메뉴 건너뛰기




Volumn 5, Issue 1, 2013, Pages 133-146

New and emerging combination therapies for esophageal cancer

Author keywords

Chemoradiation; Chemotherapy; Molecular targeted therapy

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; GEFITINIB; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IFOSFAMIDE; IRINOTECAN; LAPATINIB; MITOMYCIN; NAVELBINE; NEDAPLATIN; OXALIPLATIN; PACLITAXEL; PANITUMUMAB; RAMUCIRUMAB; SUNITINIB; TRASTUZUMAB; UNINDEXED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

EID: 84879705437     PISSN: None     EISSN: 11791322     Source Type: Journal    
DOI: 10.2147/CMAR.S32199     Document Type: Review
Times cited : (33)

References (112)
  • 1
    • 84879710385 scopus 로고    scopus 로고
    • Ösophagus einschließlich ösophagogastraler Übergang
    • 7th ed. Leipzig, Germany: Springer-Verlag
    • Wittekind C, Meyer HJ. Ösophagus einschließlich ösophagogastraler Übergang [Esophagus including esophagogastric junction]. In: TNM-Klassifkation Maligner Tumoren 2010, 7th ed. Leipzig, Germany: Springer-Verlag. 2010;63-68.
    • (2010) TNM-Klassifkation Maligner Tumoren 2010 , pp. 63-68
    • Wittekind, C.1    Meyer, H.J.2
  • 2
    • 84869044545 scopus 로고    scopus 로고
    • Current treatment options for the management of esophageal cancer
    • Mawhinney MR, Glasgow RE. Current treatment options for the management of esophageal cancer. Cancer Manag Res. 2012;4:367-377.
    • (2012) Cancer Manag Res , vol.4 , pp. 367-377
    • Mawhinney, M.R.1    Glasgow, R.E.2
  • 3
    • 79959572435 scopus 로고    scopus 로고
    • Survival after neo-adjuvant chemotherapy or chemoradiotherapy for resectable esopha-geal carcinoma: An updated meta-analysis
    • Sjoquist KM, Burmeister BH, Smithers BM, et al. Survival after neo-adjuvant chemotherapy or chemoradiotherapy for resectable esopha-geal carcinoma: an updated meta-analysis. Lancet Oncol. 2011;12(7): 681-692.
    • (2011) Lancet Oncol , vol.12 , Issue.7 , pp. 681-692
    • Sjoquist, K.M.1    Burmeister, B.H.2    Smithers, B.M.3
  • 4
    • 84856684523 scopus 로고    scopus 로고
    • A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-FU versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907)
    • Ando N, Kato H, Igaki H, et al. A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-FU versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol. 2012;19(1):68-74.
    • (2012) Ann Surg Oncol , vol.19 , Issue.1 , pp. 68-74
    • Ando, N.1    Kato, H.2    Igaki, H.3
  • 5
    • 33745726677 scopus 로고    scopus 로고
    • Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    • Cunningham D, Allum WH, Stenning S P, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355(1):11-20.
    • (2006) N Engl J Med , vol.355 , Issue.1 , pp. 11-20
    • Cunningham, D.1    Allum, W.H.2    Stenning, S.P.3
  • 6
    • 79955576900 scopus 로고    scopus 로고
    • Perioperative chemotherapy compared with surgery alone for resectable gastresophageal adenocarci-noma: An FNCLCC and FFCD multicenter phase III trial
    • Ychou M, Boige V, Pignon J P, et al. Perioperative chemotherapy compared with surgery alone for resectable gastresophageal adenocarci-noma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol. 2011;29(13):1715-1721.
    • (2011) J Clin Oncol , vol.29 , Issue.13 , pp. 1715-1721
    • Ychou, M.1    Boige, V.2    Pignon, J.P.3
  • 7
    • 84868114897 scopus 로고    scopus 로고
    • Perioperative chemotherapy with docetaxel, cisplatin, and capecitabine (DCX) in gas-troesophageal adenocarcinoma: A phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • Thuss-Patience PC, Hofheinz RD, Arnold D, et al. Perioperative chemotherapy with docetaxel, cisplatin, and capecitabine (DCX) in gas-troesophageal adenocarcinoma: a phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Ann Oncol. 2012;23(11):2827-2834.
    • (2012) Ann Oncol , vol.23 , Issue.11 , pp. 2827-2834
    • Thuss-Patience, P.C.1    Hofheinz, R.D.2    Arnold, D.3
  • 8
    • 84861748963 scopus 로고    scopus 로고
    • Perioperative docetaxel, cisplatin, and 5-FU (DCF) for locally advanced esophageal and gastric adenocarci-noma: A multicenter phase II trial
    • Ferri LE, Ades S, Alcindor T, et al. Perioperative docetaxel, cisplatin, and 5-FU (DCF) for locally advanced esophageal and gastric adenocarci-noma: a multicenter phase II trial. Ann Oncol. 2012;23(6): 1512-1517.
    • (2012) Ann Oncol , vol.23 , Issue.6 , pp. 1512-1517
    • Ferri, L.E.1    Ades, S.2    Alcindor, T.3
  • 9
    • 84864583237 scopus 로고    scopus 로고
    • Prospective phase II study of neoadjuvant therapy with cisplatin, 5-FU, and bevacizumab for locally advanced resectable esophageal cancer
    • Idelevich E, Kashtan H, Klein Y, et al. Prospective phase II study of neoadjuvant therapy with cisplatin, 5-FU, and bevacizumab for locally advanced resectable esophageal cancer. Onkologie. 2012;35(7-8): 427-431.
    • (2012) Onkologie , vol.35 , Issue.7-8 , pp. 427-431
    • Idelevich, E.1    Kashtan, H.2    Klein, Y.3
  • 10
    • 0035818048 scopus 로고    scopus 로고
    • Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
    • Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345(10): 725-730.
    • (2001) N Engl J Med , vol.345 , Issue.10 , pp. 725-730
    • Macdonald, J.S.1    Smalley, S.R.2    Benedetti, J.3
  • 11
    • 84864012541 scopus 로고    scopus 로고
    • Updated analysis of SWOG-directed intergroup study 0116: A phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection
    • Smalley SR, Benedetti JK, Haller DG, et al. Updated analysis of SWOG-directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection. J Clin Oncol. 2012;30(19):2327-2333.
    • (2012) J Clin Oncol , vol.30 , Issue.19 , pp. 2327-2333
    • Smalley, S.R.1    Benedetti, J.K.2    Haller, D.G.3
  • 12
    • 84864344295 scopus 로고    scopus 로고
    • Survival after adjuvant chemoradiotherapy or surgery alone in resectable adenocarcinoma at the gastroesophageal junction
    • Kofoed SC, Muhic A, Baeksgaard L, et al. Survival after adjuvant chemoradiotherapy or surgery alone in resectable adenocarcinoma at the gastroesophageal junction. Scand J Surg. 2012;101(1):26-31.
    • (2012) Scand J Surg , vol.101 , Issue.1 , pp. 26-31
    • Kofoed, S.C.1    Muhic, A.2    Baeksgaard, L.3
  • 13
    • 83355163397 scopus 로고    scopus 로고
    • S0356: A phase II clinical and prospective molecular trial with oxaliplatin, fuoroura-cil, and external-beam radiation therapy before surgery for patients with esophageal adenocarcinoma
    • Leichman L P, Goldman BH, Bohanes PO, et al. S0356: a phase II clinical and prospective molecular trial with oxaliplatin, fuoroura-cil, and external-beam radiation therapy before surgery for patients with esophageal adenocarcinoma. J Clin Oncol. 2011;29(34): 4555-4560.
