Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19221-19237

  Yang, Shaojun ^a   Jan, Yi Hua ^b   Gray, Joshua P ^c   Mishin, Vladimir ^b   Heck, Diane E ^d   Laskin, Debra L ^b   Laskin, Jeffrey D ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c U S COAST GUARD ACADEMY   (United States)

^d NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ,2-NAPHTHOQUINONE; 1 ,4-NAPHTHOQUINONE; LUNG EPITHELIAL CELLS; PHENANTHRENEQUINONE; REACTIVE OXYGEN SPECIES; SITE DIRECTED MUTAGENESIS; SUBSTRATE-BINDING SITES; TETRAHYDROBIOPTERIN;

BIOLOGICAL ORGANS; CLONING; COENZYMES; ENZYME ACTIVITY; KETONES; OXYGEN; PULMONARY DISEASES;

BINDING SITES;

1,2 NAPHTHOQUINONE; 1,4 NAPHTHOQUINONE; 2,3 DIMETHYL 1,4 NAPHTHOQUINONE; ASPARTIC ACID; BENZOQUINONE; BIPYRIDINIUM; DICOUMAROL; HERBICIDE; HISTIDINE; INDOMETACIN; MENADIONE; N ACETYLSEROTONIN; PHENANTHRENEQUINONE; PHENYLQUINONE; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SEPIAPTERIN; SEPIAPTERIN REDUCTASE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; BIOSYNTHESIS; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRESS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; EPITHELIUM CELL; LUNG ALVEOLUS EPITHELIUM; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

OXIDATIVE STRESS; QUINONE REDOX CYCLING; QUINONES; REACTIVE OXYGEN SPECIES (ROS); REDUCTASE; TETRAHYDROBIOPTERIN;

ALCOHOL OXIDOREDUCTASES; ANIMALS; BIOPTERIN; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIAL CELLS; GENETIC VECTORS; HUMANS; LUNG; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXIDATION-REDUCTION; OXIDATIVE STRESS; QUINONES; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS;

EID: 84879567436     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.402164     Document Type: Article

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