Methylene blue-mediated photodynamic therapy enhances apoptosis in lung cancer cells

Oncology Reports

Volumn 30, Issue 2, 2013, Pages 856-862

  Lim, Eun Jin ^a   Oak, Chul Ho ^a   Heo, Jeonghoon ^a   Kim, Young Ho ^a  

^a Kosin University College of Medicine   (South Korea)

Author keywords

Apoptosis; Lung; Methylene blue; Photodynamic therapy

Indexed keywords

ACETYLCYSTEINE; METHYLENE BLUE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; PROTEIN BCL 2; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; METHYLENE BLUE; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 84879675660     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2494     Document Type: Article

References (23)

1. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J and Peng Q: Photodynamic therapy. J Natl Cancer Inst 90: 889-905, 1998. (Pubitemid 28304157)
2. Dolmans DE, Fukumura D and Jain RK: Photodynamic therapy for cancer. Nat Rev Cancer 3: 380-387, 2003. (Pubitemid 37328858)
3. Sharman WM, Allen CM and van Lier JE: Photodynamic therapeutics: basic principles and clinical applications. Drug Discov Today 4: 507-517, 1999. (Pubitemid 29497854)
4. Bisland SK, Chien C, Wilson BC and Burch S: Pre-clinical in vitro and in vivo studies to examine the potential use of photodynamic therapy in the treatment of osteomyelitis. Photochem Photobiol Sci 5: 31-38, 2006.
5. Tardivo JP, Del Giglio A, Paschoal LH and Baptista MS: New photodynamic therapy protocol to treat AIDS-related Kaposi's sarcoma. Photomed Laser Surg 24: 528-531, 2006. (Pubitemid 44689872)
6. Wagner M, Suarez ER, Theodoro TR, Machado Filho CD, Gama MF, Tardivo JP, Paschoal FM and Pinhal MA: Methylene blue photodynamic therapy in malignant melanoma decreases expression of proliferating cell nuclear antigen and heparanases. Clin Exp Dermatol 37: 527-533, 2012.
7. Kirszberg C, Rumjanek VM and Capella MA: Methylene blue is more toxic to erythroleukemic cells than to normal peripheral blood mononuclear cells: a possible use in chemotherapy. Cancer Chemother Pharmacol 56: 659-665, 2005. (Pubitemid 41425064)
8. Ball DJ, Luo Y, Kessel D, Griffiths J, Brown SB and Vernon DI: The induction of apoptosis by a positively charged methylene blue derivative. J Photochem Photobiol B 42: 159-163, 1998. (Pubitemid 28142337)
9. Noodt BB, Rodal GH, Wainwright M, Peng Q, Horobin R, Nesland JM and Berg K: Apoptosis induction by different pathways with methylene blue derivative and light from mitochondrial sites in V79 cells. Int J Cancer 75: 941-948, 1988.
10. Rodrigues T, de França LP, Kawai C, de Faria PA, Mugnol KC, Braga FM, Tersariol IL, Smaili SS and Nantes IL: Protective role of mitochondrial unsaturated lipids on the preservation of the apoptotic ability of cytochrome C exposed to singlet oxygen. J Biol Chem 282: 25577-25587, 2007. (Pubitemid 47372794)
11. Gabrielli D, Belisle E, Severino D, Kowaltowski AJ and Baptista MS: Binding, aggregation and photochemical properties of methylene blue in mitochondrial suspensions. Photochem Photobiol 79: 227-232, 2004.
12. Chen Y, Zheng W, Li Y, Zhong J, Ji J and Shen P: Apoptosis induced by methylene-blue-mediated photodynamic therapy in melanomas and the involvement of mitochondrial dysfunction revealed by proteomics. Cancer Sci 99: 2019-2027, 2008.
13. Lu Y, Jiao R, Chen X, Zhong J, Ji J and Shen P: Methylene blue-mediated photodynamic therapy induces mitochondria-dependent apoptosis in HeLa cell. J Cell Biochem 105: 1451-1460, 2008.
14. Kim MJ, Lee TH, Kim SH, Choi YJ, Heo J and Kim YH: Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway. Int J Oncol 37: 1177-1185, 2010.
15. Szatrowski TP and Nathan CF: Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51: 794-798, 1991.
16. Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418, 2000. (Pubitemid 32162623)
17. Firczuk M, Winiarska M, Szokalska A, Jodlowska M, Swiech M, Bojarczuk K, Salwa P and Nowis D: Approaches to improve photodynamic therapy of cancer. Front Biosci 16: 208-224, 2011.
18. Nahabedian MY, Cohen RA, Contino MF, Terem TM, Wright WH, Berns MW and Wile AG: Combination cytotoxic chemotherapy with cisplatin or doxorubicin and photodynamic therapy in murine tumors. J Natl Cancer Inst 80: 739-743, 1988.
19. Peng Q, Warloe T, Moan J, Godal A, Apricena F, Giercksky KE and Nesland JM: Antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy can be enhanced by the use of a low dose of photofrin in human tumor xenografts. Cancer Res 61: 5824-5832, 2001. (Pubitemid 32769101)
20. Sherlock DJ and Holl-Allen RT: Intravital methylene blue staining of parathyroid glands and tumours. Ann R Coll Surg Engl 66: 396-398, 1984. (Pubitemid 14022266)
21. Meissner PE, Mandi G, Coulibaly B, Witte S, Tapsoba T, Mansmann U, Rengelshausen J, Schiek W, Jahn A, Walter-Sack I, Mikus G, Burhenne J, Riedel KD, Schirmer RH, Kouyaté B and Müller O: Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine. Malar J 5: 84, 2006.
22. Yang ES, Choi MJ, Kim JH, Choi KS and Kwon TK: Combination of withaferin A and X-ray irradiation enhances apoptosis in U937 cells. Toxicol In Vitro 25: 1803-1810, 2011.
23. Chen YR and Tan TH: The c-Jun N-terminal kinase pathway and apoptotic signaling. Int J Oncol 16: 651-662, 2000.