    • (2011) J Clin Oncol , vol.29 , Issue.34 , pp. 4555-4560
    • Leichman, L.P.1    Goldman, B.H.2    Bohanes, P.O.3
  • 14
    • 84861334363 scopus 로고    scopus 로고
    • Phase 2 trial of induction and concurrent chemoradiotherapy with weekly irinotecan and cisplatin followed by surgery for esophageal cancer
    • Ilson DH, Minsky BD, Ku G Y, et al. Phase 2 trial of induction and concurrent chemoradiotherapy with weekly irinotecan and cisplatin followed by surgery for esophageal cancer. Cancer. 2012;118(11):2820-2827.
    • (2012) Cancer , vol.118 , Issue.11 , pp. 2820-2827
    • Ilson, D.H.1    Minsky, B.D.2    Ku, G.Y.3
  • 15
    • 84874259578 scopus 로고    scopus 로고
    • Neoadjuvant therapy with weekly docetaxel and cisplatin, 5-FU continuous infusion, and concurrent radiotherapy in patients with locally advanced esophageal cancer produced a high percentage of long-lasting pathological complete response: A phase 2 study
    • Pasini F, de Manzoni G, Zanoni A, et al. Neoadjuvant therapy with weekly docetaxel and cisplatin, 5-FU continuous infusion, and concurrent radiotherapy in patients with locally advanced esophageal cancer produced a high percentage of long-lasting pathological complete response: a phase 2 study. Cancer. 2013;119(5):939-945.
    • (2013) Cancer , vol.119 , Issue.5 , pp. 939-945
    • Pasini, F.1    de Manzoni, G.2    Zanoni, A.3
  • 16
    • 84861679981 scopus 로고    scopus 로고
    • Preoperative chemoradiotherapy for esophageal or junctional cancer
    • van Hagen P, Hulshof MC, van Lanschot JJ, et al. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012;366(22):2074-2084.
    • (2012) N Engl J Med , vol.366 , Issue.22 , pp. 2074-2084
    • van Hagen, P.1    Hulshof, M.C.2    van Lanschot, J.J.3
  • 17
    • 75449106396 scopus 로고    scopus 로고
    • Neoadjuvant chemoradio-therapy for resectable esophageal carcinoma: A meta-analysis
    • Jin HL, Zhu H, Ling TS, Zhang HJ, Shi RH. Neoadjuvant chemoradio-therapy for resectable esophageal carcinoma: a meta-analysis. World J Gastroenterol. 2009;15(47):5983-5991.
    • (2009) World J Gastroenterol , vol.15 , Issue.47 , pp. 5983-5991
    • Jin, H.L.1    Zhu, H.2    Ling, T.S.3    Zhang, H.J.4    Shi, R.H.5
  • 18
    • 0027055350 scopus 로고
    • Preoperative radiotherapy prolongs survival in operable esophageal carcinoma: A randomized, multicenter study of preoperative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer
    • Nygaard K, Hagen S, Hansen HS, et al. Preoperative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of preoperative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer. World J Surg. 1992; 16(6):1104-1109.
    • (1992) World J Surg , vol.16 , Issue.6 , pp. 1104-1109
    • Nygaard, K.1    Hagen, S.2    Hansen, H.S.3
  • 19
    • 0027964948 scopus 로고
    • A prospective study of combined therapy in esophageal cancer
    • Apinop C, Puttisak P, Preecha N. A prospective study of combined therapy in esophageal cancer. Hepatogastroenterology. 1994;41(4): 391-393.
    • (1994) Hepatogastroenterology , vol.41 , Issue.4 , pp. 391-393
    • Apinop, C.1    Puttisak, P.2    Preecha, N.3
  • 20
    • 0028265179 scopus 로고
    • A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus
    • Le Prise E, Etienne PL, Meunier B, et al. A randomized study of chemotherapy, radiation therapy, and surgery versus surgery for localized squamous cell carcinoma of the esophagus. Cancer. 1994;73(7): 1779-1784.
    • (1994) Cancer , vol.73 , Issue.7 , pp. 1779-1784
    • Le Prise, E.1    Etienne, P.L.2    Meunier, B.3
  • 22
    • 0030793423 scopus 로고    scopus 로고
    • Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus
    • Bosset JF, Gignoux M, Triboulet J P, et al. Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med. 1997;337(3):161-167.
    • (1997) N Engl J Med , vol.337 , Issue.3 , pp. 161-167
    • Bosset, J.F.1    Gignoux, M.2    Triboulet, J.P.3
  • 23
    • 0035863382 scopus 로고    scopus 로고
    • Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma
    • Urba SG, Orringer MB, Turrisi A, Iannettoni M, Forastiere A, Strawderman M. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol. 2001;19(2):305-313.
    • (2001) J Clin Oncol , vol.19 , Issue.2 , pp. 305-313
    • Urba, S.G.1    Orringer, M.B.2    Turrisi, A.3    Iannettoni, M.4    Forastiere, A.5    Strawderman, M.6
  • 24
    • 3442899114 scopus 로고    scopus 로고
    • A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma
    • Lee JL, Park SI, Kim SB, et al. A single institutional phase III trial of preoperative chemotherapy with hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma. Ann Oncol. 2004;15(6):947-954.
    • (2004) Ann Oncol , vol.15 , Issue.6 , pp. 947-954
    • Lee, J.L.1    Park, S.I.2    Kim, S.B.3
  • 25
    • 24044509153 scopus 로고    scopus 로고
    • Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the esophagus: A randomized-controlled phase III trial
    • Burmeister BH, Smithers BM, Gebski V, et al. Surgery alone versus chemoradiotherapy followed by surgery for resectable cancer of the esophagus: a randomized-controlled phase III trial. Lancet Oncol. 2005;6(9):659-668.
    • (2005) Lancet Oncol , vol.6 , Issue.9 , pp. 659-668
    • Burmeister, B.H.1    Smithers, B.M.2    Gebski, V.3
  • 26
    • 41949119177 scopus 로고    scopus 로고
    • Phase III trial of trimodality therapy with cisplatin, fuorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781
    • Tepper J, Krasna MJ, Niedzwiecki D, et al. Phase III trial of trimodality therapy with cisplatin, fuorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol. 2008;26(7):1086-1092.
    • (2008) J Clin Oncol , vol.26 , Issue.7 , pp. 1086-1092
    • Tepper, J.1    Krasna, M.J.2    Niedzwiecki, D.3
  • 27
    • 21244465591 scopus 로고    scopus 로고
    • A prospective study of combined chemoradiotherapy followed by surgery in the treatment of esophageal carcinoma
    • Chinese. [with English abstract]
    • An FS, Huang JQ, Xie YT, Chen SH, Rong TH. A prospective study of combined chemoradiotherapy followed by surgery in the treatment of esophageal carcinoma. Zhonghua Zhong Liu Za Zhi. 2003;25(4): 376-379. Chinese. [with English abstract].
    • (2003) Zhonghua Zhong Liu Za Zhi , vol.25 , Issue.4 , pp. 376-379
    • An, F.S.1    Huang, J.Q.2    Xie, Y.T.3    Chen, S.H.4    Rong, T.H.5
  • 28
    • 33750431372 scopus 로고    scopus 로고
    • Randomized-controlled study on preoperative chemoradiotherapy followed by surgery versus surgery alone for esophageal squamous cell cancer in a single institution
    • Natsugoe S, Okumura H, Matsumoto M, et al. Randomized-controlled study on preoperative chemoradiotherapy followed by surgery versus surgery alone for esophageal squamous cell cancer in a single institution. Dis Esophagus. 2006;19(6):468-472.
    • (2006) Dis Esophagus , vol.19 , Issue.6 , pp. 468-472
    • Natsugoe, S.1    Okumura, H.2    Matsumoto, M.3
  • 29
    • 77950898018 scopus 로고    scopus 로고
    • Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma
    • Lv J, Cao X F, Zhu B, Ji L, Tao L, Wang DD. Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma. World J Gastroenterol. 2010;16(13):1649-1654.
