Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Li, Guoqing ^a   Liu, Dan ^a   Zhang, Yu ^a   Qian, Yayun ^a   Zhang, Hua ^a   Guo, Shiyu ^b   Sunagawa, Masataka ^b   Hisamitsu, Tadashi ^b   Liu, Yanqing ^a  

^a YANGZHOU UNIVERSITY   (China)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELASTROL; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; FIBROBLAST LIKE SYNOVIOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY INFILTRATE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CELL CYCLE; CELL MOVEMENT; CELL SURVIVAL; COLLAGEN TYPE II; FEMALE; GENE EXPRESSION REGULATION; HUMANS; JOINT CAPSULE; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PRIMARY CELL CULTURE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRITERPENES;

RATTUS;

EID: 84879801389     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068905     Document Type: Article

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