Biochemical and biophysical characterization of four EphB kinase domains reveals contrasting thermodynamic, kinetic and inhibition profiles

Bioscience Reports

Volumn 33, Issue 3, 2013, Pages 427-437

  Overman, Ross C ^a   Debreczeni, Judit E ^a   Truman, Caroline M ^a   McAlister, Mark S ^a   Attwood, Teresa K ^b  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

EphB1; EphB2; EphB3; EphB4; Kinase inhibition; Protein stability

Indexed keywords

EPHRIN RECEPTOR B1; EPHRIN RECEPTOR B2; EPHRIN RECEPTOR B3; EPHRIN RECEPTOR B4; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; EPHRIN RECEPTOR; PROTEIN KINASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PHOSPHORYLATION; ENZYME STABILITY; ESCHERICHIA COLI; HUMAN; IC 50; LIGAND BINDING; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN UNFOLDING; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

ESCHERICHIA COLI;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; ENZYME STABILITY; ESCHERICHIA COLI; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, EPH FAMILY; RECOMBINANT PROTEINS; THERMODYNAMICS;

EID: 84879659750     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20130028     Document Type: Article

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