Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL

Leukemia

Volumn 25, Issue 9, 2011, Pages 1459-1466

  Lanasa, M C ^a   Allgood, S D ^a   Slager, S L ^b   Dave, S S ^a   Love, C ^a   Marti, G E ^c   Kay, N E ^b   Hanson, C A ^b   Rabe, K G ^b   Achenbach, S J ^b   Goldin, L R ^d   Camp, N J ^e   Goodman, B K ^a   Vachon, C M ^b   Spector, L G ^f   Rassenti, L Z ^g   Leis, J F ^h   Gockerman, J P ^a   Strom, S S ⁱ   Call, T G ^b   Glenn, M ^e   Cerhan, J R ^b   Levesque, M C ^j   Weinberg, J B ^a,g   Caporaso, N E ^k   more..

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b Mayo Clinic   (United States)

^c CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^h MAYO CLINIC   (United States)

ⁱ UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^j UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^k DURHAM VA MEDICAL CENTER   (United States)

more..

Author keywords

B cell immunology; Chronic lymphocytic leukemia; gene expression profiling; immunophenotype; monoclonal B lymphocytosis

Indexed keywords

ALPHA4 INTEGRIN; B LYMPHOCYTE RECEPTOR; CD20 ANTIGEN; CD38 ANTIGEN; CD5 ANTIGEN; CD79B ANTIGEN; OLIGONUCLEOTIDE; PROTEIN KINASE ZAP 70;

ARTICLE; B LYMPHOCYTE; CELL SURFACE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOGENETICS; DNA MICROARRAY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; IMMUNOPHENOTYPING; LYMPHOCYTOSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

B-LYMPHOCYTES; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; IMMUNOPHENOTYPING; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 80052427597     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.117     Document Type: Article

References (42)

