Mutant Ubiquitin Attenuates Interleukin-1β- and Tumor Necrosis Factor-α-Induced Pro-Inflammatory Signaling in Human Astrocytic Cells

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Choi, Kyungsun ^a   Park, Junseong ^a   Lee, Jungsul ^a   Han, Eun Chun ^a   Choi, Chulhee ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UBIQUITIN;

ARTICLE; ASTROCYTE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STABLE EXPRESSION; UBIQUITINATION;

ASTROCYTES; CELL LINE; CHEMOKINES; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MAP KINASE SIGNALING SYSTEM; MUTATION; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN; UBIQUITINATION;

EID: 84879758517     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067891     Document Type: Article

References (38)

1. Mukhopadhyay D, Riezman H, (2007) Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 315: 201-205.
2. Weissman AM, (2001) Themes and variations on ubiquitylation. Nat Rev Mol Cell Biol 2: 169-178.
3. Chen ZJ, Sun LJ, (2009) Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 33: 275-286.
4. Komander D, Rape M, (2012) The ubiquitin code. Annu Rev Biochem 81: 203-229.
5. van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, et al. (1998) Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. Science 279: 242-247.
6. Hol EM, van Leeuwen FW, Fischer DF, (2005) The proteasome in Alzheimer's disease and Parkinson's disease: lessons from ubiquitin B+1. Trends Mol Med 11: 488-495.
7. de Pril R, Fischer DF, van Leeuwen FW, (2006) Conformational diseases: an umbrella for various neurological disorders with an impaired ubiquitin-proteasome system. Neurobiol Aging 27: 515-523.
8. Lindsten K, de Vrij FM, Verhoef LG, Fischer DF, van Leeuwen FW, et al. (2002) Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation. J Cell Biol 157: 417-427.
9. van Tijn P, de Vrij FM, Schuurman KG, Dantuma NP, Fischer DF, et al. (2007) Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease. J Cell Sci 120: 1615-1623.
10. Fischer DF, De Vos RA, Van Dijk R, De Vrij FM, Proper EA, et al. (2003) Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain. Faseb J 17: 2014-2024.
11. de Pril R, Fischer DF, Maat-Schieman ML, Hobo B, de Vos RA, et al. (2004) Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases. Hum Mol Genet 13: 1803-1813.
12. De Vrij FM, Sluijs JA, Gregori L, Fischer DF, Hermens WT, et al. (2001) Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. Faseb J 15: 2680-2688.
13. Fratta P, Engel WK, Van Leeuwen FW, Hol EM, Vattemi G, et al. (2004) Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. Neurology 63: 1114-1117.
14. Olive M, van Leeuwen FW, Janue A, Moreno D, Torrejon-Escribano B, et al. (2008) Expression of mutant ubiquitin (UBB+1) and p62 in myotilinopathies and desminopathies. Neuropathol Appl Neurobiol 34: 76-87.
15. Dong Y, Benveniste EN, (2001) Immune function of astrocytes. Glia 36: 180-190.
16. Ransohoff RM, Brown MA Innate immunity in the central nervous system. J Clin Invest 122: 1164-1171.
17. Jones RW, (2001) Inflammation and Alzheimer's disease. Lancet 358: 436-437.
18. Weninger SC, Yankner BA, (2001) Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat Med 7: 527-528.
19. Owens T, Babcock AA, Millward JM, Toft-Hansen H, (2005) Cytokine and chemokine inter-regulation in the inflamed or injured CNS. Brain Res Brain Res Rev 48: 178-184.
20. Sun L, Chen ZJ, (2004) The novel functions of ubiquitination in signaling. Curr Opin Cell Biol 16: 119-126.
21. Adhikari A, Xu M, Chen ZJ, (2007) Ubiquitin-mediated activation of TAK1 and IKK. Oncogene 26: 3214-3226.
22. Choi K, Lee J, Choi C, (2007) Divergent effect of proteasome inhibition on interleukin-1beta and tumor necrosis factor alpha signaling in human astroglial cells. FEBS Lett 581: 4691-4696.
23. Choi C, Kutsch O, Park JS, Zhou T, Seol DW, et al. (2002) Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) induces caspase-dependent Interleukin-8 expression and apoptosis in human astroglioma cells. Mol Cell Biol 22: 724-736.
24. Bajetto A, Bonavia R, Barbero S, Schettini G, (2002) Characterization of chemokines and their receptors in the central nervous system: physiopathological implications. J Neurochem 82: 1311-1329.
25. Majumder S, Zhou LZ, Ransohoff RM, (1996) Transcriptional regulation of chemokine gene expression in astrocytes. J Neurosci Res 45: 758-769.
26. Karin M, Ben-Neriah Y, (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol 18: 621-663.
27. Yamasaki T, Kawasaki H, Nishina H Diverse Roles of JNK and MKK Pathways in the Brain. J Signal Transduct 2012: 459265.
28. Davis RJ, (2000) Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252.
29. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, et al. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412: 346-351.
30. Tank EM, True HL, (2009) Disease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates. PLoS Genet 5: e1000382.
31. Chadwick L, Gentle L, Strachan J, Layfield R, (2012) Review: unchained maladie- a reassessment of the role of Ubb(+1)-capped polyubiquitin chains in Alzheimer's disease. Neuropathol Appl Neurobiol 38: 118-131.
32. van Tijn P, Dennissen FJ, Gentier RJ, Hobo B, Hermes D, et al. (2012) Mutant ubiquitin decreases amyloid beta plaque formation in a transgenic mouse model of Alzheimer's disease. Neurochem Int 61: 739-748.
33. Xia ZP, Sun L, Chen X, Pineda G, Jiang X, et al. (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461: 114-119.
34. Lee J, Choi K, Choi C, (2010) Delineating role of ubiquitination on nuclear factor-kappa B pathway by a computational modeling approach. Biochem Biophys Res Commun 391: 33-37.
35. Tan Z, Sun X, Hou FS, Oh HW, Hilgenberg LG, et al. (2007) Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Cell Death Differ 14: 1721-1732.
36. Reddy PH, Shirendeb UP, (2012) Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease. Biochim Biophys Acta 1822: 101-110.
37. Shaw JM, Nunnari J, (2002) Mitochondrial dynamics and division in budding yeast. Trends Cell Biol 12: 178-184.
38. Escobar-Henriques M, Anton F, (2012) Mechanistic perspective of mitochondrial fusion: Tubulation vs. fragmentation. Biochim Biophys Acta 1833: 162-175.