High-altitude medicine

American Journal of Respiratory and Critical Care Medicine

Volumn 186, Issue 12, 2012, Pages 1229-1237

  West, John B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Genetic changes; Hypoxia; Hypoxia inducible factors; Oxygen enrichment of room air; Oxygen sensing

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; OXIDOREDUCTASE; OXYGEN;

AIRCRAFT; ALTITUDE; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; AMBIENT AIR; BRAIN EDEMA; CAPILLARY DENSITY; CELL HYPOXIA; CHINA; GENETIC DIFFERENCE; HUMAN; HYPERVENTILATION; HYPOXIC LUNG VASOCONSTRICTION; LUNG EDEMA; MEDICAL ERROR; MEDICINE; MINING; OXYGEN CONCENTRATION; PATHOPHYSIOLOGY; PHENOTYPE; POLYCYTHEMIA; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW;

ACCLIMATIZATION; ALTITUDE; ALTITUDE SICKNESS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; HUMANS; SOUTH AMERICA; TIBET;

EID: 84871739357     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201207-1323CI     Document Type: Review

References (75)

1. West JB, Lahiri S, Maret KH, Peters RM Jr, Pizzo CJ. Barometric pressures at extreme altitudes on Mt. Everest: physiological significance. J Appl Physiol 1983a;54:1188-1194. (Pubitemid 13098962)
2. Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992;12:5447-5454.
3. Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell 2012;148:399-408.
4. Nocturnal Oxygen Therapy Trial Group. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: a clinical trial. Ann Intern Med 1980;93:391-398.
5. Forster P. Telescopes in high places. In: D. Heath, editor. Aspects of hypoxia. Liverpool, UK: Liverpool University Press, 1986. p. 217-233.
6. Barcroft J. The Respiratory function of the blood. Part I. Lessons from high altitudes. Cambridge, UK: Cambridge University Press, 1925.
7. Marconi C, Marzorati M, Cerretelli P. Work capacity of permanent residents of high altitude. High Alt Med Biol 2006;7:105-115. (Pubitemid 44043590)
8. Beall CM. Tibetan and Andean patterns of adaptation to high-altitude hypoxia. Hum Biol 2000;72:201-228. (Pubitemid 30132306)
9. Wu T, Li S, Ward MP. Tibetans at extreme altitude. Wilderness Environ Med 2005;16:47-54. (Pubitemid 40411605)
10. Moore LG. Human genetic adaptation to high altitude. High Alt Med Biol 2001;2:257-279. (Pubitemid 32677861)
11. Groves BM, Droma T, Sutton JR, McCullough RG, Zhuang J, Rapmund G, Sun S, Janes C, Moore LG. Minimal hypoxic pulmonary hypertension in normal Tibetans at 3,658 m. J Appl Physiol 1993;74:312-318. (Pubitemid 23059762)
12. Hoit BD, Dalton ND, Erzurum SC, Laskowski D, Strohl KP, Beall CM. Nitric oxide and cardiopulmonary hemodynamics in Tibetan highlanders. J Appl Physiol 2005;99:1796-1801. (Pubitemid 41547177)
13. Erzurum SC, Ghosh S, Janocha AJ, Xu W, Bauer S, Bryan NS, Tejero J, Hemann C, Hille R, Stuehr DJ, et al. Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc Natl Acad Sci USA 2007;104:17593-17598. (Pubitemid 350210880)
14. Niermeyer S, Yang P, Shanmina, Drolkar, Zhuang J, Moore LG. Arterial oxygen saturation in Tibetan and Han infants born in Lhasa, Tibet. N Engl J Med 1995;333:1248-1252.
15. Aggarwal S, Negi S, Jha P, Singh PK, Stobdan T, Pasha MA, Ghosh S, Agrawal A; Indian Genome Variation Consortium, Prasher B, Mukerji M. EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda. Proc Natl Acad Sci USA 2010;107:18961-18966.
16. Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, et al. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci USA 2010;107:11459-11464.
17. Bigham A, Bauchet M, Pinto D, Mao X, Akey JM, Mei R, Scherer SW, Julian CG, Wilson MJ, López Herrá ez D, et al. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet 2010;6:e1001116.
18. Peng Y, Yang Z, Zhang H, Cui C, Qi X, Luo X, Tao X, Wu T, Ouzhuluobu, Basang, Ciwangsangbu, Danzengduojie, Chen H, Shi H, Su B. Genetic variations in Tibetan populations and high altitude adaptation at the Himalayas. Mol Biol Evol 2011;28:1075-1081.
19. Simonson TS, Yang Y, Huff CD, Yun H, Qin G,Witherspoon DJ, Bai Z, Lorenzo FR, Xing J, Jorde LB, et al. Genetic evidence for high-altitude adaptation in Tibet. Science 2010;329:72-75.
20. Xu S, Li S, Yang Y, Tan J, Lou H, Jin W, Yang L, Pan X, Wang J, Shen Y, et al. A genome-wide search for signals of high altitude adaptation in Tibetans. Mol Biol Evol 2010;28:1003-1011.
21. Yi X, Liang Y, Huerta-Sanchez E, Jin X, Cuo ZX, Pool JE, Xu X, Jiang H, Vinckenbosch N, Korneliussen TS, et al. Sequencing of 50 human exomes reveals adaptation to high altitude. Science 2010;329:75-78.
22. Aldenderfer M. Peopling the Tibetan plateau: insights from archaeology. High Alt Med Biol 2011;12:141-147.
23. MacInnis MJ, Koehle MS, Rupert JL. Evidence for a genetic basis for altitude illness: 2010 update. High Alt Med Biol 2010;11:349-368.
24. Luks AM, McIntosh SE, Grissom CK, Auerbach PS, Rodway GW, Schoene RB, Zafren K, Hackett PH; Wilderness Medical Society. Wilderness Medical Society consensus guidelines for the prevention and treatment of acute altitude illness. Wilderness Environ Med 2010;21:146-155.
25. Murdoch D. Altitude illness among tourists flying to 3740 meters elevation in the Nepal Himalayas. J Travel Med 1995a;2:255-256.
26. Kayser B. Acute mountain sickness in western tourists around the Thorong pass (5400m) in Nepal. J Wilderness Med 1991;2:110-117.
27. Hackett PH, Rennie D, Levine HD. The incidence, importance and prophylaxis of acute mountain sickness. Lancet 1976;2:1149-1154.
28. Roach RC, Houston CS, Honigman B, Nicholas RA, Yaron M, Grissom CK, Alexander JK, Hultgren HN. How do older persons tolerate moderate altitude? West J Med 1995;162:32-36.
29. Richalet J-P, Keromes A, Dersch B, Corizzi F, Mehdioui H, Pophillat B, Chardonnet H, Tassery F, Herry J-P, Rathat C, et al. Caractéristiques physiologiques des alpinistes de haute altitude. Sci Sports 1988;3:89-108.
30. Milledge JS, Thomas PS, Beeley JM, English JS. Hypoxic ventilatory response and acute mountain sickness. Eur Respir J 1988;1:948-951. (Pubitemid 19015310)
31. Burtscher M, Flatz M, Faulhaber M. Prediction of susceptibility to acute mountain sickness by SaO2 values during short-term exposure to hypoxia. High Alt Med Biol 2004;5:335-340. (Pubitemid 39369234)
32. Roach RC, Greene ER, Schoene RB, Hackett PH. Arterial oxygen saturation for prediction of acute mountain sickness. Aviat Space Environ Med 1998;69:1182-1185. (Pubitemid 28544216)
33. Roach RC, Maes D, Sandoval D, Robergs RA, Icenogle M, Hinghofer-Szalkay H, Lium D, Loeppky JA. Exercise exacerbates acute mountain sickness at simulated high altitude. J Appl Physiol 2000;88:581-585. (Pubitemid 30097102)
