Triterpenoid pristimerin induced HepG2 cells apoptosis through ROS-mediated mitochondrial dysfunction

Journal of B.U.ON.

Volumn 18, Issue 2, 2013, Pages 477-485

  Guo, Yan ^a   Zhang, Wei ^a,b   Yan, Yan Yan ^c   Ma, Cun Gen ^c   Wang, Xia ^a   Wang, Chen ^a   Zhao, Jia Li ^a  

^a Wuhai Municipal People's Hospital   (China)

^b BAOTOU MEDICAL COLLEGE   (China)

^c SHANXI DATONG UNIVERSITY   (China)

Author keywords

bcl 2 apoptosis; Hepatocellular carcinoma; HepG2; Pristimerin; ROS

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; PRISTIMERIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN ANALYSIS;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA, LIVER; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRITERPENES;

EID: 84879571791     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Kew MC. Epidemiology of hepatocellular carcinoma. Toxicology 2002;181-182:35-38. (Pubitemid 36015669)
2. Chau GY, Lui WY, Tsay SH, Chao Y, King KL, Wu CW. Postresectional adjuvant intraportal chemotherapy in patients with hepatocellular carcinoma: A case-control study. Ann Surg Oncol 2006;13:1329-1337. (Pubitemid 44435799)
3. Lo CM, Liu CL, Chan SC et al. A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma. Ann Surg 2007;245:831-842. (Pubitemid 46809282)
4. Gao JM, Wu WJ, Zhang JW, Konishi Y. The dihydro-beta-agarofuran sesquiterpenoids. Nat Prod Rep 2007;24:1153-1189.
5. Brinker AM, Ma J, Lipsky PE, Raskin I. Medicinal chemistry and pharmacology of genus tripterygium (celastraceae). Phytochemistry 2007;68:732-766. (Pubitemid 46330437)
6. Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. Terpenoids: Natural inhibitors of nf-kappab signaling with anti-inflammatory and anti-cancer potential. Cell Mol Life Sci 2008;65:2979-2999.
7. Wu CC, Chan ML, Chen WY, Tsai CY, Chang FR, Wu YC. Pristimerin induces caspase-dependent apoptosis in mda-mb-231 cells via direct effects on mitochondria. Mol Cancer Ther 2005;4:1277-1285.
8. Nagase M, Oto J, Sugiyama S, Yube K, Takaishi Y, Sakato N. Apoptosis induction in hl-60 cells and inhibition of topoisomerase II by triterpene celastrol. Biosci Biotechnol Biochem 2003;67:1883-1887. (Pubitemid 39251707)
9. Wang XH, Jia DZ, Liang YJ et al. Lgf-yl-9 induces apoptosis in human epidermoid carcinoma kb cells and multidrug resistant kbv200 cells via reactive oxygen species-independent mitochondrial pathway. Cancer Lett 2007;249:256-270.
10. Yan YY, Zheng LS, Zhang X et al. Blockade of her2/neu binding to hsp90 by emodin azide methyl anthraquinone derivative induces proteasomal degradation of her2/neu. Mol Pharm 2011;8:1687-1697.
11. Yan Y, Su X, Liang Y et al. Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated bid cleavage. Mol Cancer Ther 2008;7:1688-1697.
12. Shirota O, Morita H, Takeya K, Itokawa H. Cytotoxic aromatic triterpenes from maytenus ilicifolia and maytenus chuchuhuasca. J Nat Prod 1994;57:1675-1681.
13. Chang FR, Hayashi K, Chen IH et al. Antitumor agents. Five new agarofurans, reissantins a-e, and cytotox-ic principles from reissantia buchananii. J Nat Prod 2003;66:1416-1420. (Pubitemid 37490387)
14. Zheng WE, Chen H, Yuan SF et al. Overexpression of beta iii-tubulin and survivin associated with drug resistance to docetaxel-based chemotherapy in advanced gastric cancer. J BUON 2012;17:284-290.
15. Hockenbery DM, Giedt CD, O'Neill JW, Manion MK, Banker DE. Mitochondria and apoptosis: New therapeutic targets. Adv Cancer Res 2002;85:203-242.
16. Henry-Mowatt J, Dive C, Martinou JC, James D. Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 2004;23:2850-2860. (Pubitemid 38638847)
17. Fleury C, Mignotte B, Vayssiere JL. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 2002;84:131-141. (Pubitemid 34946949)
18. Xia Z, Lundgren B, Bergstrand A, DePierre JW, Nassberger L. Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clomipramine, and citalopram and the effects on these changes by bcl-2 and bcl-x(1). Biochem Pharmacol 1999;57:1199-1208. (Pubitemid 29171696)
19. Chan WH, Wu CC, Yu JS. Curcumin inhibits uv irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermoid carcinoma a431 cells. J Cell Biochem 2003;90:327-338.
20. Byun JY, Kim MJ, Eum DY et al. Reactive oxygen species-dependent activation of bax and poly(adp-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid pristimerin in human cervical cancer cells. Mol Pharmacol 2009;76:734-744.
21. Jing X, Ueki N, Cheng J, Imanishi H, Hada T. Induction of apoptosis in hepatocellular carcinoma cell lines by emodin. Jpn J Cancer 2002;93: 874-882. (Pubitemid 35012248)
22. Chen YC, Shen SC, Lee WR et al. Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem Pharmacol 2002;64:1713-1724.
23. Mani A, Gelmann EP. The ubiquitin-proteasome pathway and its role in cancer. J Clin Oncol 2005;23:4776-4789. (Pubitemid 46224082)
24. Ciechanover A. The ubiquitin-proteasome pathway: On protein death and cell life. Embo J 1998;17:7151-7160. (Pubitemid 29002684)
25. Yang H, Landis-Piwowar KR, Lu D et al. Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells. J Cell Biochem 2008;103:234-244.