HAHAHA, HEHEHE, HIHIHI, or HKHKHK: Influence of position and composition of histidine containing tags on biodistribution of [99mTc(CO) 3]+-labeled affibody molecules

Journal of Medicinal Chemistry

Volumn 56, Issue 12, 2013, Pages 4966-4974

  Hofström, Camilla ^a   Altai, Mohamed ^b   Honarvar, Hadis ^b   Strand, Joanna ^b   Malmberg, Jennie ^c   Hosseinimehr, Seyed Jalal ^b,d   Orlova, Anna ^c   Gräslund, Torbjörn ^a   Tolmachev, Vladimir ^b  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HISTIDINE DERIVATIVE; METAL ION; RADIOISOTOPE; TECHNETIUM 99M;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG RETENTION; DRUG STRUCTURE; DRUG UPTAKE; FEMALE; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY; LABELING INDEX; LIPOPHILICITY; MOLECULAR IMAGING; MOUSE; NONHUMAN; RADIOACTIVITY;

ANIMALS; CELL LINE, TUMOR; DRUG STABILITY; FEMALE; HISTIDINE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISOTOPE LABELING; KINETICS; MICE; ORGANOTECHNETIUM COMPOUNDS; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS; TISSUE DISTRIBUTION;

EID: 84879575076     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400218y     Document Type: Article

References (33)