    • (2010) World J Gastroenterol , vol.16 , Issue.13 , pp. 1649-1654
    • Lv, J.1    Cao, X.F.2    Zhu, B.3    Ji, L.4    Tao, L.5    Wang, D.D.6
  • 30
    • 79952037118 scopus 로고    scopus 로고
    • Surgery alone versus chemoradiotherapy followed by surgery for localized esophageal cancer: Analysis of a randomized-controlled trial FFCD 9901
    • Mariette C, Seitz JF, Maillard E, et al. Surgery alone versus chemoradiotherapy followed by surgery for localized esophageal cancer: analysis of a randomized-controlled trial FFCD 9901. J Clin Oncol. 2010;28(Suppl 15):4005.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15 , pp. 4005
    • Mariette, C.1    Seitz, J.F.2    Maillard, E.3
  • 31
    • 84864390180 scopus 로고    scopus 로고
    • A phase II trial of preoperative concurrent chemotherapy/radiation therapy plus bevacizumab/erlotinib in the treatment of localized esophageal cancer
    • Bendell JC, Meluch A, Peyton J, et al. A phase II trial of preoperative concurrent chemotherapy/radiation therapy plus bevacizumab/erlotinib in the treatment of localized esophageal cancer. Clin Adv Hematol Oncol. 2012;10(7):430-437.
    • (2012) Clin Adv Hematol Oncol , vol.10 , Issue.7 , pp. 430-437
    • Bendell, J.C.1    Meluch, A.2    Peyton, J.3
  • 32
    • 0033526355 scopus 로고    scopus 로고
    • Chemoradiotherapy of locally advanced esophageal cancer: Long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group
    • Cooper JS, Guo MD, Herskovic A, et al. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group. JAMA. 1999;281(17):1623-1627.
    • (1999) JAMA , vol.281 , Issue.17 , pp. 1623-1627
    • Cooper, J.S.1    Guo, M.D.2    Herskovic, A.3
  • 33
    • 20244387586 scopus 로고    scopus 로고
    • Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus
    • Stahl M, Stuschke M, Lehmann N, et al. Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus. J Clin Oncol. 2005;23(10):2310-2317.
    • (2005) J Clin Oncol , vol.23 , Issue.10 , pp. 2310-2317
    • Stahl, M.1    Stuschke, M.2    Lehmann, N.3
  • 34
    • 34247150339 scopus 로고    scopus 로고
    • Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102
    • Bedenne L, et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol. 2007;25:1160-1168.
    • (2007) J Clin Oncol , vol.25 , pp. 1160-1168
    • Bedenne, L.1
  • 35
    • 84871567749 scopus 로고    scopus 로고
    • Long-term survival outcomes after defnitive chemoradiation versus surgery in patients with resectable squamous carcinoma of the esophagus: Results from a randomized-controlled trial
    • Teoh AY, Chiu PW, Yeung WK, Liu SY, Wong SK, Ng EK, et al. Long-term survival outcomes after defnitive chemoradiation versus surgery in patients with resectable squamous carcinoma of the esophagus: results from a randomized-controlled trial. Ann Oncol. 2013;24(1): 165-171.
    • (2013) Ann Oncol , vol.24 , Issue.1 , pp. 165-171
    • Teoh, A.Y.1    Chiu, P.W.2    Yeung, W.K.3    Liu, S.Y.4    Wong, S.K.5    Ng, E.K.6
  • 36
    • 84872332517 scopus 로고    scopus 로고
    • Phase Ill randomized trial of defnitive chemoradiotherapy (CRT) with FOLFOX or cisplatin and fuorouracil in esophageal cancer (EC): Final results of the PRODIGE 5/ACCORD 17 trial
    • Conroy T, Galais M P, Raoul JL, et al. Phase Ill randomized trial of defnitive chemoradiotherapy (CRT) with FOLFOX or cisplatin and fuorouracil in esophageal cancer (EC): Final results of the PRODIGE 5/ACCORD 17 trial. J Clin Oncol. 2012;30.
    • (2012) J Clin Oncol , pp. 30
    • Conroy, T.1    Galais, M.P.2    Raoul, J.L.3
  • 37
    • 84879710742 scopus 로고    scopus 로고
    • SCOPE 1:A phase 11/111 trial of chemoradiotherapy in esophageal cancer plus or minus cetuximab
    • Crosby T, Hurt C, Falk S, et al. SCOPE 1:A phase 11/111 trial of chemoradiotherapy in esophageal cancer plus or minus cetuximab. J Clin Oncol. 2012;30.
    • (2012) J Clin Oncol , pp. 30
    • Crosby, T.1    Hurt, C.2    Falk, S.3
  • 38
    • 84871209087 scopus 로고    scopus 로고
    • A phase II study of concurrent chemoradiotherapy with weekly docetaxel and cisplatin in advanced esophageal cancer
    • Shim HJ, Kim DE, Hwang JE, et al. A phase II study of concurrent chemoradiotherapy with weekly docetaxel and cisplatin in advanced esophageal cancer. Cancer Chemother Pharmacol. 2012;70(5): 683-690.
    • (2012) Cancer Chemother Pharmacol , vol.70 , Issue.5 , pp. 683-690
    • Shim, H.J.1    Kim, D.E.2    Hwang, J.E.3
  • 39
    • 79955485070 scopus 로고    scopus 로고
    • Meta-analysis of neoadjuvant treatment modalities and defnitive nonsurgical therapy for esophageal squamous cell cancer
    • Kranzfelder M, Schuster T, Geinitz H, Friess H, Büchler P. Meta-analysis of neoadjuvant treatment modalities and defnitive nonsurgical therapy for esophageal squamous cell cancer. Br J Surg. 2011;98(6):768-783.
    • (2011) Br J Surg , vol.98 , Issue.6 , pp. 768-783
    • Kranzfelder, M.1    Schuster, T.2    Geinitz, H.3    Friess, H.4    Büchler, P.5
  • 40
    • 79953746057 scopus 로고    scopus 로고
    • VEGF as a predictor for response to defnitive chemoradiotherapy and COX-2 as a prognosticator for survival in esophageal squamous cell carcinoma
    • Yoon MS, Nam TK, Lee JS, et al. VEGF as a predictor for response to defnitive chemoradiotherapy and COX-2 as a prognosticator for survival in esophageal squamous cell carcinoma. J Korean Med Sci. 2011;26(4):513-520.
    • (2011) J Korean Med Sci , vol.26 , Issue.4 , pp. 513-520
    • Yoon, M.S.1    Nam, T.K.2    Lee, J.S.3
  • 41
    • 0030789850 scopus 로고    scopus 로고
    • Randomized phase II study of cisplatin and 5-FU (5-FU) versus cisplatin alone in advanced squamous cell esophageal cancer
    • Bleiberg H, Conroy T, Paillot B, et al. Randomized phase II study of cisplatin and 5-FU (5-FU) versus cisplatin alone in advanced squamous cell esophageal cancer. Eur J Cancer. 1997;33(8):1216-1220.
    • (1997) Eur J Cancer , vol.33 , Issue.8 , pp. 1216-1220
    • Bleiberg, H.1    Conroy, T.2    Paillot, B.3
  • 42
    • 77951888102 scopus 로고    scopus 로고
    • Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fuorouracil in advanced gastric or gastroesophageal adenocarcinoma study: The FLAGS trial
    • Ajani JA, Rodriguez W, Bodoky G, et al. Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fuorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial. J Clin Oncol. 2010;28(9):1547-1553.
    • (2010) J Clin Oncol , vol.28 , Issue.9 , pp. 1547-1553
    • Ajani, J.A.1    Rodriguez, W.2    Bodoky, G.3
  • 43
    • 42149176013 scopus 로고    scopus 로고
    • A phase II study of capecitabine and cisplatin (XP) as frst-line chemotherapy in patients with advanced esophageal squamous cell carcinoma
    • Lee J, Im YH, Cho EY, et al. A phase II study of capecitabine and cisplatin (XP) as frst-line chemotherapy in patients with advanced esophageal squamous cell carcinoma. Cancer Chemother Pharmacol. 2008;62(1):77-84.
