Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-HT6 receptors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 15, 2013, Pages 4614-4627

  Ivachtchenko, Alexandre ^a,b   Golovina, Elena ^a   Kadieva, Madina ^a   Mitkin, Oleg ^a   Tkachenko, Sergei ^b   Okun, Ilya ^b  

^a Department of Organic Chemistry   (Russian Federation)

^b CHEMDIV INC   (United States)

Author keywords

Antagonists; Diphenyl sulfones; Ligand; Molecular docking; Serotonin 5 HT6 type receptor

Indexed keywords

1 [4 (PHENYLSULFONYL)PHENYL]PIPERAZINE; 1 METHOXY 2 (PHENYLSULFONYL)BENZENE; 2 (PHENYLSULFONYL)ANILINE; 4 (4 AMINOPHENYLSULFONYL)BENZENE 1,2 DIAMINE; 5 (PIPERAZINE 1 YL) 2 (PHENYLSULFONYL)ANILINE; DAPSONE; DIPHENYL SULFONE; N ACETYL 2 (PHENYLSULFONYL) 5 (PIPERAZIN 1 YL)ANILINE; N METHYL 2 (PHENYLSULFONYL) 5 (PIPERAZIN 1 YL)ANILINE; N METHYL 2 (PHENYLSULFONYL) 5 (PYRIDIN 3 YL)ANILINE; N METHYL 2 (PHENYLSULFONYL)ANILINE; N METHYL 4 (PHENYLSULFONYL)BIPHENYL 3 AMINE; N,N DIMETHYL 2 (PHENYLSULFONYL) 5 (PIPERAZIN 1 YL)ANILINE; N,N DIMETHYL 2 (PHENYLSULFONYL)ANILINE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR DOCKING; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 84879694862     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.05.040     Document Type: Article

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