A core-shell albumin copolymer nanotransporter for high capacity loading and two-step release of doxorubicin with enhanced anti-leukemia activity

Advanced Healthcare Materials

Volumn 2, Issue 6, 2013, Pages 884-894

  Wu, Yuzhou ^a,b   Ihme, Susann ^c   Feuring Buske, Michaela ^c,d   Kuan, Seah Ling ^a   Eisele, Klaus ^a   Lamla, Markus ^a   Wang, Yanran ^a   Buske, Christian ^c   Weil, Tanja ^a,b  

^a Institute of Organic Chemistry III Macromolecular Chemistry   (Germany)

^b MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

^c Department of Internal Medicine III   (Germany)

^d UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Albumin; Doxorubicin; Leukemia; Nanomedicine; Two step release

Indexed keywords

BIOCOMPATIBILITY; CARDIOVASCULAR SYSTEM; CELL CULTURE; DISEASES; DRUG DOSAGE; MEDICAL NANOTECHNOLOGY; MICELLES; MOLECULES; PROTEINS; SHELLS (STRUCTURES); TARGETED DRUG DELIVERY;

ALBUMIN; DOXORUBICIN; DRUG DELIVERY APPLICATIONS; DRUG RELEASE MECHANISM; LEUKEMIA; NARROW SIZE DISTRIBUTIONS; POLYPEPTIDE BACKBONES; TWO-STEP RELEASE;

CONTROLLED DRUG DELIVERY;

CARRIER PROTEIN; CASPASE 3; CASPASE 7; CATION; COPOLYMER; DOXORUBICIN; EPITOPE; NANOSHELL; SERUM ALBUMIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CANCER CELL CULTURE; CELL SURVIVAL; CELL VIABILITY; CHEMICAL STRUCTURE; CIRCULATION; CIRCULATION TIME; CONTROLLED STUDY; COVALENT BOND; CYTOSOL; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; ENCAPSULATION; ENDOSOME; ENGRAFTMENT; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; HYDRODYNAMICS; IC 50; IN VITRO STUDY; LEUKEMIA CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEMBRANE DAMAGE; MICELLE; NANOMEDICINE; PARTICLE SIZE; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

EID: 84879608525     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201200296     Document Type: Article

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