    • (2008) Cancer Chemother Pharmacol , vol.62 , Issue.1 , pp. 77-84
    • Lee, J.1    Im, Y.H.2    Cho, E.Y.3
  • 44
    • 23844457288 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin, leucovorin, and fuorouracil in patients with advanced carcinoma of the esophagus
    • Mauer AM, Kraut EH, Krauss SA, et al. Phase II trial of oxaliplatin, leucovorin, and fuorouracil in patients with advanced carcinoma of the esophagus. Ann Oncol. 2005;16(8):1320-1325.
    • (2005) Ann Oncol , vol.16 , Issue.8 , pp. 1320-1325
    • Mauer, A.M.1    Kraut, E.H.2    Krauss, S.A.3
  • 45
    • 34247602680 scopus 로고    scopus 로고
    • First-line treatment with oxaliplatin and capecitabine in patients with advanced or meta-static esophageal cancer: A phase II study
    • van Meerten E, Eskens FA, van Gameren EC, et al. First-line treatment with oxaliplatin and capecitabine in patients with advanced or meta-static esophageal cancer: a phase II study. Br J Cancer. 2007;96(9): 1348-1352.
    • (2007) Br J Cancer , vol.96 , Issue.9 , pp. 1348-1352
    • van Meerten, E.1    Eskens, F.A.2    van Gameren, E.C.3
  • 46
    • 29844455992 scopus 로고    scopus 로고
    • Oxaliplatin and capecit-abine in patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction and gastric cardia: A phase II study from the North Central Cancer Treatment Group
    • Jatoi A, Murphy BR, Foster NR, et al. Oxaliplatin and capecit-abine in patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction and gastric cardia: a phase II study from the North Central Cancer Treatment Group. Ann Oncol. 2006;17(1): 29-34.
    • (2006) Ann Oncol , vol.17 , Issue.1 , pp. 29-34
    • Jatoi, A.1    Murphy, B.R.2    Foster, N.R.3
  • 47
    • 41149154862 scopus 로고    scopus 로고
    • Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: A study of the Arbeitsgemeinschaft Internistische Onkologie
    • Al-Batran SE, Hartmann JT, Probst S, et al. Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. J Clin Oncol. 2008; 26(9):1435-1442.
    • (2008) J Clin Oncol , vol.26 , Issue.9 , pp. 1435-1442
    • Al-Batran, S.E.1    Hartmann, J.T.2    Probst, S.3
  • 48
    • 42449161955 scopus 로고    scopus 로고
    • A phase II trial of paclitaxel and cisplatin in patients with advanced squamous-cell carcinoma of the esophagus
    • Zhang X, Shen L, Li J, Li Y, Li J, Jin M. A phase II trial of paclitaxel and cisplatin in patients with advanced squamous-cell carcinoma of the esophagus. Am J Clin Oncol. 2008;31(1):29-33.
    • (2008) Am J Clin Oncol , vol.31 , Issue.1 , pp. 29-33
    • Zhang, X.1    Shen, L.2    Li, J.3    Li, Y.4    Li, J.5    Jin, M.6
  • 49
    • 0031831196 scopus 로고    scopus 로고
    • Phase II trial of paclitaxel, fuorouracil, and cisplatin in patients with advanced carcinoma of the esophagus
    • llson DH, Ajani J, Shalla K, et al. Phase II trial of paclitaxel, fuorouracil, and cisplatin in patients with advanced carcinoma of the esophagus. J Clin Oncol. 1998;16:1826-1834.
    • (1998) J Clin Oncol , vol.16 , pp. 1826-1834
    • Llson, D.H.1    Ajani, J.2    Shalla, K.3
  • 50
    • 0032887574 scopus 로고    scopus 로고
    • Phase II trial of weekly irinotecan plus cisplatin in advanced esophagea l cancer
    • llson DH, Saltz L, Enzinger P, et al. Phase II trial of weekly irinotecan plus cisplatin in advanced esophagea l cancer. J Clin Oncol. 1999;17: 3270-3275.
    • (1999) J Clin Oncol , vol.17 , pp. 3270-3275
    • Llson, D.H.1    Saltz, L.2    Enzinger, P.3
  • 51
    • 0035985295 scopus 로고    scopus 로고
    • Vinorelbine and cisplatin in metastatic squamous cell carcinoma of the oesophagus: Response, toxicity, quality of life and survival
    • Conroy T, Etienne PL, Adenis A, et al. Vinorelbine and cisplatin in metastatic squamous cell carcinoma of the oesophagus: response, toxicity, quality of life and survival. Ann Oncol. 2002;13:721-729.
    • (2002) Ann Oncol , vol.13 , pp. 721-729
    • Conroy, T.1    Etienne, P.L.2    Adenis, A.3
  • 52
    • 80052253286 scopus 로고    scopus 로고
    • Phase II study of weekly paclitaxel and capecitabine in patients with metastatic or recurrent esophageal squamous cell carcinoma
    • Yun T, Han JY, Lee JS, et al. Phase II study of weekly paclitaxel and capecitabine in patients with metastatic or recurrent esophageal squamous cell carcinoma. BMC Cancer. 2011;11:385.
    • (2011) BMC Cancer , vol.11 , pp. 385
    • Yun, T.1    Han, J.Y.2    Lee, J.S.3
  • 53
    • 33645315211 scopus 로고    scopus 로고
    • Docetaxel and capecitabine in patients with metastatic adenocarcinoma of the stomach and gastroe-sophageal junction: A Phase II study from the North Central Cancer Treatment Group
    • Giordano K F, Jatoi A, Stella PJ, et al. Docetaxel and capecitabine in patients with metastatic adenocarcinoma of the stomach and gastroe-sophageal junction: a Phase II study from the North Central Cancer Treatment Group. Ann Oncol. 2006;17(4):652-656.
    • (2006) Ann Oncol , vol.17 , Issue.4 , pp. 652-656
    • Giordano, K.F.1    Jatoi, A.2    Stella, P.J.3
  • 54
    • 22044455162 scopus 로고    scopus 로고
    • Capecitabine plus docetaxel every 3 weeks in first- and second-line metastatic esophageal cancer: Fnal results of a phase II trial
    • Lorenzen S, Duyster J, Lersch C, et al. Capecitabine plus docetaxel every 3 weeks in first- and second-line metastatic esophageal cancer: fnal results of a phase II trial. Br J Cancer. 2005;92(12): 2129-2133.
    • (2005) Br J Cancer , vol.92 , Issue.12 , pp. 2129-2133
    • Lorenzen, S.1    Duyster, J.2    Lersch, C.3
  • 55
    • 38049047178 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • Cunningham D, Starling N, Rao S, et al. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 2008;358(1): 36-46.
    • (2008) N Engl J Med , vol.358 , Issue.1 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3
  • 56
    • 24944465318 scopus 로고    scopus 로고
    • Phase II multi-institutional randomized trial of docetaxel plus cisplatin with or without fuorou-racil in patients with untreated, advanced gastric, or gastroesophageal adenocarcinoma
    • Ajani JA, Fodor MB, Tjulandin SA, et al. Phase II multi-institutional randomized trial of docetaxel plus cisplatin with or without fuorou-racil in patients with untreated, advanced gastric, or gastroesophageal adenocarcinoma. J Clin Oncol. 2005;23(24):5660-5667.
