Development and analysis of alpha 1-antitrypsin neoglycoproteins: The impact of additional N -glycosylation sites on serum half-life

Molecular Pharmaceutics

Volumn 10, Issue 7, 2013, Pages 2616-2629

  Lusch, Astrid ^a,b,d   Kaup, Matthias ^a   Marx, Uwe ^c   Tauber, Rudolf ^a   Blanchard, Véronique ^a   Berger, Markus ^a  

^a Berlin Buch   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c PROBIOGEN AG   (Germany)

^d BEUTH UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

alpha 1 antitrypsin; clearance; mass spectrometry; N glycan; serum half life

Indexed keywords

RECOMBINANT ALPHA 1 ANTITRYPSIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; EMBRYO; HUMAN; HUMAN CELL; IN VIVO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; SITE DIRECTED MUTAGENESIS;

ALPHA 1-ANTITRYPSIN; ANIMALS; BLOTTING, WESTERN; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; MICE; POLYSACCHARIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84879725035     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400043r     Document Type: Article

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