1. Shanafelt TD, Ghia P, Lanasa MC, Landgren O, Rawstron AC. Monoclonal B-cell lymphocytosis (MBL): biology, natural history and clinical management. Leukemia 2010; 24: 512-520.
2. Marti GE, Rawstron AC, Ghia P, Hillmen P, Houlston RS, Kay N et al. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol 2005; 130: 325-332. (Pubitemid 43899581)
3. Shim YK, Middleton DC, Caporaso NE, Rachel JM, Landgren O, Abbasi F et al. Prevalence of monoclonal B-cell lymphocytosis: a systematic review. Cytometry B Clin Cytom 2010; 78 (Suppl 1): S10-S18.
4. Rawstron AC, Green MJ, Kuzmicki A, Kennedy B, Fenton JA, Evans PA et al. Monoclonal B lymphocytes with the characteristics of 'indolent' chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 2002; 100: 635-639. (Pubitemid 34761129)
5. Ghia P, Prato G, Scielzo C, Stella S, Geuna M, Guida G et al. Monoclonal CD5+ and CD5-B-lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood 2004; 103: 2337-2342. (Pubitemid 38326255)
6. Nieto WG, Almeida J, Romero A, Teodosio C, Lopez A, Henriques AF et al. Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach. Blood 2009; 114: 33-37.
7. Landgren O, Albitar M, Ma W, Abbasi F, Hayes RB, Ghia P et al. B-cell clones as early markers for chronic lymphocytic leukemia. N Engl J Med 2009; 360: 659-667.
8. Rawstron AC, Bennett FL, O'Connor SJ, Kwok M, Fenton JA, Plummer M et al. Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia. N Engl J Med 2008; 359: 575-583.
9. Shanafelt TD, Kay NE, Rabe KG, Call TG, Zent CS, Maddocks K et al. Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia. J Clin Oncol 2009; 27: 3959-3963.
10. Lanasa MC, Allgood SD, Volkheimer AD, Gockerman JP, Whitesides JF, Goodman BK et al. Single-cell analysis reveals oligoclonality among 'low-count' monoclonal B-cell lymphocytosis. Leukemia 2010; 24: 133-140.
11. Dagklis A, Fazi C, Sala C, Cantarelli V, Scielzo C, Massacane R et al. The immunoglobulin gene repertoire of low-count chronic lymphocytic leukemia (CLL)-like monoclonal B lymphocytosis is different from CLL: diagnostic implications for clinical monitoring. Blood 2009; 114: 26-32.
12. Goldin LR, Lanasa MC, Slager SL, Cerhan JR, Vachon CM, Strom SS et al. Common occurrence of monoclonal B-cell lymphocytosis among members of high-risk CLL families. Br J Haematol 2010; 151: 152-158.
13. Fraumeni Jr JF, Vogel CL, DeVita VT. Familial chronic lymphocytic leukemia. Ann Intern Med 1969; 71: 279-284.
14. Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M et al. ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003; 348: 1764-1775. (Pubitemid 36514707)
15. Damle RN, Ghiotto F, Valetto A, Albesiano E, Fais F, Yan XJ et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 2002; 99: 4087-4093. (Pubitemid 35332051)
16. Damle RN, Temburni S, Calissano C, Yancopoulos S, Banapour T, Sison C et al. CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood 2007; 110: 3352-3359. (Pubitemid 350106329)
17. Ibrahim S, Keating M, Do KA, O'Brien S, Huh YO, Jilani I et al. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia. Blood 2001; 98: 181-186.
18. Rassenti LZ, Jain S, Keating MJ, Wierda WG, Grever MR, Byrd JC et al. Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood 2008; 112: 1923-1930.
19. Weinberg JB, Volkheimer AD, Chen Y, Beasley BE, Jiang N, Lanasa MC et al. Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia. Am J Hematol 2007; 82: 1063-1070. (Pubitemid 350209847)
20. Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE et al. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 2003; 101: 4944-4951. (Pubitemid 36857758)
21. Dohner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias. Blood 1995; 85: 1580-1589.
22. Dohner H, Stilgenbauer S, James MR, Benner A, Weilguni T, Bentz M et al. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 1997; 89: 2516-2522. (Pubitemid 27143300)
23. Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL et al. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 1998; 102: 1515-1525. (Pubitemid 28492218)
24. Damle RN,Wasil T, Fais F, Ghiotto F,ValettoA, Allen SL et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840-1847. (Pubitemid 29430399)
25. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-1854. (Pubitemid 29430400)
26. Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910-1916. (Pubitemid 32064784)
27. Hamblin TJ, Orchard JA, Ibbotson RE, Davis Z, Thomas PW, Stevenson FK et al. CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease. Blood 2002; 99: 1023-1029. (Pubitemid 34525567)
28. Shanafelt TD, Geyer SM, Bone ND, Tschumper RC, Witzig TE, Nowakowski GS et al. CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potential. Br J Haematol 2008; 140: 537-546. (Pubitemid 351230080)
29. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 1994; 180: 329-339. (Pubitemid 24181081)
30. Klein U, Rajewsky K, Kuppers R. Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med 1998; 188: 1679-1689. (Pubitemid 28516113)
31. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al. Gene set enrichment analysis: a knowledgebased approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545-15550. (Pubitemid 41528093)
32. Efremov DG, Gobessi S, Longo PG. Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells. Autoimmun Rev 2007; 7: 102-108. (Pubitemid 350116720)
33. Baskar S, Kwong KY, Hofer T, Levy JM, Kennedy MG, Lee E et al. Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia. Clin Cancer Res 2008; 14: 396-404. (Pubitemid 351226106)
34. Fukuda T, Chen L, Endo T, Tang L, Lu D, Castro JE et al. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci USA 2008; 105: 3047-3052. (Pubitemid 351723665)
35. Shanafelt TD, Kay NE, Jenkins G, Call TG, Zent CS, Jelinek DF et al. B-cell count and survival: differentiating chronic lymphocytic leukemia from monoclonal B-cell lymphocytosis based on clinical outcome. Blood 2009; 113: 4188-4196.
36. Rawstron AC, Shingles J, de Tute R, Bennett F, Jack AS, Hillmen P. Chronic lymphocytic leukaemia (CLL) and CLL-type monoclonal B-cell lymphocytosis (MBL) show differential expression of molecules involved in lymphoid tissue homing. Cytometry B Clin Cytom 2010; 78 (Suppl 1): S42-S46.
37. Rossi D, Sozzi E, Puma A, De Paoli L, Rasi S, Spina V et al. The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors. Br J Haematol 2009; 146: 64-75.
38. Tam CS, Shanafelt TD, Wierda WG, Abruzzo LV, Van Dyke DL, O'Brien S et al. De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the M. D. Anderson and Mayo Clinic experience. Blood 2009; 114: 957-964.
39. Morice WG, Kurtin PJ, Hodnefield JM, Shanafelt TD, Hoyer JD, Remstein ED et al. Predictive value of blood and bone marrow flow cytometry in B-cell lymphoma classification: comparative analysis of flow cytometry and tissue biopsy in 252 patients. Mayo Clin Proc 2008; 83: 776-785. (Pubitemid 351948691)
40. Goldin LR, Bjorkholm M, Kristinsson SY, Turesson I, Landgren O. Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia. Haematologica 2009; 94: 647-653.
41. Crowther-Swanepoel D, Corre T, Lloyd A, Gaidano G, Olver B, Bennett FL et al. Inherited genetic susceptibility to monoclonal B-cell lymphocytosis. Blood 2010; 116: 5957-5960.
42. Slager SL, Goldin LR, Strom SS, Lanasa MC, Spector LG, Rassenti L et al. Genetic susceptibility variants for chronic lymphocytic leukemia. Cancer Epidemiol Biomarkers Prev 2010; 19: 1098-1102.