Evaluation of the anti-inflammatory activity of some pyrrolo[2,3-d] pyrimidine derivatives

Medicinal Chemistry Research

Volumn 22, Issue 5, 2013, Pages 2244-2252

  Mohamed, Mosaad S ^a   Kamel, Rehab ^a   Abd El Hameed, Rania H ^a  

^a Helwan   (Egypt)

Author keywords

Anti inflammatory activity; Pyrrolo 2,3 d pyrimidine; Pyrrolo 3,2 e 1,2,4 triazolo 4,3 c pyrimidine; Structure activity relationship

Indexed keywords

3 METHYL 7 (4 METHOXYPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; 3 METHYL 7 (4 METHOXYPHENYL) 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; 3 METHYL 7 (4 METHYLPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; 3 METHYL 7 (4 METHYLPHENYL) 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; 4 (3,5 DIMETHYL 4H PYRAZOL 1 YL) 7 (4 METHOXYPHENYL) 5,6 DIPHENYL 4,7DIHYDRO 3H PYRROLO[2,3 D]PYRIMIDINE; 4 (3,5 DIMETHYL 4H PYRAZOL 1 YL) 7 (4 METHYLPHENYL) 5 PHENYL 4,7DIHYDRO 3H PYRROLO[2,3 D]PYRIMIDINE; 4 [2 (BENZYL)HYDRAZINYL] 7 (4 METHOXYPHENYL) 5 PHENYL 7H PYRROLO[2,3 D]PYRIMIDINE; 4 [2 (BENZYL)HYDRAZINYL] 7 (4 METHOXYPHENYL) 5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDINE; 4 [2 (BENZYL)HYDRAZINYL] 7 (4 METHYLPHENYL) 5 PHENYL 7H PYRROLO[2,3 D]PYRIMIDINE; 4 [2 (BENZYL)HYDRAZINYL] 7 (4 METHYLPHENYL) 5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDINE; 7 (4 METHOXYPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMID IN 3 ONE; 7 (4 METHOXYPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMID IN 3 THIONE; 7 (4 METHOXYPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; 7 (4 METHOXYPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E]TETRAZOLO[1,5 C]PYRIMIDINE; 7 (4 METHOXYPHENYL) 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDIN 3 THIONE; 7 (4 METHOXYPHENYL) 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; 7 (4 METHYLPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRAMID IN 3 THIONE; 7 (4 METHYLPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMID IN 3 ONE; 7 (4 METHYLPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; 7 (4 METHYLPHENYL) 8,9 DIPHENYL 7H PYRROLO[3,2 E]TETRAZOLO[1,5 C]PYRIMIDINE; 7 (4 METHYLPHENYL) 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDIN 3 THIONE; 7 (4 METHYLPHENYL) 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[4,3 C]PYRIMIDINE; [7 (4 METHOXYPHENYL) 5 PHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL] HYDRAZINE; [7 (4 METHOXYPHENYL) 5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL] HYDRAZINE; [7 (4 METHYLPHENYL) 5 PHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL] HYDRAZINE; [7 (4 METHYLPHENYL) 5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 YL] HYDRAZINE; ANTIINFLAMMATORY AGENT; IBUPROFEN; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 84879686230     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0217-5     Document Type: Article

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