Combined Patterns of IGHV Repertoire and Cytogenetic/Molecular Alterations in Monoclonal B Lymphocytosis versus Chronic Lymphocytic Leukemia

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Henriques, Ana ^a,b   Rodríguez Caballero, Arancha ^a   Nieto, Wendy G ^a   Langerak, Anton W ^c   Criado, Ignacio ^a   Lécrevisse, Quentin ^a   González, Marcos ^d   Pais, Maria L ^b   Paiva, Artur ^b   Almeida, Julia ^a   Orfao, Alberto ^a  

^a Centro de Investigacion del Cancer   (Spain)

^b IP   (Portugal)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CELL CLONING; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 13; CHROMOSOME 14; CHROMOSOME 17; CHROMOSOME ANALYSIS; CHROMOSOME DELETION 13; CHROMOSOME DELETION 13Q; CHRONIC LYMPHATIC LEUKEMIA; CLONAL EVOLUTION; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IGHV GENE; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; MOLECULAR GENETICS; MONOCLONAL B CELL LYMPHOCYTOSIS; MUTATIONAL ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; B-LYMPHOCYTES; CELL SIZE; CHROMOSOME ABERRATIONS; CLONE CELLS; FEMALE; GENE REARRANGEMENT; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTE COUNT; LYMPHOCYTOSIS; MALE; MIDDLE AGED; MUTATION; PRINCIPAL COMPONENT ANALYSIS; RECEPTOR, NOTCH1; RECEPTORS, ANTIGEN, B-CELL;

EID: 84879757256     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067751     Document Type: Article

References (40)

