Altered pulmonary vascular reactivity in mice with excessive erythrocytosis

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 7, 2004, Pages 829-835

  Hasegawa, Jo ^b   Wagner, Klaus F ^b   Karp, Dörte ^b   Li, Dechun ^b   Shibata, Junpei ^b   Heringlake, Matthias ^b   Bahlmann, Ludger ^b   Depping, Reinhard ^b   Fandrey, Joachim ^b   Schmucker, Peter ^b   Uhlig, Stefan ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b NONE

Author keywords

Erythropoietin; Isolated mouse lung; Pulmonary hypertension; Vascular remodeling

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ERYTHROPOIETIN; NITRIC OXIDE SYNTHASE; OXYGEN; PROSTACYCLIN; THROMBOXANE RECEPTOR STIMULATING AGENT;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; BLOOD VISCOSITY; CONTROLLED STUDY; ERYTHROCYTOSIS; GENE OVEREXPRESSION; HEART OUTPUT; HEART RATE; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG PERFUSION; MOUSE; NONHUMAN; POLYCYTHEMIA; PRIORITY JOURNAL; PULMONARY HYPERTENSION; THICKNESS; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE; WILD TYPE;

EID: 12144289457     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200308-1154oc     Document Type: Article

References (40)

1. Seigne PW, Hartigan PM, Body SC. Anesthetic considerations for patients with severe emphysematous lung disease. Int Anesthesiol Clin 2000;38:1-23.
2. Peinado VI, Santos S, Ramirez J, Roca J, Rodriguez-Roisin R, Barbera JA. Response to hypoxia of pulmonary arteries in chronic obstructive pulmonary disease: an in vitro study. Eur Respir J 2002;20:332-338.
3. Meyrick B. The pathology of pulmonary artery hypertension. Clin Chest Med 2001;22:393-404.
4. Ruschitzka FT, Wenger RH, Stallmach T, Quaschning T, de Wit C, Wagner K, Labugger R, Kelm M, Noll G, Rulicke T, et al. Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin. Proc Natl Acad Sci USA 2000; 97:11609-11613.
5. Wagner KF, Katschinski DM, Hasegawa J, Schumacher D, Meller B, Gembruch U, Schramm U, Jelkmann W, Gassmann M, Fandrey J. Chronic inborn erythrocytosis leads to cardiac dysfunction and premature death in mice overexpressing erythropoietin. Blood 2001;97: 536-542.
6. Wagner KF, Hasegawa J, Shibata J, Li D, Heringlake M, Karp D, Uhlig S. Altered pulmonary vascular reactivity in transgenic mice with excessive erythrocytosis [abstract]. Am J Respir Crit Care Med 2003;167: A698.
7. von Bethmann AN, Brasch F, Nüsing R, Vogt K, Volk HD, Müller KM, Wendel A, Uhlig S. Hyperventilation induces release of cytokines from perfused mouse lung. Am J Respir Crit Care Med 1998;157:263-272.
8. Held HD, Martin C, Uhlig S. Characterization of airway and vascular responses in murine lungs. Br J Pharmacol 1999;126:1191-1199.
9. Held HD, Uhlig S. Basal lung mechanics and airway and pulmonary vascular responsiveness in different inbred mouse strains. J Appl Physiol 2000;88:2192-2198.
10. Romeis B. Mikroskopische Technik, 17th ed. Munich: Urban & Schwarzenberg; 1989.
11. Bancroft JD, Stevens A. Theory and practice of histological techniques, 3rd ed. Edinburgh, London, Melbourne, New York: Churchill Livingstone; 1990.
12. Quinlan TR, Li D, Laubach VE, Shesely EG, Zhou N, Johns RA. eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 2000;279:L641-L650.
13. Permutt B. Mechanical influences on water accumulation in the lung. In: Fishman A, Renkin EMJ, editors. Pulmonary edema. Bethesda, MD: American Physiological Society; 1979. p. 175-194.
14. Culver BH, Butler J. Mechanical influences on the pulmonary microcirculation. Annu Rev Physiol 1980;42:187-198.
15. Dritsas KG, Brown D, Couves CM. Effect of alveolar pleural pressures on interstitial pressures in isolated dog lungs. J Appl Physiol 1969;65: 611-616.
16. Petit RD, Warburton RR, Ou LC, Hill NS. Pulmonary vascular adaptations to augmented polycythemia during chronic hypoxia. J Appl Physiol 1995;79:229-235.
17. Defouilloy C, Teiger E, Sediame S, Andrivet P, Roudot-Thoraval F, Chouaid C, Housset B, Adnot S. Polycythemia impairs vasodilator response to acetylcholine in patients with chronic hypoxemic lung disease. Am J Respir Crit Care Med 1998;157:1452-1460.