34. Singh I, Khanna PK, Srivastava MC, Lal M, Roy SB, Subramanyam CS. Acute mountain sickness. N Engl J Med 1969;280:175-184.
35. Bailey DM, Roukens R, Knauth M, Kallenberg K, Christ S, Mohr A, Genius J, Storch-Hagenlocher B, Meisel F, McEneny J, et al. Free radical-mediated damage to barrier function is not associated with altered brain morphology in high-altitude headache. J Cereb Blood Flow Metab 2006;26:99-111. (Pubitemid 41818074)
36. Richalet J-P, Hornych A, Rathat C, Aumont J, Lormignat P, Rémy P. Plasma prostaglandins, leukotrienes and thromboxane in acute high altitude hypoxia. Respir Physiol 1991;85:205-215.
37. Hackett PH, Rennie D, Hofmeister SE, Grover RF, Grover EB, Reeves JT. Fluid retention and relative hypoventilation in acute mountain sickness. Respiration 1982;43:321-329. (Pubitemid 12024407)
38. Kayser B, Dumont L, Lysakowski C, Combescure C, Haller G, Tramèr MR. Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis. High Alt Med Biol 2012;13:82-92.
39. Lipman GS, Kanaan NC, Holck PS, Constance BB, Gertsch JH. PAINS Group. Ibuprofen prevents altitude illness: a randomized controlled trial for prevention of altitude illness with nonsteroidal anti-inflammatories. Ann Emerg Med 2012;59:484-490.
40. Menon ND. High altitude pulmonary edema: a clinical study. N Engl J Med 1965;273:66-73.
41. Hultgren HN, Marticorena EA. High altitude pulmonary edema: epidemiologic observations in Peru. Chest 1978;74:372-376. (Pubitemid 9047783)
42. Bärtsch P, Baumgartner RW, Waber U, Maggiorini M, Oelz O. Comparison of carbon dioxide enriched, oxygen enriched, and normal air in treatment of acute mountain sickness. Lancet 1990;336:772-775. (Pubitemid 20312188)
43. Hultgren HN, Lopez CE, Lundberg E, Miller H. Physiologic studies of pulmonary edema at high altitude. Circulation 1964;29:393-408.
44. Antezana G, Leguia G, Guzman AM, Coudert J, Spielvogel H. Hemodynamic study of high altitude pulmonary edema (12200 ft). In: Brendel W, Zink RA, editors. High altitude physiology and medicine. New York: Springer-Verlag; 1982. pp. 232-241.
45. Hultgren HN, Grover RF, Hartley LH. Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation 1971;44:759-770.
46. Bärtsch P, Pfluger N, Audétat M, Shaw S, Weidmann P, Vock P, Vetter W, Rennie D, Oelz O. Effects of slow ascent to 4559m on fluid homeostasis. Aviat Space Environ Med 1991a;62:105-110.
47. Houston CS. Acute pulmonary edema of high altitude. N Engl J Med 1960;263:478-480.
48. Hackett PH, Creagh CE, Grover RF, Honigman B, Houston CS, Reeves JT, Sophocles AM, Van Hardenbroek M. High altitude pulmonary edema in persons without the right pulmonary artery. N Engl J Med 1980;302:1070-1073. (Pubitemid 10123110)
49. Schoene RB, Swenson ER, Pizzo CJ, Hackett PH, Roach RC, Mills WJ Jr, Henderson WR Jr, Martin TR. The lung at high altitude: bronchoalveolar lavage in acute mountain sickness and pulmonary edema. J Appl Physiol 1988;64:2605-2613.
50. Hackett PH, Bertman J, Rodriguez G. Pulmonary edema fluid protein in high-altitude pulmonary edema. JAMA 1986;256:36.
51. Tsukimoto K, Mathieu-Costello O, Prediletto R, Elliott AE, West JB. Ultrastructural appearances of pulmonary capillaries at high transmural pressures. J Appl Physiol 1991;71:573-582.
52. West JB, Tsukimoto K, Mathieu-Costello O, Prediletto R. Stress failure in pulmonary capillaries. J Appl Physiol 1991;70:1731-1742.
