Solid-state photodegradation of bovine somatotropin (bovine growth hormone): Evidence for tryptophan-mediated photooxidation of disulfide bonds

Journal of Pharmaceutical Sciences

Volumn 92, Issue 8, 2003, Pages 1698-1709

  Miller, Brian L ^a,b   Hageman, Michael J ^b   Thamann, Thomas J ^b   Barròn, Lorena B ^a   Schöneich, Christian ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b PFIZER INC   (United States)

Author keywords

Bovine growth hormone; Cystine; Photooxidation; ThiyL radicals; Tryptophan

Indexed keywords

AMINO ACID; CYSTEINE; RADICAL; RECOMBINANT GROWTH HORMONE; RECOMBINANT PROTEIN; THIOL DERIVATIVE; TRYPTOPHAN;

AMINO ACID ANALYSIS; ARTICLE; DISULFIDE BOND; DRUG FORMULATION; FLUORESCENCE SPECTROSCOPY; FOURIER TRANSFORMATION; INFRARED SPECTROSCOPY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PHOTODEGRADATION; PHOTOLYSIS; PHOTOOXIDATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAMAN SPECTROMETRY; REVERSED PHASE LIQUID CHROMATOGRAPHY; SOLID STATE; TANDEM MASS SPECTROMETRY; ULTRAVIOLET SPECTROSCOPY;

EID: 0041709212     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10418     Document Type: Article

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