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5660-5667
    • Ajani, J.A.1    Fodor, M.B.2    Tjulandin, S.A.3
  • 57
    • 34848927813 scopus 로고    scopus 로고
    • Split-dose docetaxel, cisplatin, and leucovorin/fuorouracil as frst-line therapy in advanced gastric cancer and adenocarcinoma of the gastroesophageal junction: Results of a phase II trial
    • Lorenzen S, Hentrich M, Haberl C, et al. Split-dose docetaxel, cisplatin, and leucovorin/fuorouracil as frst-line therapy in advanced gastric cancer and adenocarcinoma of the gastroesophageal junction: results of a phase II trial. Ann Oncol. 2007;18(10):1673-1679.
    • (2007) Ann Oncol , vol.18 , Issue.10 , pp. 1673-1679
    • Lorenzen, S.1    Hentrich, M.2    Haberl, C.3
  • 58
    • 34548843674 scopus 로고    scopus 로고
    • Docetaxel, capecitabine, and carboplatin in metastatic esophagogastric cancer: A phase II study
    • Evans D, Miner T, Iannitti D, et al. Docetaxel, capecitabine, and carboplatin in metastatic esophagogastric cancer: a phase II study. Cancer Invest. 2007;25(6):445-448.
    • (2007) Cancer Invest , vol.25 , Issue.6 , pp. 445-448
    • Evans, D.1    Miner, T.2    Iannitti, D.3
  • 59
    • 76349088039 scopus 로고    scopus 로고
    • Randomized, noncom-parative phase II study of weekly docetaxel with cisplatin and 5-FU or with capecitabine in esophagogastric cancer: The AGITG ATTAX trial
    • Tebbutt NC, Cummins MM, Sourjina T, et al. Randomized, noncom-parative phase II study of weekly docetaxel with cisplatin and 5-FU or with capecitabine in esophagogastric cancer: the AGITG ATTAX trial. Br J Cancer. 2010;102(3):475-481.
    • (2010) Br J Cancer , vol.102 , Issue.3 , pp. 475-481
    • Tebbutt, N.C.1    Cummins, M.M.2    Sourjina, T.3
  • 60
    • 84871119467 scopus 로고    scopus 로고
    • A phase II study of biweekly paclitaxel and cisplatin chemotherapy for recurrent or metastatic esophageal squamous cell carcinoma: ERCC1 expression predicts response to chemotherapy
    • Huang J, Zhou Y, Zhang H, et al. A phase II study of biweekly paclitaxel and cisplatin chemotherapy for recurrent or metastatic esophageal squamous cell carcinoma: ERCC1 expression predicts response to chemotherapy. Med Oncol. 2013;30:343.
    • (2013) Med Oncol , vol.30 , pp. 343
    • Huang, J.1    Zhou, Y.2    Zhang, H.3
  • 61
    • 0028023741 scopus 로고
    • Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic fndings and DNA amplification
    • Itakura Y, Sasano H, Shiga C, et al. Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic fndings and DNA amplification. Cancer. 1994;74(3):795-804.
    • (1994) Cancer , vol.74 , Issue.3 , pp. 795-804
    • Itakura, Y.1    Sasano, H.2    Shiga, C.3
  • 62
    • 0029974391 scopus 로고    scopus 로고
    • Further evidence for prognostic significance of epidermal growth factor receptor gene amplification in patients with esophageal squamous cell carcinoma
    • Kitagawa Y, Ueda M, Ando N, et al. Further evidence for prognostic significance of epidermal growth factor receptor gene amplification in patients with esophageal squamous cell carcinoma. Clin Cancer Res. 1996;2(5):909-914.
    • (1996) Clin Cancer Res , vol.2 , Issue.5 , pp. 909-914
    • Kitagawa, Y.1    Ueda, M.2    Ando, N.3
  • 63
    • 23044479392 scopus 로고    scopus 로고
    • Diffuse EGFR staining is associated with reduced overall survival in locally advanced esophageal squamous cell cancer
    • Gibault L, Metges J P, Conan-Charlet V, et al. Diffuse EGFR staining is associated with reduced overall survival in locally advanced esophageal squamous cell cancer. Br J Cancer. 2005;93(1):107-115.
    • (2005) Br J Cancer , vol.93 , Issue.1 , pp. 107-115
    • Gibault, L.1    Metges, J.P.2    Conan-Charlet, V.3
  • 64
    • 2342437556 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression correlates with histologic grade in resected esopha-geal adenocarcinoma
    • Wilkinson N W, Black JD, Roukhadze E, et al. Epidermal growth factor receptor expression correlates with histologic grade in resected esopha-geal adenocarcinoma. J Gastrointest Surg. 2004;8(4):448-453.
    • (2004) J Gastrointest Surg , vol.8 , Issue.4 , pp. 448-453
    • Wilkinson, N.W.1    Black, J.D.2    Roukhadze, E.3
  • 65
    • 70349937924 scopus 로고    scopus 로고
    • Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (DOCETUX study)
    • Pinto C, Di Fabio F, Barone C, et al. Phase II study of cetuximab in combination with cisplatin and docetaxel in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (DOCETUX study). Br J Cancer. 2009;101(8):1261-1268.
    • (2009) Br J Cancer , vol.101 , Issue.8 , pp. 1261-1268
    • Pinto, C.1    Di Fabio, F.2    Barone, C.3
  • 66
    • 79957864676 scopus 로고    scopus 로고
    • Cetuximab with irinotecan, folinic acid, and 5-FU as frst-line treatment in advanced gastroesopha-geal cancer: A prospective multicenter biomarker-oriented phase II study
    • Moehler M, Mueller A, Trarbach T, et al. Cetuximab with irinotecan, folinic acid, and 5-FU as frst-line treatment in advanced gastroesopha-geal cancer: a prospective multicenter biomarker-oriented phase II study. Ann Oncol. 2011;22(6):1358-1366.
    • (2011) Ann Oncol , vol.22 , Issue.6 , pp. 1358-1366
    • Moehler, M.1    Mueller, A.2    Trarbach, T.3
  • 67
    • 33847663871 scopus 로고    scopus 로고
    • Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)
    • Pinto C, Di Fabio F, Siena S, et al. Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study). Ann Oncol. 2007;18(3):510-517.
    • (2007) Ann Oncol , vol.18 , Issue.3 , pp. 510-517
    • Pinto, C.1    Di Fabio, F.2    Siena, S.3
  • 68
    • 76349109904 scopus 로고    scopus 로고
    • Cetuximab plus oxaliplatin/ leucovorin/5-FU in frst-line metastatic gastric cancer: A phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)
    • Lordick F, Luber B, Lorenzen S, et al. Cetuximab plus oxaliplatin/ leucovorin/5-FU in frst-line metastatic gastric cancer: a phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO). Br J Cancer. 2010;102(3):500-505.
    • (2010) Br J Cancer , vol.102 , Issue.3 , pp. 500-505
    • Lordick, F.1    Luber, B.2    Lorenzen, S.3
  • 69
    • 70349641356 scopus 로고    scopus 로고
    • Cetuximab plus cisplatin-5-FU versus cisplatin-5-FU alone in frst-line metastatic squamous cell carcinoma of the esophagus: A randomized phase II study of the Arbeitsgemeinschaft Internistische Onkologie
    • Lorenzen S, Schuster T, Porschen R, et al. Cetuximab plus cisplatin-5-FU versus cisplatin-5-FU alone in frst-line metastatic squamous cell carcinoma of the esophagus: a randomized phase II study of the Arbeitsgemeinschaft Internistische Onkologie. Ann Oncol. 2009;20(10):1667-1673.
    • (2009) Ann Oncol , vol.20 , Issue.10 , pp. 1667-1673
    • Lorenzen, S.1    Schuster, T.2    Porschen, R.3
  • 70
    • 77957552916 scopus 로고    scopus 로고
    • Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: Dose-fnding study for the prospective multicenter, randomized, phase II/III REAL-3 trial
    • Okines A F, Ashley SE, Cunningham D, et al. Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for advanced esophagogastric cancer: dose-fnding study for the prospective multicenter, randomized, phase II/III REAL-3 trial. J Clin Oncol. 2010;28(25):3945-3950.