53. Hackett PH, Roach RC. Current concepts: high-altitude illness. N Engl J Med 2001;345:107-114.
54. Bärtsch P, Maggiorini M, Ritter M, Noti C, Vock P, Oelz O. Prevention of high-altitude pulmonary edema by nifedipine. N Engl J Med 1991b;325:1284-1289.
55. Hackett PH, Roach RC. High altitude cerebral edema. High Alt Med Biol 2004;5:136-146. (Pubitemid 39069615)
56. Houston CS, Dickinson J. Cerebral form of high-altitude illness. Lancet 1975;2:758-761.
57. Hackett PH, Yarnell PR, Hill R, Reynard K, Heit J, McCormick J. High-altitude cerebral edema evaluated with magnetic resonance imaging. JAMA 1998;280:1920-1925.
58. Hurtado A. Chronic mountain sickness. JAMA 1942;120:1278-1282.
59. Richalet JP, Rivera M, Bouchet P, Chirinos E, Onnen I, Petitjean O, Bienvenu A, Lasne F, Moutereau S, León-Velarde F. Acetazolamide: a treatment for chronic mountain sickness. Am J Respir Crit Care Med 2005b;172:1427-1433. (Pubitemid 43069816)
60. Anand IS, Malhotra RM, Chandrashekhar Y, Bali HK, Chauhan SS, Jindal SK, Bhandari RK, Wahi PL. Adult subacute mountain sickness: a syndrome of congestive heart failure in man at very high altitude. Lancet 1990;335:561-565. (Pubitemid 20089240)
61. Wu TY. Chronic mountain sickness on the Qinghai-Tibetan plateau. Chin Med J (Engl) 2005;118:161-168.
62. Hecht HH, Lange RL, Carnes WH, Kuida H, Blake JT. Brisket disease: I. General aspects of pulmonary hypertensive heart disease in cattle. Trans Assoc Am Physiol 1959;72:157-172.
63. Wu T-Y, Liu YR. High altitude heart disease. Zhonghua Er Ke Za Zhi 1995;6:348-350.
64. Sui GJ, Liu YH, Cheng XS, Anand IS, Harris E, Harris P, Heath D. Subacute infantile mountain sickness. J Pathol 1988;155:161-170.
65. West JB. Oxygen enrichment of room air to relieve the hypoxia of high altitude. Respir Physiol 1995;99:225-232.
66. West JB, Readhead A. Working at high altitude: medical problems, misconceptions, and solutions. Observatory 2004;124:1-14. (Pubitemid 38284469)
67. West JB. Fire hazard in oxygen-enriched atmospheres at low barometric pressures. Aviat Space Environ Med 1997;68:159-162. (Pubitemid 27066741)
68. West JB. Potential use of oxygen enrichment of room air in mountain resorts. High Alt Med Biol 2002b;3:59-64. (Pubitemid 34436673)
69. Luks AM, van Melick H, Batarse RR, Powell FL, Grant I, West JB. Room oxygen enrichment improves sleep and subsequent day-time performance at high altitude. Respir Physiol 1998;113:247-258. (Pubitemid 28493386)
70. Frisancho AR, Baker PT. Altitude and growth: a study of the patterns of physical growth of a high altitude Peruvian Quechua population. Am J Phys Anthropol 1970;32:279-292.
71. Richalet JP, Donoso MV, Jiménez D, Antezana AM, Hudson C, Cortès G, Osorio J, Leòn A. Chilean miners commuting from sea level to 4500m: a prospective study. High Alt Med Biol 2002;3:159-166.
72. Anand IS. Letter from the field: letter from Siachen Glacier. High Alt Med Biol 2001;2:553-557.
73. Jha SK, Anand AC, Sharma V, Kumar N, Adya CM. Stroke at high altitude: Indian experience. High Alt Med Biol 2002;3:21-27. (Pubitemid 34436669)
74. Rahn H, Otis AB. Man's respiratory response during and after acclimatization to high altitude. Am J Physiol 1949;157:445-462.
75. Wilson DF, Roy A, Lahiri S. Immediate and long-term responses of the carotid body to high altitude. High Alt Med Biol 2005;6:97-111. (Pubitemid 41386660)