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Volumn 12, Issue 3, 2007, Pages 205-212

Greater inhibition of platelet aggregation and reduced response variability with prasugrel versus clopidogrel: An integrated analysis

Author keywords

ADP; Clopidogrel; P2Y12; Platelet aggregation; Prasugrel; Resistance; Thienopyridines

Indexed keywords

ADENOSINE DIPHOSPHATE; CLOPIDOGREL; PRASUGREL;

EID: 34548151179     PISSN: 10742484     EISSN: None     Source Type: Journal    
DOI: 10.1177/1074248407304731     Document Type: Article
Times cited : (33)

References (33)
  • 1
    • 33744999455 scopus 로고    scopus 로고
    • Biology and pharmacology of the platelet P2Y12 receptor
    • Storey RF Biology and pharmacology of the platelet P2Y12 receptor. Curr Pharm Des. 2006 ; 12: 1255-1259.
    • (2006) Curr Pharm des , vol.12 , pp. 1255-1259
    • Storey, R.F.1
  • 2
    • 0038354521 scopus 로고    scopus 로고
    • Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation
    • Barragan P., Bouvier JL, Roquebert PO, et al. Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv. 2003 ; 59: 295-302.
    • (2003) Catheter Cardiovasc Interv , vol.59 , pp. 295-302
    • Barragan, P.1    Bouvier, J.L.2    Roquebert, P.O.3
  • 3
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, O'Connor CM Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation. 2003 ; 107: 2908-2913.
    • (2003) Circulation , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Kp, B.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 4
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    • Lau WC, Gurbel PA, Watkins PB, et al. Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation. 2004 ; 109: 166-171.
    • (2004) Circulation , vol.109 , pp. 166-171
    • Lau, W.C.1    Gurbel, P.A.2    Watkins, P.B.3
  • 5
    • 11144357878 scopus 로고    scopus 로고
    • Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions
    • Lepantalo A., Virtanen KS, Heikkila J., Wartiovaara U., Lassila R. Limited early antiplatelet effect of 300 mg clopidogrel in patients with aspirin therapy undergoing percutaneous coronary interventions. Eur Heart J. 2004 ; 25: 476-483.
    • (2004) Eur Heart J. , vol.25 , pp. 476-483
    • Lepantalo, A.1    Virtanen, K.S.2    Heikkila, J.3    Wartiovaara, U.4    Lassila, R.5
  • 6
    • 9644281092 scopus 로고    scopus 로고
    • Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting
    • Angiolillo DJ, Fernandez-Ortiz A., Bernardo E., et al. Identification of low responders to a 300-mg clopidogrel loading dose in patients undergoing coronary stenting. Thromb Res. 2005 ; 115: 101-108.
    • (2005) Thromb Res. , vol.115 , pp. 101-108
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 7
    • 27744516843 scopus 로고    scopus 로고
    • Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial
    • Von Beckerath N., Taubert D., Pogatsa-Murray G., Schomig E., Kastrati A., Schomig A. Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation. 2005 ; 112: 2946-2950.
    • (2005) Circulation. , vol.112 , pp. 2946-2950
    • Von Beckerath, N.1    Taubert, D.2    Pogatsa-Murray, G.3    Schomig, E.4    Kastrati, A.5    Schomig, A.6
  • 8
    • 19644372173 scopus 로고    scopus 로고
    • Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention
    • Hochholzer W., Trenk D., Frundi D., et al. Time dependence of platelet inhibition after a 600-mg loading dose of clopidogrel in a large, unselected cohort of candidates for percutaneous coronary intervention. Circulation. 2005 ; 111: 2560-2564.
    • (2005) Circulation , vol.111 , pp. 2560-2564
    • Hochholzer, W.1    Trenk, D.2    Frundi, D.3
  • 9
    • 33745167304 scopus 로고    scopus 로고
    • Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy
    • Smith SM, Judge HM, Peters G., et al. Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy. Platelets. 2006 ; 17: 250-258.
    • (2006) Platelets. , vol.17 , pp. 250-258
    • Smith, S.M.1    Judge, H.M.2    Peters, G.3
  • 10
    • 0038291914 scopus 로고    scopus 로고
    • Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement
    • Muller I., Besta F., Schulz C., Massberg S., Schomig A., Gawaz M. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb Haemost. 2003 ; 89: 783-787.
    • (2003) Thromb Haemost. , vol.89 , pp. 783-787
    • Muller, I.1    Besta, F.2    Schulz, C.3    Massberg, S.4    Schomig, A.5    Gawaz, M.6
