Pharmacokinetic and pharmacodynamic studies of poly(amidoamine) dendrimer based simvastatin oral formulations for the treatment of hypercholesterolemia

Molecular Pharmaceutics

Volumn 10, Issue 7, 2013, Pages 2528-2533

  Kulhari, Hitesh ^a   Kulhari, Deep Pooja ^a   Prajapati, Sunil Kumar ^a   Chauhan, Abhay Singh ^b  

^a BUNDELKHAND UNIVERSITY   (India)

^b Department of Pharmaceutical Sciences   (United States)

Author keywords

cholesterol; pharmacodynamic; pharmacokinetic; poly(amidoamine) dendrimers; simvastatin

Indexed keywords

CHOLESTEROL; DENDRIMER; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; POLYAMIDOAMINE; SIMVASTATIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; INFRARED SPECTROSCOPY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL; DENDRIMERS; HYPERCHOLESTEROLEMIA; MALE; POLYAMINES; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 84879731719     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300650y     Document Type: Article

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