18. Shibata J, Hasegawa J, Siemens HJ, Wolber E, Dibbelt L, Li D, Katschinski DM, Fandrey J, Jelkmann W, Gassmann M, et al. Hemostasis and coagulation at a hematocrit of 0.85: functional consequences of erythrocytosis. Blood 2003;101:4416-4422.
19. Vogel J, Kießling I, Heinicke K, Stallmach T, Ossent P, Vogel O, Aulmann M, Frietsch T, Schmid-Schonbein H, Kuschinsky W, et al. Transgenic mice overexpressing erythropoietin adapt to excessive erythrocytosis by regulating blood viscosity. Blood 2003;102:2278-2284.
20. Wilcox CS, Deng X, Doll AH, Snellen H, Welch WJ. Nitric oxide mediates renal vasodilation during erythropoietin-induced polycythemia. Kidney Int 1993;44:430-435.
21. Banerjee D, Rodriguez M, Nag M, Adamson JW. Exposure of endothelial cells to recombinant human erythropoietin induces nitric oxide synthase activity. Kidney Int 2000;57:1895-1904.
22. Ito C, Kusano E, Furukawa Y, Yamamoto H, Takeda S, Akimoto T, Rimura O, Ando Y, Asano Y. Modulation of the erythropoietin-induced proliferative pathway by cAMP in vascular smooth muscle cells. Am J Physiol Cell Physiol 2002;283:C1715-C1721.
23. Mitani Y, Maruyama K, Sakurai M. Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation 1997;96:689-697.
24. Walker BR, Resta TC, Nelin LD. Nitric oxide-dependent pulmonary vasodilation in polycythemic rats. Am J Physiol Heart Circ Physiol 2000; 279:H2382-H2389.
25. Rabinovitch M, Gamble W, Nadas AS, Miettinen OS, Reid L. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol 1979;236:H818-H827.
26. Meyrick B, Reid L. Hypoxia-induced structural changes in the media and adventitia of rat hilar pulmonary artery and their regression. Am J Pathol 1980;100:151-178.
27. Clozel JP, Saunier C, Hartemann D, Fischli W. Effects of cilazapril, a novel angiotensin converting enzyme inhibitor, on the structure of pulmonary arteries of rats exposed to chronic hypoxia. J Cardiovasc Pharmacol 1991;17:36-40.
28. van Suylen RJ, Smits JF, Daemen MJ. Pulmonary artery remodeling differs in hypoxia-and monocrotaline-induced pulmonary hypertension. Am J Respir Crit Care Med 1998;157:1423-1428.
29. Nakanishi K, Tajima F, Osada H, Nakamura A, Yagura S, Kawai T, Suzuki M, Torikata C. Pulmonary, vascular responses in rats exposed to chronic hypobaric hypoxia at two different altitude levels. Pathol Res Pract 1996;192:1057-1067.
30. Wiessner C, Allegrini PR, Ekatodramis D, Jewell UR, Stallmach T, Gassmann M. Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin. J Cereb Blood Flow Metab 2001;21: 857-864.
31. Swales JD, Evans DB. Erythraemia in renal transplantation. BMJ 1969;2:80-83.
32. Swetnam SM, Yabek SM, Alverson DC. Hemodynamic consequences of neonatal polycythemia. J Pediatr 1987;110:443-447.
33. Pearson TC. Rheology of the absolute polycythaemias. Baillieres Clin Haematol 1987;1:637-664.
34. Jefferson JA, Escudero E, Hurtado ME, Pando J, Tapia R, Swenson ER, Prchal J, Schreiner GF, Schoene RB, Hurtado A, et al. Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels. Lancet 2002;359:407-408.
35. Winslow R. High-altitude polycythemia. In: West JB, Lahiri S, editors. High altitude and man. Bethesda, MD: American Physiological Society; 1984.
36. Murphy S. Polycythemia vera. Dis Mon 1992;38:153-212.
37. Renzetti AD Jr, McClement JH, Litt BD. The Veterans Administration cooperative study of pulmonary function: 3: mortality in relation to respiratory function in chronic obstructive pulmonary disease. Am J Med 1966;41:115-129.
38. Jefferson JA, Escudero E, Hurtado ME, Pando J, Tapia R, Swenson ER, Prchal J, Schreiner GF, Schoene RB, Hurtado A, et al. Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels. Lancet 2002;359:407-408.
39. Remuzzi G, Perico N. Routine renin-angiotensin system blockade in renal transplantation? Curr Opin Nephrol Hypertens 2002;11:1-10.
40. Plata R, Cornejo A, Arratia C, Anabaya A, Perna A, Dimitrov BD, Remuzzi G, Ruggenenti P. Angiotensin-converting-enzyme inhibition therapy in altitude polycythemia: a prospective randomised trial. Lancet 2002;359:663-666.