Structure-activity profiles of complex biantennary glycans with core fucosylation and with/without additional α2,3/α2,6 sialylation: Synthesis of neoglycoproteins and their properties in lectin assays, cell binding, and organ uptake

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 478-491

  Unverzagt, Carlo ^a   André, Sabine ^b   Seifert, Joachim ^a   Kojima, Shuji ^c   Fink, Christian ^d   Srikrishna, Geetha ^e   Freeze, Hudson ^e   Kayser, Klaus ^d   Gabius, Hans Joachim ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d Abteilung Pathologie   (Germany)

^e BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCAN; ISOTHIOCYANIC ACID DERIVATIVE; LECTIN; NEOGLYCOPROTEIN;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DERIVATIZATION; FUCOSYLATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PROTEIN PROTEIN INTERACTION; SIALYLATION; SOLID PHASE EXTRACTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CARBOHYDRATE SEQUENCE; CARCINOMA, EHRLICH TUMOR; CATTLE; DRUG CARRIERS; FUCOSE; GALECTIN 1; GLYCOPROTEINS; HEMAGGLUTININS; HUMANS; IMMUNOGLOBULIN G; LIGANDS; LUNG NEOPLASMS; MICE; MOLECULAR SEQUENCE DATA; N-ACETYLNEURAMINIC ACID; PLANT PREPARATIONS; PLANT PROTEINS; POLYSACCHARIDES; PROTEIN BINDING; SERUM ALBUMIN, BOVINE; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TOXINS, BIOLOGICAL; TUMOR CELLS, CULTURED;

EID: 0037122782     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0110237     Document Type: Article

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