    • (2010) J Clin Oncol , vol.28 , Issue.25 , pp. 3945-3950
    • Okines, A.F.1    Ashley, S.E.2    Cunningham, D.3
  • 71
    • 84868295867 scopus 로고    scopus 로고
    • A randomized multicenter trial of epirubicin, oxaliplatin, and capecitabine (EOC) plus panitumumab in advanced esophagogastric cancer (REAL3)
    • Waddell TS, Chau I, Barbachano Y, et al. A randomized multicenter trial of epirubicin, oxaliplatin, and capecitabine (EOC) plus panitumumab in advanced esophagogastric cancer (REAL3). J Clin Oncol. 2012;30.
    • (2012) J Clin Oncol , pp. 30
    • Waddell, T.S.1    Chau, I.2    Barbachano, Y.3
  • 72
    • 80052439302 scopus 로고    scopus 로고
    • Phase II trial of modifed FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the esophagus and gastroesophageal junction
    • Wainberg ZA, Lin LS, DiCarlo B, et al. Phase II trial of modifed FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the esophagus and gastroesophageal junction. Br J Cancer. 2011;105(6):760-765.
    • (2011) Br J Cancer , vol.105 , Issue.6 , pp. 760-765
    • Wainberg, Z.A.1    Lin, L.S.2    Dicarlo, B.3
  • 73
    • 0027294912 scopus 로고
    • Amplification and over-expression of the EGFR and erbB-2 genes in human esophageal adenocarcinomas
    • al-Kasspooles M, Moore JH, Orringer MB, Beer DG. Amplification and over-expression of the EGFR and erbB-2 genes in human esophageal adenocarcinomas. Int J Cancer. 1993;54(2):213-219.
    • (1993) Int J Cancer , vol.54 , Issue.2 , pp. 213-219
    • Al-Kasspooles, M.1    Moore, J.H.2    Orringer, M.B.3    Beer, D.G.4
  • 74
    • 0034929997 scopus 로고    scopus 로고
    • The HER-2/neu oncogene in tumors of the gastrointestinal tract
    • Ross JS, McKenna BJ. The HER-2/neu oncogene in tumors of the gastrointestinal tract. Cancer Invest. 2001;19(5):554-568.
    • (2001) Cancer Invest , vol.19 , Issue.5 , pp. 554-568
    • Ross, J.S.1    McKenna, B.J.2
  • 75
    • 77956262693 scopus 로고    scopus 로고
    • Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastroesophageal junction cancer (ToGA): A Phase 3, open-label, randomized-controlled trial
    • Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastroesophageal junction cancer (ToGA): a Phase 3, open-label, randomized-controlled trial. Lancet. 2010;376(9742):687-697.
    • (2010) Lancet , vol.376 , Issue.9742 , pp. 687-697
    • Bang, Y.J.1    van Cutsem, E.2    Feyereislova, A.3
  • 76
    • 84862250597 scopus 로고    scopus 로고
    • Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplifed solid tumors
    • Galsky MD, Vo n Hoff DD, Neubauer M, et al. Target-specific, histology-independent, randomized discontinuation study of lapatinib in patients with HER2-amplifed solid tumors. Invest New Drugs. 2012;30(2):695-701.
    • (2012) Invest New Drugs , vol.30 , Issue.2 , pp. 695-701
    • Galsky, M.D.1    Von Hoff, D.D.2    Neubauer, M.3
  • 77
    • 0031024216 scopus 로고    scopus 로고
    • Vascular endothe-lial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression
    • Inoue K, Ozeki Y, Suganuma T, Sugiura Y, Tanaka S. Vascular endothe-lial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression. Cancer. 1997;79(2):206-213.
    • (1997) Cancer , vol.79 , Issue.2 , pp. 206-213
    • Inoue, K.1    Ozeki, Y.2    Suganuma, T.3    Sugiura, Y.4    Tanaka, S.5
  • 78
    • 0031712037 scopus 로고    scopus 로고
    • Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas
    • Kitadai Y, Haruma K, Tokutomi T, et al. Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas. Clin Cancer Res. 1998;4(9):2195-2200.
    • (1998) Clin Cancer Res , vol.4 , Issue.9 , pp. 2195-2200
    • Kitadai, Y.1    Haruma, K.2    Tokutomi, T.3
  • 79
    • 3843150503 scopus 로고    scopus 로고
    • Vascular endothe-lial growth factor in esophageal cancer
    • Kleespies A, Guba M, Jauch K W, Bruns CJ, et al. Vascular endothe-lial growth factor in esophageal cancer. J Surg Oncol. 2004;87(2): 95-104.
    • (2004) J Surg Oncol , vol.87 , Issue.2 , pp. 95-104
    • Kleespies, A.1    Guba, M.2    Jauch, K.W.3    Bruns, C.J.4
  • 80
    • 0034103553 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus
    • Shih CH, Ozawa S, Ando N, Ueda M, Kitajima M. Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus. Clin Cancer Res. 2000;6(3):1161-1168.
    • (2000) Clin Cancer Res , vol.6 , Issue.3 , pp. 1161-1168
    • Shih, C.H.1    Ozawa, S.2    Ando, N.3    Ueda, M.4    Kitajima, M.5
  • 81
    • 33846629672 scopus 로고    scopus 로고
    • Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma
    • Shah MA, Ramanathan RK, Ilson DH, et al. Multicenter phase II study of irinotecan, cisplatin, and bevacizumab in patients with metastatic gastric or gastroesophageal junction adenocarcinoma. J Clin Oncol. 2006;24(33):5201-5206.
    • (2006) J Clin Oncol , vol.24 , Issue.33 , pp. 5201-5206
    • Shah, M.A.1    Ramanathan, R.K.2    Ilson, D.H.3
  • 82
    • 77957160694 scopus 로고    scopus 로고
    • A phase II study of bevacizumab, oxaliplatin, and docetaxel in locally advanced and metastatic gastric and gastroesophageal junction cancers
    • El-Rayes B F, Zalupski M, Bekai-Saab T, et al. A phase II study of bevacizumab, oxaliplatin, and docetaxel in locally advanced and metastatic gastric and gastroesophageal junction cancers. Ann Oncol. 2009;21(10):1999-2004.
    • (2009) Ann Oncol , vol.21 , Issue.10 , pp. 1999-2004
    • El-Rayes, B.F.1    Zalupski, M.2    Bekai-Saab, T.3
  • 83
    • 77958495206 scopus 로고    scopus 로고
    • AVAGAST: A randomized, double-blind, placebo controlled, phase Ill study of frst-line capecitabine and cisplatin plus bevacizumab or placebo in patients with advanced gastric cancer (AGC)
    • Kang Y, Ohtsu A, Van Cutsem E, et al. AVAGAST: A randomized, double-blind, placebo controlled, phase Ill study of frst-line capecitabine and cisplatin plus bevacizumab or placebo in patients with advanced gastric cancer (AGC). J Clin Oncol. 2010;28:18s.
    • (2010) J Clin Oncol , vol.18 s , pp. 28
    • Kang, Y.1    Ohtsu, A.2    van Cutsem, E.3
  • 84
    • 82955241985 scopus 로고    scopus 로고
    • Phase II study of sunitinib as second-line treatment for advanced gastric cancer
    • Bang YJ, Kang YK, Kang WK, et al. Phase II study of sunitinib as second-line treatment for advanced gastric cancer. Invest New Drugs. 2011;29(6):1449-1458.
    • (2011) Invest New Drugs , vol.29 , Issue.6 , pp. 1449-1458
    • Bang, Y.J.1    Kang, Y.K.2    Kang, W.K.3
  • 85
    • 77954574658 scopus 로고    scopus 로고
    • Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203
    • Sun W, Powell M, O'Dwyer PJ, Catalano P, Ansari RH, Benson AB 3rd. Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. J Clin Oncol. 2010; 28(18):2947-2951.