1. Rawstron AC, Bennett FL, O'Connor SJ, Kwok M, Fenton JA, et al. (2008) Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med 359: 575-583.
2. Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, et al. (2005) Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 130: 325-332.
3. Scarfo L, Dagklis A, Scielzo C, Fazi C, Ghia P, (2010) CLL-like monoclonal B-cell lymphocytosis: are we all bound to have it? Semin Cancer Biol 20: 384-390.
4. Shanafelt TD, Kay NE, Rabe KG, Call TG, Zent CS, et al. (2009) Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol 27: 3959-3963.
5. Landgren O, Albitar M, Ma W, Abbasi F, Hayes RB, et al. (2009) B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med 360: 659-667.
6. Lanasa MC, Allgood SD, Volkheimer AD, Gockerman JP, Whitesides JF, et al. (2010) Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis. Leukemia 24: 133-140.
7. Scarfò L, Zibellini S, Tedeschi A, Maura F, Neri A, et al. (2012) Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines? Leukemia 26: 1703-1707.
8. Dagklis A, Fazi C, Sala C, Cantarelli V, Scielzo C, et al. (2009) The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood 114: 26-32.
9. Swerdlow SH (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, fourth edition. Lyon, France: International Agency for Research on Cancer. 439p.
10. Nieto WG, Teodosio C, López A, Rodríguez-Caballero A, Romero A, et al. (2010) Primary Health Care Group of Salamanca for the Study of MBL: Non-CLL-like monoclonal B-cell lymphocytosis in the general population: prevalence and phenotypic/genetic characteristics. Cytometry B ClinCytom 78Suppl 1: S24-34.
11. Sánchez ML, Almeida J, Vidriales B, López-Berges MC, García-Marcos MA, et al. (2002) Incidence of phenotypic aberrations in a series of 467 patients with B chronic lymphoproliferative disorders: basis for the design of specific four-color stainings to be used for minimal residual disease investigation. Leukemia 16: 1460-1469.
12. Nieto WG, Almeida J, Romero A, Teodosio C, López A, et al. (2009) Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood 114: 33-37.
13. Kalina T, Flores-Montero J, van der Velden VH, Martin-Ayuso M, Böttcher S, (2012) EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols. Leukemia 26: 1986-2010.
14. Quijano S, López A, Rasillo A, Sayagués JM, Barrena S, et al. (2008) Impact of trisomy 12, del(13q), del(17p), and del(11q) on the immunophenotype, DNA ploidy status, and proliferative rate of leukemic B-cells in chronic lymphocytic leukemia. Cytometry B ClinCytom 74: 139-149.
15. González D, Balanzategui A, García-Sanz R, Gutiérrez N, Seabra C, et al. (2003) Incomplete DJH rearrangements of the IgH gene are frequent in multiple myeloma patients: immunobiological characteristics and clinical implications. Leukemia 17: 1398-1403.
16. van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, et al. (2003) Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17: 2257-2317.
17. Rossi D, Rasi S, Fabbri G, Spina V, Fangazio M, et al. (2012) Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia. Blood 119: 521-529.
18. Costa ES, Pedreira CE, Barrena S, Lecrevisse Q, Flores J, et al. (2010) Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: a step forward in the standardization of clinical cytometry. Leukemia 24: 1927-1933.
19. Rawstron AC (2009) Monoclonal B-cell lymphocytosis. Hematology Am Soc Hematol Educ Program: 430-439.
20. Kostareli E, Smilevska T, Stamatopoulos K, Kouvatsi A, Anagnostopoulos A, (2008) Chronic lymphocytic leukaemia: an immunobiology approach. Srp Arh Celok Lek 136: 319-323.
21. Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, et al. (2005) A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 353: 1793-1801.
22. Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, et al. (2004) Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 101: 1039-1044.
23. Fabbri G, Rasi S, Rossi D, Trifonov V, Khiabanian H, (2011) Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation. J Exp Med 208: 1389-1401.
24. Zenz T, Mertens D, Dohner H, Stilgenbauer S, (2011) Importance of genetics in chronic lymphocytic leukemia. Blood Rev 25: 131-137.
25. Kern W, Bacher U, Haferlach C, Dicker F, Alpermann T, et al. (2012) Monoclonal B-cell lymphocytosis is closely related to chronic lymphocytic leukaemia and may be better classified as early-stage CLL. Br J Haematol doi: 10.1111/j.1365-2141.2011.09010.x. In press.
26. Lanasa MC, Allgood SD, Slager SL, Dave SS, Love C, et al. (2011) Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL. Leukemia 25: 1459-1466.
27. Vardi A, Dagklis A, Scarfò L, Jelinek D, Newton D, et al. (2013) Immunogenetics shows that not all MBL are equal: the larger the clone the more similar to CLL. Blood 2013 Apr17 [Epub ahead of print].
28. Del Giudice I, Rossi D, Chiaretti S, Marinelli M, Tavolaro S, et al. (2012) NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL. Haematologica 97: 437-441.
29. Rawstron AC, Bennett F, Hillmen P, (2007) The biological and clinical relationship between CD5+23+ monoclonal B-cell lymphocytosis and chronic lymphocytic leukaemia. Br J Haematol 139: 724-729.
30. Shanafelt TD, Kay NE, Call TG, Zent CS, Jelinek DF, et al. (2008) MBL or CLL: which classification best categorizes the clinical course of patients with an absolute lymphocyte count >or = 5×10(9) L(-1) but a B-cell lymphocyte count <5×10(9) L(-1)? Leuk Res 32: 1458-1461.
31. Shanafelt TD, Ghia P, Lanasa MC, Landgren O, Rawstron AC, (2010) Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia 24: 512-520.
32. Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, et al. (2012) Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies. Blood 119 (19): 4467-4475.
33. Chu CC, Catera R, Hatzi K, Yan XJ, Zhang L, et al. (2008) Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA. Blood 112: 5122-5129.
34. Martin T, Duffy SF, Carson DA, Kipps TJ, (1992) Evidence for somatic selection of natural autoantibodies. J Exp Med 175: 983-991.
35. Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, et al. (2004) Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 104: 2879-2885.
36. Arcaini L, Zibellini S, Passamonti F, Rattotti S, Lucioni M, et al. (2009) Splenic marginal zone lymphoma: Clinical clustering of immunoglobulin heavy chain repertoires. Blood Cells Mol Dis 42: 286-291.
37. Buhler A, Zenz T, Stilgenbauer S, (2010) Immunoglobulin heavy chain variable gene usage and (super)-antigen drive in chronic lymphocytic leukemia. Clin Cancer Res 16: 373-375.
38. Lenze D, Berg E, Volkmer-Engert R, Weiser AA, Greiner A, (2006) Influence of antigen on the development of MALT lymphoma. Blood 107: 1141-1148.
39. Casabonne D, Almeida J, Nieto W, Romero A, Fernández-Navarro P, et al. (2012) Common infectious agents and monoclonal B-cell lymphocytosis: a cross-sectional epidemiological study among healthy adults. Plos One 7(12): e52808 doi:10.1371/journal.pone.0052808.
40. Almeida J, Nieto WG, Teodosio C, Pedreira CE, López A, et al. (2011) CLL-like B-lymphocytes are systematically present at very low numbers in peripheral blood of healthy adults. Leukemia 25(4): 718-22.