Effect of quercetin on the toxicokinetics of ochratoxin A in rats

Food Additives and Contaminants - Part A

Volumn 30, Issue 5, 2013, Pages 861-866

  Abbas, Zein ^a   Blank, Ralf ^a   Wein, Silvia ^a   Wolffram, Siegfried ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

multi drug resistance associated protein (MRP2); Ochratoxin A; quercetin; toxicokinetic

Indexed keywords

ANTHROPOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; PHENOLS; PROTEINS; RATS; TISSUE; TISSUE ENGINEERING;

BREAST CANCER RESISTANCE PROTEINS; COMPETITIVE INHIBITION; EFFLUX PUMP INHIBITORS; MULTIDRUG RESISTANCE; MYCOTOXIN OCHRATOXIN A; OCHRATOXIN A; QUERCETIN; TOXICOKINETICS;

FLAVONOIDS;

BREAST CANCER RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; OCHRATOXIN; QUERCETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DIET THERAPY; FECES ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; KIDNEY PARENCHYMA; LIMIT OF DETECTION; LIVER; MALE; MUSCLE TISSUE; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; TOXICOKINETICS; URINALYSIS; URINARY EXCRETION; WEIGHT GAIN;

ANIMALIA; RATTUS; TRITICUM AESTIVUM;

EID: 84879639600     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2013.793823     Document Type: Article

References (35)