    • (2010) J Clin Oncol , vol.28 , Issue.18 , pp. 2947-2951
    • Sun, W.1    Powell, M.2    O'Dwyer, P.J.3    Catalano, P.4    Ansari, R.H.5    Benson, A.B.6
  • 86
    • 49749093093 scopus 로고    scopus 로고
    • Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer
    • Ku GY, Ilson DH, Schwartz LH, et al. Phase II trial of sequential paclitaxel and 1 h infusion of bryostatin-1 in patients with advanced esophageal cancer. Cancer Chemother Pharmacol. 2008;62(5): 875-880.
    • (2008) Cancer Chemother Pharmacol , vol.62 , Issue.5 , pp. 875-880
    • Ku, G.Y.1    Ilson, D.H.2    Schwartz, L.H.3
  • 87
    • 33646501280 scopus 로고    scopus 로고
    • A multicenter phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric, or gastroesophageal junction adenocarcinoma
    • Ajani JA, Jiang Y, Faust J, et al. A multicenter phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric, or gastroesophageal junction adenocarcinoma. Invest New Drugs. 2006;24(4):353-357.
    • (2006) Invest New Drugs , vol.24 , Issue.4 , pp. 353-357
    • Ajani, J.A.1    Jiang, Y.2    Faust, J.3
  • 88
    • 9044224771 scopus 로고    scopus 로고
    • Phase II trial of vinorelbine in metastatic squamous cell esophageal carcinoma
    • European Organization for Research and Treatment of Cancer Gastrointestinal Treat Cancer Cooperative Group
    • Conroy T, Etienne PL, Adenis A, et al. Phase II trial of vinorelbine in metastatic squamous cell esophageal carcinoma. European Organization for Research and Treatment of Cancer Gastrointestinal Treat Cancer Cooperative Group. J Clin Oncol. 1996;14(1):164-170.
    • (1996) J Clin Oncol , vol.14 , Issue.1 , pp. 164-170
    • Conroy, T.1    Etienne, P.L.2    Adenis, A.3
  • 89
    • 0036203194 scopus 로고    scopus 로고
    • Phase II trial of docetaxel chemotherapy in patients with incurable adenocarcinoma of the esophagus
    • Heath EI, Urba S, Marshall J, Piantadosi S, Forastiere AA. Phase II trial of docetaxel chemotherapy in patients with incurable adenocarcinoma of the esophagus. Invest New Drugs. 2002;20(1):95-99.
    • (2002) Invest New Drugs , vol.20 , Issue.1 , pp. 95-99
    • Heath, E.I.1    Urba, S.2    Marshall, J.3    Piantadosi, S.4    Forastiere, A.A.5
  • 90
    • 3442902880 scopus 로고    scopus 로고
    • A phase II study of single-agent docetaxel in patients with metastatic esophageal cancer
    • Muro K, Hamaguchi T, Ohtsu A, et al. A phase II study of single-agent docetaxel in patients with metastatic esophageal cancer. Ann Oncol. 2004;15(6):955-959.
    • (2004) Ann Oncol , vol.15 , Issue.6 , pp. 955-959
    • Muro, K.1    Hamaguchi, T.2    Ohtsu, A.3
  • 91
    • 0141676699 scopus 로고    scopus 로고
    • Phase II trial of 96-hour paclitaxel in previously treated patients with advanced esopha-geal cancer
    • Anderson SE, O'Reilly EM, Kelsen D P, Ilson DH. Phase II trial of 96-hour paclitaxel in previously treated patients with advanced esopha-geal cancer. Cancer Invest. 2003;21(4):512-516.
    • (2003) Cancer Invest , vol.21 , Issue.4 , pp. 512-516
    • Anderson, S.E.1    O'Reilly, E.M.2    Kelsen, D.P.3    Ilson, D.H.4
  • 93
    • 84877592384 scopus 로고    scopus 로고
    • Cougar-02: A randomized phase Ill study of docetaxel versus active symptom control in advanced esophagogastric adenocarcinoma
    • Ford H, Marshall A, Wadsley J, et al. Cougar-02: A randomized phase Ill study of docetaxel versus active symptom control in advanced esophagogastric adenocarcinoma. J Clin Oncol. 2012;30.
    • (2012) J Clin Oncol , pp. 30
    • Ford, H.1    Marshall, A.2    Wadsley, J.3
  • 94
    • 0041733716 scopus 로고    scopus 로고
    • Phase II trial of irinotecan plus docetaxel in cisplatin-pretreated relapsed or refractory esophageal cancer
    • Lordick F, von Schilling C, Bernhard H, Hennig M, Bredenkamp R, Peschel C. Phase II trial of irinotecan plus docetaxel in cisplatin-pretreated relapsed or refractory esophageal cancer. Br J Cancer. 2003;89(4):630-633.
    • (2003) Br J Cancer , vol.89 , Issue.4 , pp. 630-633
    • Lordick, F.1    von Schilling, C.2    Bernhard, H.3    Hennig, M.4    Bredenkamp, R.5    Peschel, C.6
  • 95
    • 67650388521 scopus 로고    scopus 로고
    • Phase II trial of docetaxel-irinotecan combination in advanced esophageal cancer
    • Burtness B, Gibson M, Egleston B, et al. Phase II trial of docetaxel-irinotecan combination in advanced esophageal cancer. Ann Oncol. 2009;20(7):1242-1248.
    • (2009) Ann Oncol , vol.20 , Issue.7 , pp. 1242-1248
    • Burtness, B.1    Gibson, M.2    Egleston, B.3
  • 96
    • 78650034169 scopus 로고    scopus 로고
    • Phase II study of docetaxel and cisplatin chemotherapy in 5-FU/cisplatin pretreated esophageal cancer
    • Shim HJ, Cho SH, Hwang JE, et al. Phase II study of docetaxel and cisplatin chemotherapy in 5-FU/cisplatin pretreated esophageal cancer. Am J Clin Oncol. 2010;33(6):624-628.
    • (2010) Am J Clin Oncol , vol.33 , Issue.6 , pp. 624-628
    • Shim, H.J.1    Cho, S.H.2    Hwang, J.E.3
  • 97
    • 33845749675 scopus 로고    scopus 로고
    • Dose escalation study of doc-etaxel and nedaplatin in patients with relapsed or refractory squamous cell carcinoma of the esophagus pretreated using cisplatin, 5-FU, and radiation
    • Yoshioka T, Sakayori M, Kato S, et al. Dose escalation study of doc-etaxel and nedaplatin in patients with relapsed or refractory squamous cell carcinoma of the esophagus pretreated using cisplatin, 5-FU, and radiation. Int J Clin Oncol. 2006;11(6):454-460.
    • (2006) Int J Clin Oncol , vol.11 , Issue.6 , pp. 454-460
    • Yoshioka, T.1    Sakayori, M.2    Kato, S.3
  • 98
    • 57049166512 scopus 로고    scopus 로고
    • A pilot trial of docetaxel and nedaplatin in cisplatin-pretreated relapsed or refractory esophageal squamous cell cancer
    • Nakajima Y, Suzuki T, Haruki S, et al. A pilot trial of docetaxel and nedaplatin in cisplatin-pretreated relapsed or refractory esophageal squamous cell cancer. Hepatogastroenterology. 2008;55(86-87): 1631-1635.
    • (2008) Hepatogastroenterology , vol.55 , Issue.86-87 , pp. 1631-1635
    • Nakajima, Y.1    Suzuki, T.2    Haruki, S.3
  • 99
    • 68349093747 scopus 로고    scopus 로고
    • Second-line combination chemotherapy with docetaxel and nedaplatin for Cisplatin-pretreated refractory metastatic/recurrent esophageal squamous cell carcinoma
    • Jin J, Xu X, Wang F, et al. Second-line combination chemotherapy with docetaxel and nedaplatin for Cisplatin-pretreated refractory metastatic/recurrent esophageal squamous cell carcinoma. J Thorac Oncol. 2009;4(8):1017-1021.
