-H. Moon, H.A. Kim, K.-C. Hwang, M. Lee, and D. Choi Hypoxia-inducible vascular endothelial growth factor-engineered mesenchymal stem cells prevent myocardial ischemic injury Mol Ther 19 2011 741 750
30. M. Hou, K.-M. Yang, H. Zhang, W.-Q. Zhu, F.-J. Duan, and H. Wang Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats Int J Cardiol 115 2007 220 228
31. M. Gnecchi, Z. Zhang, A. Ni, and V.J. Dzau Paracrine mechanisms in adult stem cell signaling and therapy Circ Res 103 2008 1204 1219
32. H. Thangarajah, I.N. Vial, E. Chang, S. El-Ftesi, M. Januszyk, and E.I. Chang IFATS collection: adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia Stem Cells 27 2009 266 274
33. M. Zhang, N. Mal, M. Kiedrowski, M. Chacko, A.T. Askari, and Z.B. Popovic SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction FASEB J 21 2007 3197 3207
34. P.J. Psaltis, R.D. Simari, and M. Rodriguez-Porcel Emerging roles for integrated imaging modalities in cardiovascular cell-based therapeutics: a clinical perspective Eur J Nucl Med Mol Imaging 39 2012 165 181
35. J. Huang, Z. Zhang, J. Guo, A. Ni, A. Deb, and L. Zhang Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium Circ Res 106 2010 1753 1762
36. M.M. Bonab, K. Alimoghaddam, F. Talebian, S.H. Ghaffari, A. Ghavamzadeh, and B. Nikbin Aging of mesenchymal stem cell in vitro BMC Cell Biol 7 2006 14
37. V. Schächinger, S. Erbs, A. Elsässer, W. Haberbosch, R. Hambrecht, and H. Hölschermann Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial Eur Heart J 27 2006 2775 2783
38. S. Aggarwal, and M. Pittenger Human mesenchymal stem cells modulate allogeneic immune cell responses Blood 105 2005 1815 1822