  • 11
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • Matetzky S., Shenkman B., Guetta V., et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation. 2004 ; 109: 3171-3175.
    • (2004) Circulation , vol.109 , pp. 3171-3175
    • Matetzky, S.1    Shenkman, B.2    Guetta, V.3
  • 12
    • 33750479499 scopus 로고    scopus 로고
    • Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement
    • Hochholzer W., Trenk D., Bestehorn HP, et al. Impact of the degree of peri-interventional platelet inhibition after loading with clopidogrel on early clinical outcome of elective coronary stent placement. J Am Coll Cardiol. 2006 ; 48: 1742-1750.
    • (2006) J Am Coll Cardiol. , vol.48 , pp. 1742-1750
    • Hochholzer, W.1    Trenk, D.2    Bestehorn, H.P.3
  • 13
    • 33645982865 scopus 로고    scopus 로고
    • High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome
    • Cuisset T., Frere C., Quilici J., et al. High post-treatment platelet reactivity identified low-responders to dual antiplatelet therapy at increased risk of recurrent cardiovascular events after stenting for acute coronary syndrome. J Thromb Haemost. 2006 ; 4: 542-549.
    • (2006) J Thromb Haemost. , vol.4 , pp. 542-549
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 14
    • 21644448736 scopus 로고    scopus 로고
    • Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: Results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial
    • Wiviott SD, Antman EM, Winters KJ, et al. Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial. Circulation. 2005 ; 111: 3366-3373.
    • (2005) Circulation , vol.111 , pp. 3366-3373
    • Wiviott, S.D.1    Antman, E.M.2    Winters, K.J.3
  • 15
    • 33748680917 scopus 로고    scopus 로고
    • Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: Design and rationale for the Trial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38)
    • Wiviott SD, Antman EM, Gibson CM, et al. Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the Trial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38). Am Heart J. 2006 ; 152: 627-635.
    • (2006) Am Heart J. , vol.152 , pp. 627-635
    • Wiviott, S.D.1    Antman, E.M.2    Gibson, C.M.3
  • 16
    • 0034068625 scopus 로고    scopus 로고
    • The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties
    • Sugidachi A., Asai F., Ogawa T., et al. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br J Pharmacol. 2000 ; 129: 1439-1446.
    • (2000) Br J Pharmacol. , vol.129 , pp. 1439-1446
    • Sugidachi, A.1    Asai, F.2    Ogawa, T.3
  • 17
    • 33745699564 scopus 로고    scopus 로고
    • The platelet inhibitory effects and pharmacokinetics of prasugrel after administration of loading and maintenance doses in healthy subjects
    • Jakubowksi JA, Payne CD, Brandt JT, et al. The platelet inhibitory effects and pharmacokinetics of prasugrel after administration of loading and maintenance doses in healthy subjects. J Cardiovasc Pharmacol. 2006 ; 47: 377-384.
    • (2006) J Cardiovasc Pharmacol. , vol.47 , pp. 377-384
    • Jakubowksi, J.A.1    Payne, C.D.2    Brandt, J.T.3
  • 18
    • 33947284488 scopus 로고    scopus 로고
    • A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans
    • Jakubowski JA, Matsushima N., Asai F., et al. A multiple dose study of prasugrel (CS-747), a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy humans. Br J Clin Pharmacol. 2007 ; 63: 421-430.
    • (2007) Br J Clin Pharmacol. , vol.63 , pp. 421-430
    • Jakubowski, J.A.1    Matsushima, N.2    Asai, F.3
  • 19
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite
    • Brandt JT, Payne CD, Wiviott SD, et al. A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite. Am Heart J. 2007 ; 153 :66.e9-16.
    • (2007) Am Heart J. , vol.153
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3
  • 20
    • 0028083293 scopus 로고    scopus 로고
    • The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A
    • Savi P., Combalbert J., Gaich C., et al. The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A. Thromb Haemost. 2006 ; 72: 313-317.
    • (2006) Thromb Haemost. , vol.72 , pp. 313-317
    • Savi, P.1    Combalbert, J.2    Gaich, C.3
  • 21
    • 33645105318 scopus 로고    scopus 로고
    • Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450
    • Rehmel JL, Eckstein JA, Farid NA, et al. Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450. Drug Metab Dispos. 2006 ; 34: 600-607.