1. Sharma, P. S.; Sharma, R.; Tyagi, T. Receptor tyrosine kinase inhibitors as potent weapons in war against cancers Curr. Pharm. Des. 2009, 15, 758-776
2. Tolmachev, V.; Stone-Elander, S.; Orlova, A. Current approaches to the use of radiolabeled tyrosine kinase-targeting drugs for patient stratification and treatment response monitoring: prospects and pitfalls Lancet Oncol. 2010, 11, 992-1000
3. Löfblom, J.; Feldwisch, J.; Tolmachev, V.; Carlsson, J.; StaÌŠhl, S.; Frejd, F. Y. Affibody molecules: engineered proteins for therapeutic, diagnostic and biotechnological applications FEBS Lett. 2010, 584, 2670-2680
4. Orlova, A.; Magnusson, M.; Eriksson, T. L.; Nilsson, M.; Larsson, B.; Höiden-Guthenberg, I.; Widström, C.; Carlsson, J.; Tolmachev, V.; StaÌŠhl, S.; Nilsson, F. Y. Tumor imaging using a picomolar affinity HER2 binding affibody molecule Cancer Res. 2006, 66, 4339-4348
5. EGFR:2377 affibody molecule: aspect of the injected tracer amount Eur. J. Nucl. Med. Mol. Imaging 2010, 37, 613-622
6. Kronqvist, N.; Malm, M.; Göstring, L.; Gunneriusson, E.; Nilsson, M.; Höiden-Guthenberg, I.; Gedda, L.; Frejd, F. Y.; StaÌŠhl, S.; Löfblom, J. Combining phage and staphylococcal surface display for generation of ErbB3-specific affibody molecules Protein Eng., Des. Sel. 2010, 24, 385-396
7. Lindborg, M.; Cortez, E.; Höiden-Guthenberg, I.; Gunneriusson, E.; von Hage, E.; Syud, F.; Morrison, M.; Abrahmsén, L.; Herne, N.; Pietras, K.; Frejd, F. Y. Engineered high-affinity affibody molecules targeting platelet-derived growth factor receptor beta in vivo J. Mol. Biol. 2011, 407, 298-315
8. IGF1R:4551 J. Nucl. Med. 2012, 53, 90-97
9. Ahlgren, S.; Tolmachev, V. Radionuclide molecular imaging using affibody molecules Curr. Pharm. Biotechnol. 2010, 11, 581-589
10. 68Ga-labeled affibody molecules J. Nucl. Med. 2010, 51, 892-897
11. 111In]ABY-025 metastatic detection capability in females with metastatic breast cancer J. Nucl. Med. 2012, 53 (Suppl1) 220
12. Tolmachev, V.; Orlova, A. Influence of labeling methods on biodistribution and imaging properties of radiolabelled peptides for visualization of molecular therapeutic targets Curr. Med. Chem. 2010, 17, 2636-2655
13. Núñez, R.; Erwin, W. D.; Wendt, R. E.; Stachowiak, A.; Mar, M.; Stevens, D.; Madewell, J. E.; Yeung, H. W.; Macapinlac, H. A. Acquisition parameters for oncologic imaging with a new SPECT/multislice CT scanner Mol. Imaging Biol. 2010, 2, 110-138
14. Orlova, A.; Nilsson, F. Y.; Wikman, M.; Widström, C.; StaÌŠhl, S.; Carlsson, J.; Tolmachev, V. Comparative in vivo evaluation of technetium and iodine labels on an anti-HER2 affibody for single-photon imaging of HER2 expression in tumors J. Nucl. Med. 2006, 47, 512-519
15. Tran, T. A.; Rosik, D.; Abrahmsén, L.; Sandström, M.; Sjöberg, A.; WaÌŠllberg, H.; Ahlgren, S.; Orlova, A.; Tolmachev, V. Design, synthesis and biological evaluation of a HER2-specific affibody molecule for molecular imaging Eur. J. Nucl. Med. Mol. Imaging 2009, 36, 1864-1873
16. 99mTc-labeled recombinant affibody molecules improves their biodistribution and imaging properties J. Nucl. Med. 2011, 52, 461-469
17. 99mTc-labeled recombinant affibody molecules Amino Acids 2012, 42, 1975-1985
18. Waibel, R.; Alberto, R.; Willuda, J.; Finnern, R.; Schibli, R.; Stichelberger, A.; Egli, A.; Abram, U.; Mach, J. P.; Plücthun, A.; Schubiger, P. A. Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex Nature Biotechnol. 1999, 17, 897-901
19. Novak-Hofer, I.; Waibel, R.; Zimmermann, K.; Schibli, R.; Grünberg, J.; Chester, K. A.; Murray, A.; Lo, B. K.; Perkins, A. C.; Schubiger, P. A. Radiometal labeling of antibodies and antibody fragments for imaging and therapy Methods Mol. Biol. 2004, 248, 481-494
20. + and show improved biodistribution Bioconjugate Chem. 2010, 21, 2013-2022
21. Hopp, T. P.; Woods, K. R. Prediction of protein antigenic determinants from amino acid sequence Proc. Natl. Acad. Sci. U. S. A. 1982, 78, 3824-3828
22. Kyte, J.; Doolittle, R. F. A simple method for displaying the hydropathic character of a protein J. Mol. Biol. 1982, 157, 105-132
23. Ahlgren, S.; Orlova, A.; Rosik, D.; Sandström, M.; Sjöberg, A.; Baastrup, B.; Widmark, O.; Fant, G.; Feldwisch, J.; Tolmachev, V. Evaluation of maleimide derivative of DOTA for site-specific labeling of recombinant affibody molecules Bioconjugate Chem. 2008, 19, 235-243
24. HER2:2395, with C-terminally engineered cysteine J. Nucl. Med. 2009, 50, 781-789
25. (125)I J. Med. Chem. 2011, 54, 3817-3826
26. IGF1R:4551, a new affibody conjugate for visualization of insulin-like growth factor-1 receptor expression in malignant tumours Eur. J. Nucl. Med. Mol. Imaging 2013, 40, 439-449
27. Hosseinimehr, S. J.; Tolmachev, V.; Orlova, A. Liver uptake of radiolabeled targeting proteins and peptides: considerations for targeting peptide conjugate design Drug Discovery Today 2012, 17, 1224-1232
28. 99mTc-Labeled anti-HER2 Affibody Molecules Bioconjugate Chem. 2008, 19, 2568-2576
29. (99m)Tc labeled to a peptide by 4 methods J. Nucl. Med. 2001, 42, 1870-1877
30. Tolmachev, V.; Tran, T. A.; Rosik, D.; Sjöberg, A.; Abrahmsén, L.; Orlova, A. Tumor targeting using affibody molecules: interplay of affinity, target expression level, and binding site composition J. Nucl. Med. 2012, 53, 953-960
31. + Eur. J. Nucl. Med. Mol Imaging 2012, 39 (Suppl2) S216
32. Miao, Z.; Levi, J.; Cheng, Z. Protein scaffold-based molecular probes for cancer molecular imaging Amino Acids 2011, 41, 1037-1047
33. Nelson, D. L.; Cox, M. M. Lehninger Principles of Biochemistry, 5th ed.; W. H. Freeman and Company: New York, 2008.