    • (2009) J Thorac Oncol , vol.4 , Issue.8 , pp. 1017-1021
    • Jin, J.1    Xu, X.2    Wang, F.3
  • 100
    • 33750464061 scopus 로고    scopus 로고
    • Combination chemotherapy with docetaxel and nedaplatin for recurrent esophageal cancer in an outpatient setting
    • Osaka Y, Takagi Y, Hoshino S, Tachibana S, Tsuchida A, Aoki T. Combination chemotherapy with docetaxel and nedaplatin for recurrent esophageal cancer in an outpatient setting. Dis Esophagus. 2006; 19(6):473-476.
    • (2006) Dis Esophagus , vol.19 , Issue.6 , pp. 473-476
    • Osaka, Y.1    Takagi, Y.2    Hoshino, S.3    Tachibana, S.4    Tsuchida, A.5    Aoki, T.6
  • 101
    • 36049038526 scopus 로고    scopus 로고
    • Second-line combination chemotherapy with docetaxel for cisplatin-pretreated refractory metastatic esophageal cancer: A preliminary report of initial experience
    • Tanaka T, Fujita H, Sueyoshi S, et al. Second-line combination chemotherapy with docetaxel for cisplatin-pretreated refractory metastatic esophageal cancer: a preliminary report of initial experience. Chemotherapy. 2007;53:449-453.
    • (2007) Chemotherapy , vol.53 , pp. 449-453
    • Tanaka, T.1    Fujita, H.2    Sueyoshi, S.3
  • 102
    • 33847001317 scopus 로고    scopus 로고
    • Evaluation of docetaxel, CDDP, and 5-FU combined therapy as second-line chemotherapy for esophagus cancer
    • Japanese [with English abstract]
    • Minamide J, Aoyama N, Takada K, Oota Y. Evaluation of docetaxel, CDDP, and 5-FU combined therapy as second-line chemotherapy for esophagus cancer. Gan To Kagaku Ryoho. 2007;34(1):49-52. Japanese [with English abstract].
    • (2007) Gan to Kagaku Ryoho , vol.34 , Issue.1 , pp. 49-52
    • Minamide, J.1    Aoyama, N.2    Takada, K.3    Oota, Y.4
  • 103
    • 45849138954 scopus 로고    scopus 로고
    • Salvage chemotherapy with mitomycin C, ifosfamide, and cisplatin (MIC) for previously treated metastatic or recurrent esophageal squamous cell carcinoma
    • Park BB, Im YH, Hwang IG, et al. Salvage chemotherapy with mitomycin C, ifosfamide, and cisplatin (MIC) for previously treated metastatic or recurrent esophageal squamous cell carcinoma. Invest New Drugs. 2008;26(4):387-392.
    • (2008) Invest New Drugs , vol.26 , Issue.4 , pp. 387-392
    • Park, B.B.1    Im, Y.H.2    Hwang, I.G.3
  • 104
    • 79957834501 scopus 로고    scopus 로고
    • A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma
    • Chan JA, Blaszkowsky LS, Enzinger PC, et al. A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma. Ann Oncol. 2011;22(6):1367-1373.
    • (2011) Ann Oncol , vol.22 , Issue.6 , pp. 1367-1373
    • Chan, J.A.1    Blaszkowsky, L.S.2    Enzinger, P.C.3
  • 105
    • 77956267602 scopus 로고    scopus 로고
    • Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: A phase II Southwest Oncology Group Study (S0415)
    • Gold PJ, Goldman B, Iqbal S, et al. Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415). J Thorac Oncol. 2010; 5(9):1472-1476.
    • (2010) J Thorac Oncol , vol.5 , Issue.9 , pp. 1472-1476
    • Gold, P.J.1    Goldman, B.2    Iqbal, S.3
  • 106
    • 80053916746 scopus 로고    scopus 로고
    • Biweekly cetuximab and irinotecan as second-line therapy in patients with gastroesophageal cancer previously treated with platinum
    • Schoennemann KR, Bjerregaard JK, Hansen T P, et al. Biweekly cetuximab and irinotecan as second-line therapy in patients with gastroesophageal cancer previously treated with platinum. Gastric Cancer. 2011;14(3):219-225.
    • (2011) Gastric Cancer , vol.14 , Issue.3 , pp. 219-225
    • Schoennemann, K.R.1    Bjerregaard, J.K.2    Hansen, T.P.3
  • 107
    • 79952847624 scopus 로고    scopus 로고
    • A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus
    • Ilson DH, Kelsen D, Shah M, et al. A phase 2 trial of erlotinib in patients with previously treated squamous cell and adenocarcinoma of the esophagus. Cancer. 2011;117(7):1409-1414.
    • (2011) Cancer , vol.117 , Issue.7 , pp. 1409-1414
    • Ilson, D.H.1    Kelsen, D.2    Shah, M.3
  • 108
    • 33750618860 scopus 로고    scopus 로고
    • Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127
    • Dragovich T, McCoy S, Fenoglio-Preiser CM, et al. Phase II trial of erlotinib in gastroesophageal junction and gastric adenocarcinomas: SWOG 0127. J Clin Oncol. 2006;24(30):4922-4927.
    • (2006) J Clin Oncol , vol.24 , Issue.30 , pp. 4922-4927
    • Dragovich, T.1    McCoy, S.2    Fenoglio-Preiser, C.M.3
  • 109
    • 33645734242 scopus 로고    scopus 로고
    • Predictive factors for outcome in a phase II study of geftinib in second-line treatment of advanced esophageal cancer patients
    • Janmaat ML, Gallegos-Ruiz MI, Rodriguez JA, et al. Predictive factors for outcome in a phase II study of geftinib in second-line treatment of advanced esophageal cancer patients. J Clin Oncol. 2006;24(10): 1612-1619.
    • (2006) J Clin Oncol , vol.24 , Issue.10 , pp. 1612-1619
    • Janmaat, M.L.1    Gallegos-Ruiz, M.I.2    Rodriguez, J.A.3
  • 110
    • 35348826772 scopus 로고    scopus 로고
    • A phase II study of geftinib monotherapy in advanced esophageal adenocarcinoma: Evidence of gene expression, cellular, and clinical response
    • Ferry DR, Anderson M, Beddard K, et al. A phase II study of geftinib monotherapy in advanced esophageal adenocarcinoma: evidence of gene expression, cellular, and clinical response. Clin Cancer Res. 2007;13(19):5869-5875.
    • (2007) Clin Cancer Res , vol.13 , Issue.19 , pp. 5869-5875
    • Ferry, D.R.1    Anderson, M.2    Beddard, K.3
  • 111
    • 84878078429 scopus 로고    scopus 로고
    • REGARD: A phase Ill, randomized, double-blind ed trial of ramucirumab and best supportive care (BSC) versus placebo and BSC in the treatment of metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma following disease progression on frst-line platinum- and/or fuoropyrimidine-containing combination therapy
    • Fuchs CS, Tomasek J, Cho JY, et al. REGARD: A phase Ill, randomized, double-blind ed trial of ramucirumab and best supportive care (BSC) versus placebo and BSC in the treatment of metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma following disease progression on frst-line platinum- and/or fuoropyrimidine-containing combination therapy. J Clin Oncol. 2012;30.
    • (2012) J Clin Oncol , pp. 30
    • Fuchs, C.S.1    Tomasek, J.2    Cho, J.Y.3
  • 112
    • 13444283451 scopus 로고    scopus 로고
    • Current management of esophageal cancer
    • Law S, Wong J. Current management of esophageal cancer. J Gastrointest Surg. 2005;9(2):291-310.
    • (2005) J Gastrointest Surg , vol.9 , Issue.2 , pp. 291-310
    • Law, S.1    Wong, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.