ATP-binding cassette transporter G1 protects against endothelial dysfunction induced by high glucose

Diabetes Research and Clinical Practice

Volumn 101, Issue 1, 2013, Pages 72-80

  Xue, Jiahong ^a   Wang, Congxia ^a   Zhu, Canzhan ^a   Li, Yongqin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

ABCG1; ATP binding cassette transporter G1; BSA; Cholesterol efflux; Endothelial dysfunction; ENOS; HAECs; HDL; High glucose; ICAM; LXR; NOS; Oxidative stress; ROS

Indexed keywords

ABC TRANSPORTER G1; GLUCOSE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; ABC TRANSPORTER; ABCG1 PROTEIN, HUMAN; CHOLESTEROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NOS3 PROTEIN, HUMAN; PROTECTIVE AGENT; SWEETENING AGENT;

AORTA; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GAS LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA INTERFERENCE; SCINTILLATION; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL; VASCULAR ENDOTHELIUM;

ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELLS, CULTURED; CHOLESTEROL; ENDOTHELIUM, VASCULAR; GLUCOSE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; NITRIC OXIDE SYNTHASE TYPE III; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWEETENING AGENTS;

EID: 84879606929     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2013.04.009     Document Type: Article

References (33)

1. Hansson G.K. Inflammation atherosclerosis and coronary artery disease. N Engl J Med 2005, 352:1685-1695.
2. Widlansky M.E., Gokce N., Keaney J.F., Vita J.A. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003, 42:1149-1160.
3. Zeiher A.M., Drexler H., Wollschlager H., Just H. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 1991, 83:391-401.
4. Rodríguez-Mañas L., Angulo J., Vallejo S., Peiró C., Sánchez-Ferrer A., Cercas E., et al. Early and intermediate amadori glycosylation adducts, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature. Diabetologia 2003, 46:556-566.
5. Calles-Escandon J., Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 2001, 22:36-52.
6. Giugliano D., Ceriello A., Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 1996, 19:257-267.
7. Cai H., Harrison D.G. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000, 87:840-844.
8. Rabinovitch A. An update on cytokines in the pathogenesis of insulin dependent diabetes mellitus. Diabetes Metab Rev 1998, 14:129-151.
9. Vaughan A.M., Oram J.F. ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. J Lipid Res 2006, 47:2433-2446.
10. Wang N., Lan D., Chen W., Matsuura F., Tall A.R. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci USA 2004, 101:9774-9779.
11. O'Connell B.J., Denis M., Genest J. Cellular physiology of cholesterol efflux in vascular endothelial cells. Circulation 2004, 110:2881-2888.
12. Terasaka N., Yu S., Yvan-Charvet L., Wang N., Mzhavia N., Langlois Pagler T., et al. ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest 2008, 118:3701-3713.
13. Fielding P.E., Davison P.M., Karasek M.A., Fielding C.J. Regulation of sterol transport in human microvascular endothelial cells. J Cell Biol 1982, 94:350-354.
14. Xue J.H., Yuan Z., Wu Y., Liu Y., Zhao Y., Zhang W.P., et al. High glucose promotes intracellular lipid accumulation in vascular smooth muscle cells by impairing cholesterol influx and efflux balance. Cardiovasc Res 2010, 85:141-150.
15. Mauldin J.P., Srinivasan S., Mulya A., Gebre A., Parks J.S., Daugherty A., et al. Reduction in ABCG1 in type 2 diabetic mice increases macrophage foam cell formation. J Biol Chem 2006, 281:21216-21224.
16. Mauldin J.P., Nagelin M.H., Wojcik A.J., Srinivasan S., Skaflen M.D., Ayers C.R., et al. Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus. Circulation 2008, 117:2785-2792.
17. Rudel L.L., Kelley K., Sawyer J.K., Shah R., Wilson M.D. Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human ApoB100-overexpressing transgenic mice. Arterioscler Thromb Vasc Biol 1998, 18:1818-1827.
18. Robbesyn F., Garcia V., Auge N., Vieira O., Frisach M.F., Salvayre R., et al. HDL counterbalance the proinflammatory effect of oxidized LDL by inhibiting intracellular reactive oxygen species rise, proteasome activation, and subsequent NF-kappaB activation in smooth muscle cells. FASEB J 2003, 17:743-745.
19. Xue J., Niu X., Wei J., Dong X., Zhu C., Dang Y., et al. Endothelial dysfunction induced by high glucose is associated with decreased ATP-binding cassette transporter G1 expression. Nan Fang Yi Ke Da Xue Xue Bao 2012, 32:14-18. [in Chinese].
20. Whetzel A.M., Sturek J.M., Nagelin M.H., Bolick D.T., Gebre A.K., Parks J.S., et al. ABCG1 deficiency in mice promotes endothelial activation and monocyte-endothelial interactions. Arterioscler Thromb Vasc Biol 2010, 30:809-817.
21. Pennings M. Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development. FEBS Lett 2006, 580:5588-5596.
22. Srinivasan S., Hatley M.E., Bolick D.T., Palmer L.A., Edelstein D., Brownlee M., et al. Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells. Diabetologia 2004, 47:1727-1734.
23. Rohrer L., Ohnsorg P.M., Lehner M., Landolt F., Rinninger F., von Eckardstein A. High-density lipoprotein transport through aortic endothelial cells involves scavenger receptor BI and ATP-binding cassette transporter G1. Circ Res 2009, 104:1142-1150.
24. Terasaka N., Westerterp M., Koetsveld J., Fernández-Hernando C., Yvan-Charvet L., Wang N., et al. ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase. Arterioscler Thromb Vasc Biol 2010, 30:2219-2225.
25. Li D., Zhang Y., Ma J., Ling W., Xia M. Adenosine monophosphate activated protein kinase regulates ABCG1-mediated oxysterol efflux from endothelial cells and protects against hypercholesterolemia induced endothelial dysfunction. Arterioscler Thromb Vasc Biol 2010, 30:1354-1362.
26. Terasaka N., Hiroshima A., Koieyama T., Ubukata N., Morikawa Y., Nakai D., et al. T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. FEBS Lett 2003, 536:6-11.
27. Schultz J.R., Tu H., Luk A., Repa J.J., Medina J.C., Li L., et al. Role of LXRs in control of lipogenesis. Genes Dev 2000, 14:2831-2838.
28. Naik S.U., Wang X., Da Silva J.S., Jaye M., Macphee C.H., Reilly M.P., et al. Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation 2006, 113:90-97.
29. Baldán E.Á., Gomes A.V., Ping P.P., Peter A. Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol 2008, 180:3560-3568.
30. Wojcik A.J., Skaflen M.D., Srinivasan S., Hedrick C.C. A critical role for ABCG1 in macrophage inflammation and lung homeostasis. J Immunol 2008, 180:4273-4282.
31. Yvan-Charvet L., Welch C., Pagler T.A., Ranalletta M., Lamkanfi M., Han S., et al. Increased inflammatory gene expression in ABC transporter deficient macrophages: free cholesterol accumulation, increased signaling via Toll-like receptors and neutrophil infiltration of atherosclerotic lesions. Circulation 2008, 118:1837-1847.
32. Molnar J., Yu S., Mzhavia N., Pau C., Chereshnev I., Dansky H.M. Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice. Circ Res 2005, 96:1178-1184.
33. Hink U., Li H., Mollnau H., Oelze M., Matheis E., Hartmann M., et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001, 88:E14-E22.