1. Adler M, Müller K, Rached E, Dekant W, Mally A. 2009. Modulation of key regulators of mitosis linked to chromosomal instability is an early event in Ochratoxin A carcinogenicity. Carcinogenesis. 30:711-719.
2. Aherne SA, O'Brien NM. 2002. Dietary flavonols: chemistry, food content, and metabolism. Nutrition. 18:75-81.
3. Berger V, Gabriel AF, Sergent T, Trouet A, Larondelle Y, Schneider YJ. 2002. Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2). Toxicol Lett. 140-141:465-476.
4. Blank R, Rolfs JP, Südekum KH, Frohlich AA, Marquardt RR, Wolffram S. 2003. Effects of chronic ingestion of ochratoxin A on blood levels and excretion of the mycotoxin in sheep. J Agric Food Chem. 51:6899-6905.
5. Bock KW, Eckle T, Ouzzine M, Fournel-Gigleux S. 2000. Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 Cells. Biochem Pharmacol. 59:467-470.
6. Castegnaro M, Mohr U, Pfohl-Leszkowicz A, Estève J, Steinmann J, Tillmann T, Michelon J, Bartsch H. 1998. Sex- and strain-specific induction of renal tumors by Ochratoxin A in rats correlates with DNA adduction. Int J Cancer. 77:70-75.
7. Cooray HC, Jansvilisri T, van Veen HW, Hladky SB, Barrand MA. 2004. Interaction of the breast cancer resistance protein with plant polyphenols. Biochem Biophys Res Commun. 317:269-275.
8. Creppy EE, Kern D, Steyn PS, Vlegaar R, Röschenthaler R, Dirheimer G. 1983. Comparative study of the effect of ochratoxin A analogues on yeast aminoacyl-tRNA synthesis and on the growth and protein synthesis of hepatoma cells. Toxicol Lett. 19:217-224.
9. Di Giacomo C, Acquaviva R, Piva A, Sorrenti V, Vanella L, Piva G, Casadei G, La Fauci L, Ritieni A, Bognanno M, et al. 2007. Protective effect of cyanidin 3-O-β-d-glucoside on ochratoxin A-mediated damage in the rat. Brit J Nutr. 98:937-943.
10. Doster RC, Sinnhuber RO. 1972. Comparative rates of hydrolysis of Ochratoxins A and B in vitro. Food Cosmet Toxicol. 10:389-394.
11. Ebert B, Seidel A, Lampen A. 2007. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 96:227-236.
12. Ferrufino-Guardia EV, Tangni EK, Larondelle Y, Ponchaut S. 2000. Transfer of ochratoxin A during lactation: exposure of sucling via milk of rabbit does fed a naturally contamined feed. Food Addit Contam. 17:167-175.
13. Galtier P. 1978. Contribution of pharmacokinetic studies to mycotoxicology - Ochratoxin A. Vet Sci Commun. 1:349-358.
14. Gekle M, Oberleithner H, Silbernagl S. 1993. Ochratoxin A impairs "postproximal" nephron function in vivo and blocks plasma membrane anion conductance in Madin-Darby canine kidney cells in vitro. Pflügers Arch. 425:401-408.
15. Harwing J, Kuiper-Goodman T, Scott PM. 1983. Microbial food toxicant: ochratoxins. In: Rechcigl M, editor. Handbook of foodborne diseases of biological origin. Boca Raton, FL: CRC Press; p. 192-238.
16. Kumagai S, Aibara K. 1982. Intestinal absorption and secretion of ochratoxin A in the rat. Toxicol Appl Pharmacol. 64: 94-102.
17. Leier I, Hummel-Eisenbeiss J, Cui Y, Keppler D. 2000. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 57:1636-1642.
18. Madhyastha MS, Marquardt RR, Frohlich AA. 1992. Hydrolysis of ochratoxin A by the micorbial activity of digesta in the gastrointestinal tracts of rats. Arch Environ Contam Toxicol. 23:468-472.
19. Mally A, Völkel W, Amberg A, Kurz M, Wanek P, Eder E, Hard G, Dekant W. 2005. Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats. Chem Res Toxicol. 18:1242-1252.
20. Mantle PG. 2008. Interpretation of the pharmacokinetics of ochratoxin A in blood plasma of rats, during and after acute or chronic ingestion. Food Chem Toxicol. 46:1808-1816.
21. Meki AMA, Hussein AAA. 2001. Melatonin reduces oxidative stress induced by ochratoxin A in rat liver and kidney. Comp Biochem Physiol C. 130:305-313.
22. Middleton Jr E, Kandaswami C, Theoharides T. 2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev. 52:673-751.
23. National Toxicology Program. 1989. Technical report on the toxicology and carcinogenesis studies of ochratoxin A (CAS No. 303-47-9) in F344 rats (Gavage Studies), NIH Publication No. 89-2813. Research Triangle Park, NC: US Department of Health and Human Services, National Institutes of Health.
24. O'Leary KA, Day AJ, Needs PW, Mellon FA, O'Brien NM, Williamson G. 2003. Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochem Pharmacol. 65:479-491.
25. Omar RF, Hasinoff BB, Mejilla F, Rahimtula AD. 1990. Mechanism of ochratixin A stimulated lipid peroxidation. Biochem Pharmacol. 40:1183-1191.
26. Peraica M, Domijan A-M, Miletić-Medved M, Fuchs R. 2008. The involvement of mycotoxins in the development of endemic nephropathy. Wien Klin Wochenschr. 120:402-407.
27. Schrickx J, Lektarau Y, Fink-Gremmels J. 2006. Ochratoxin A secretion by ATP dependent membrane transporters in Caco-2 cells. Arch Toxicol. 80:243-249.
28. Sergent T, Garsou S, Schaut A, De Saeger S, Pussemier L, Van Peteghem C, Larondelle Y, Schneider YJ. 2005. Differential modulation of ochratoxin A absorption across Caco-2 cells by dietary polyphenols, used at realistic intestinal concentrations. Toxicol Lett. 159:60-70.
29. Soyoz M, Özçelik N, Kilinç I, Altuntaş I. 2004. The effects of ochratoxin A on lipid peroxidation and antioxidant enzymes: a protective role of melatonin. Cell Biol Toxicol. 20:213-219.
30. Stoev SD, Paskalev M, MacDonald S, Mantle PG. 2002. Experimental one year ochratoxin A toxicosis in pigs. Exp Toxicol Pathol. 53:481-487.
31. van der Merwe KJ, Steyn PS, Fourie L. 1965. Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature. 205:7083-7088.
32. Walgren RA, Karnaky Jr KJ, Lindenmayer GE, Walle T. 2000. Efflux of dietary flavonoid quercetin 4'-β-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2. J Pharmacol Exp Ther. 294:830-836.
33. Xiao H, Marquardt RR, Frohlich AA, Yang ZL. 1995. Synthesis and structural elucidation of analogs of ochratoxin A. J Agric Food Chem. 43:524-530.
34. Zepnik H, Völkel W, Dekant W. 2003. Toxicokinetics of the mycotoxin ochratoxin A in F344 rats after oral administration. Toxicol Appl Pharmacol. 192:36-44.
35. Zhang S, Yang X, Morris ME. 2004. Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol. 65:1208-1216.