Berberine inhibits norepinephrine-induced apoptosis in neonatal rat cardiomyocytes via inhibiting ROS-TNF-α-caspase signaling pathway

Chinese Journal of Integrative Medicine

Volumn 19, Issue 6, 2013, Pages 424-431

  Lv, Xiu Xiu ^a   Yu, Xiao Hui ^a   Wang, Hua Dong ^a,b   Yan, Yu Xia ^a   Wang, Yan Ping ^a   Lu, Da Xiang ^a,b   Qi, Ren Bin ^a,b   Hu, Chao Feng ^a   Li, Hong Mei ^a,b  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

apoptosis; berberine; cardiomyocytes; norepinephrine

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BERBERINE; CASPASE 2; CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; LACTATE DEHYDROGENASE; LIPOCORTIN 5; NORADRENALIN; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE; HEART MUSCLE CELL; IMMUNOCYTOCHEMISTRY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; STAINING;

ANIMALS; ANIMALS, NEWBORN; ANNEXIN A5; APOPTOSIS; BERBERINE; CASPASE 2; CASPASE 3; CASPASES; CELL NUCLEUS; CELL SHAPE; DNA; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCEIN-5-ISOTHIOCYANATE; IMMUNOHISTOCHEMISTRY; L-LACTATE DEHYDROGENASE; MYOCYTES, CARDIAC; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84879684892     PISSN: 16720415     EISSN: 19930402     Source Type: Journal    
DOI: 10.1007/s11655-011-0856-2     Document Type: Article

References (26)

1. Haskings GJ, Esler MD, Jennings GL, Burton D, Korner PI. Norepinephrine spillover to plasma in patients with chronic congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 1986;73:615-621.
2. Pepper GS, Lee RW. Sympathetic activation in heart failure and its treatment with beta-blockade. Arch Intern Med 1999;159:225-234.
3. Communal C, Singh K, Pimentel DR, Colucci WS. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the beta-adrenergic pathway. Circulation 1998;98:1329-1334.
4. Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL. Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species - TNFα-caspase signaling pathway. Cardiovasc Res 2004;62:558-567.
5. Narula J, Haider N, Virmani R, Disalvo TG, Kolodgie FD, Hajjar RJ, et al. Apoptosis in myocytes in end-stage heart failure. N Engl J Med 1996;335:1182-1189.
6. Li Z, Bing OHL, Long X, Robinson KG, Lakatta E. Increased cardiomyocyte apoptosis during transition to heart failure in the spontaneously hypertensive rats. Am J Physiol 1997;272:H2313-H2319.
7. Sharov VG, Sabbah HN, Shimoyama H, Goussev AV, Lesch M, Goldstein S. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure. Am J Pathol 1996;148:141-149.
8. Moorjani N, Ahmad M, Catarino P, Brittin R, Trabzuni D, Al-Mohanna F, et al. Activation of apoptotic caspase cascade during the transition to pressure overload-induced heart failure. J Am Coll Cardiol 2006;48:1451-1458.
9. Lee Y, Gustafsson AB. Role of apoptosis in cardiovascular disease. Apoptosis 2009;14:536-548.
10. Lau CW, Yao XQ, Chen ZY, Ko WH, Huang Y. Cardiovascular actions of berberine. Cardiovasc Drug Rev 2001;19:234-244.
11. Hong Y, Hui SC, Chan TY, Hou JY. Effect of berberine on regression of pressure -overload induced cardiac hypertrophy in rats. Am J Chin Med 2002;30:589-599.
12. Zeng XH, Zeng XJ, Li YY. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 2003;92:173-176.
13. Wang Y, Huang Y, Lam KS, Li Y, Wong WT, Ye H, et al. Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovasc Res 2009;82:484-492.
14. Zheng L, Zhou Z, Tao D, Lan T. Protective effect of berberine on cardiac myocyte injured by ischemia-reperfusion. J Sichuan Univ (Med Sci Edi) (Chin) 2003;34:452-454.
15. Chen HW, Chien CT, Yu SL, Lee YT, Chen WJ. Cyclosporine A regulate oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via ROS generation, iNOS and Hsp70. Br J Pharmacol 2002;37:771-781.
16. Krown KA, Page MT, Nguyen C, Zechner D, Gutierrez V, Comstock KL, et al. Tumor necrosis factor alphainduced apoptosis in cardiac myocytes: involvement of the sphingolipid signaling cascade in cardiac cell death. J Clin Invest 1996;98:2854-2865.
17. Remondino A, Kwon SH, Communal C, Pimentel DR, Sawyer DB, Singh K, et al. Beta-Adrenergic receptor stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species-jun NH2-terminal kinasedependent activation of the mitochondrial pathway. Circ Res 2003;92:136-138.
18. Mantena SK, Sharma SD, Katiyar SK. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther 2006;5:296-308.
19. Jantova S, Cipak L, Letasiova S. Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells. Toxicol In Vitro 2007;21:25-31.
20. Meeran SM, Katiyar S, Katiyar SK. Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation. Toxicol Appl Pharmacol 2008;229:33-43.
21. Ho YT, Lu CC, Yang JS, Chiang JH, Li TC, Lp SW, et al. Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells. Anticancer Res 2009;29:4063-4070.
22. Zhou XQ, Zeng XN, Kong H, Sun XL. Neuroprotective effects of berberine on stroke models in vitro and in vivo. Neurosci Lett 2008;447:31-36.
23. Robertson JD, Enoksson M, Suomela M, Zhivotovsky B, Orrenius S. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during toposide-induced apoptosis. J Biol Chem 2002;277:29803-29809.
24. Hong Y, Hui SS, Chan BT, Hou J. Effect of berberine on catecholamine levels in rats with experimental cardiac hypertrophy. Life Sci 2003;72:2499-2507.
25. Lu DY, Tang CH, Chen YH, Wei IH. Berberine suppresses neuroinflammatory responses through AMP-activated protein kinase activation in BV-2 microglia. J Cell Biochem 2010;110:697-705.
26. Kewalramani G, Puthanveetil P, Wang F, Kim MS, Deppe S, Abrahani A, et al. AMP-activated protein kinase confers protection against TNF-α-induced cardiac cell death. Cardiovasc Res 2009;84:42-53.