    • (2006) Drug Metab Dispos. , vol.34 , pp. 600-607
    • Rehmel, J.L.1    Eckstein, J.A.2    Farid, N.A.3
  • 23
    • 33646732608 scopus 로고    scopus 로고
    • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
    • Jernberg T., Payne CD, Winters KJ, et al. Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J. 2006 ; 27: 1166-1173.
    • (2006) Eur Heart J. , vol.27 , pp. 1166-1173
    • Jernberg, T.1    Payne, C.D.2    Winters, K.J.3
  • 24
    • 19644370822 scopus 로고    scopus 로고
    • Loading, pretreatment, and interindividual variability issues with clopidogrel dosing
    • Bates ER, Lau WC, Bleske BE Loading, pretreatment, and interindividual variability issues with clopidogrel dosing. Circulation. 2005 ; 111: 2557-2559.
    • (2005) Circulation , vol.111 , pp. 2557-2559
    • Bates, E.R.1    Lau, W.C.2    Bleske, B.E.3
  • 26
    • 34247256797 scopus 로고    scopus 로고
    • Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently
    • Farid NA, Payne CD, Small DS, et al. Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clin Pharmacol Ther. 2007 ; 81: 735-741.
    • (2007) Clin Pharmacol Ther. , vol.81 , pp. 735-741
    • Farid, N.A.1    Payne, C.D.2    Small, D.S.3
  • 27
    • 27644465874 scopus 로고    scopus 로고
    • Clopidogrel effect on platelet reactivity in patients with stent thrombosis: Results of the CREST Study
    • Gurbel PA, Bliden KP, Samara W., et al. Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study. J Am Coll Cardiol. 2005 ; 46: 1827-1832.
    • (2005) J Am Coll Cardiol. , vol.46 , pp. 1827-1832
    • Gurbel, P.A.1    Kp, B.2    Samara, W.3
  • 28
    • 0034762075 scopus 로고    scopus 로고
    • Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement
    • Muller I., Seyfarth M., Rudiger S., et al. Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement. Heart. 2001 ; 85: 92-93.
    • (2001) Heart , vol.85 , pp. 92-93
    • Muller, I.1    Seyfarth, M.2    Rudiger, S.3
  • 29
    • 14944378655 scopus 로고    scopus 로고
    • Clopidogrel loading with eptifibatide to arrest the reactivity of platelets-Results of the clopidogrel loading with eptifibatide to arrest the reactivity of platelets (CLEAR PLATELETS) study
    • Gurbel PA, Bliden KP, Zaman KA, Yoho JA, Hayes KM, Tantry US Clopidogrel loading with eptifibatide to arrest the reactivity of platelets-Results of the clopidogrel loading with eptifibatide to arrest the reactivity of platelets (CLEAR PLATELETS) study. Circulation. 2005 ; 111: 1153-1159.
    • (2005) Circulation , vol.111 , pp. 1153-1159
    • Gurbel, P.A.1    Kp, B.2    Zaman, K.A.3    Yoho, J.A.4    Hayes, K.M.5    Tantry, U.S.6
  • 30
    • 18144371221 scopus 로고    scopus 로고
    • The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting
    • Gurbel PA, Bliden KP, Hayes KM, Yoho JA, Herzog WR, Tantry US The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol. 2005 ; 45: 1392-1396.
    • (2005) J Am Coll Cardiol. , vol.45 , pp. 1392-1396
    • Gurbel, P.A.1    Kp, B.2    Hayes, K.M.3    Yoho, J.A.4    Herzog, W.R.5    Tantry, U.S.6
  • 31
    • 33747874088 scopus 로고    scopus 로고
    • A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: The ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial
    • Montalescot G., Sideris G., Meuleman C., et al. A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial. J Am Coll Cardiol. 2006 ; 48: 931-938.
    • (2006) J Am Coll Cardiol. , vol.48 , pp. 931-938
    • Montalescot, G.1    Sideris, G.2    Meuleman, C.3
  • 32
    • 36348977461 scopus 로고    scopus 로고
    • Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel
    • Payne CD, Li YG, Small DS, et al. Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel. J Cardiovasc Pharmacol. (In press).
    • J Cardiovasc Pharmacol
    • Payne, C.D.1    Li, Y.G.2    Small, D.S.3
  • 33
    • 34147207681 scopus 로고    scopus 로고
    • Dose-dependent inhibition of platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects
    • Jakubowski JA, Payne CD, Weerakkoddy GJ, et al. Dose-dependent inhibition of platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects. J Cardiovasc Pharmacol. 2007 ; 49: 167-173.
    • (2007) J Cardiovasc Pharmacol. , vol.49 , pp. 167-173
    • Jakubowski, J.A.1    Payne, C.D.2    Weerakkoddy, G.J.3


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