Noninvasive assessments of optic nerve neurodegeneration in transgenic mice with isolated optic neuritis

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 7, 2013, Pages 4440-4450

  Talla, Venu ^a   Yang, Cui ^b   Shaw, Gerry ^b,c   Porciatti, Vittorio ^a   Koilkonda, Rajeshwari D ^a   Guy, John ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c EnCor Biotechnology Inc   (United States)

Author keywords

Axonal degeneration; Neurodegeneration; Neurofilaments; Neuroophthalmology; Optic neuritis

Indexed keywords

MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NEUROFILAMENT PROTEIN; PHOSPHORYLATED NEUROFILAMENT HEAVY CHAIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DEMYELINATION; ELECTROPHYSIOLOGY; ELECTRORETINOGRAM; HISTOPATHOLOGY; MICROSCOPY; MORBIDITY; MOUSE; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTIC NERVE; OPTIC NERVE ATROPHY; OPTIC NEURITIS; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RETINA GANGLION CELL; SPINAL CORD FUNCTION; TRANSMISSION ELECTRON MICROSCOPY; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; VISUAL SYSTEM FUNCTION;

AXONAL DEGENERATION; NEURODEGENERATION; NEUROFILAMENTS; NEUROOPHTHALMOLOGY; OPTIC NEURITIS;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURODEGENERATIVE DISEASES; NEUROFILAMENT PROTEINS; OPTIC NERVE; OPTIC NEURITIS; RETINAL GANGLION CELLS;

EID: 84879566367     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-11899     Document Type: Article

References (36)

1. Bjartmar C, Wujek JR, Trapp BD. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci. 2003;206:165-171.
2. Bjartmar C, Kinkel RP, Kidd G, et al. Axonal loss in normalappearing white matter in a patient with acute MS. Neurology. 2001;57:1248-1252.
3. DeLuca GC, Williams K, Evangelou N, et al. The contribution of demyelination to axonal loss in multiple sclerosis. Brain. 2006;129:1507-1516.
4. Petzold A. Neurofilament phosphoforms: surrogate markers for axonal injury, degeneration and loss. J Neurol Sci. 2005; 233:183-198.
5. Petzold A, Plant GT. The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies. Mult Scler Int. 2012;2012:217802.
6. Petzold A, Rejdak K, Plant GT. Axonal degeneration and inflammation in acute optic neuritis. J Neurol Neurosurg Psychiatry. 2004;75:1178-1180.
7. Brettschneider J, Petzold A, Junker A, et al. Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis. Mult Scler. 2006;12:143-148.
8. Pasol J, Feuer W, Yang C, et al. Phosphorylated neurofilament heavy chain correlations to visual function, optical coherence tomography, and treatment. Mult Scler Int. 2010;2010:542691.
9. Optic Neuritis Study Group. Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial. Ophthalmology. 2007;115:1079-1082.
10. Petzold A, Eikelenboom MJ, Keir G, et al. Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study. J Neurol Neurosurg Psychiatry. 2005;76:206-211.
11. Petzold A, Brassat D, Mas P, et al. Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis. Mult Scler. 2004;10:281-283.
12. Aboul-Enein F, Weiser P, Hoftberger R, et al. Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis. Acta Neuropathol (Berl). 2006;111:539-547.
13. Sakuma H, Kohyama K, Park IK, et al. Clinicopathological study of a myelin oligodendrocyte glycoprotein-induced demyelinating disease in LEW.1AV1 rats. Brain. 2004;127: 2201-2213.
14. Shao H, Huang Z, Sun SL, et al. Myelin/oligodendrocyte glycoprotein-specific T-cells induce severe optic neuritis in the C57BL/6 mouse. Invest Ophthalmol Vis Sci. 2004;45:4060-4065.
15. Raine CS, Traugott U, Nussenblatt RB, et al. Optic neuritis and chronic relapsing experimental allergic encephalomyelitis: relationship to clinical course and comparison with multiple sclerosis. Lab Invest. 1980;42:327-335.
16. Gresle MM, Shaw G, Jarrott B, et al. Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis. J Neurosci Res. 2008;86:3548-3555.
17. Guan Y, Shindler KS, Tabuena P, et al. Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. J Neuroimmunol. 2006; 178:40-48.
18. Bettelli E, Pagany M, Weiner HL, et al. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003;197: 1073-1081.
19. Guy J, Shaw G, Ross-Cisneros FN, et al. Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON). Mol Vis. 2008;14: 2443-2450.
20. Petzold A, Shaw G. Comparison of two ELISA methods for measuring levels of the phosphorylated neurofilament heavy chain. J Immunol Methods. 2006;319:34-40.
21. Lehmensiek V, Sussmuth SD, Brettschneider J, et al. Proteome analysis of cerebrospinal fluid in Guillain-Barre syndrome (GBS). J Neuroimmunol. 2007;185:190-194.
22. Koilkonda RD, Chou TH, Porciatti V, et al. Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus. Arch Ophthalmol. 2010;128:876-883.
23. Yu H, Koilkonda RD, Chou TH, et al. Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model. Proc Natl Acad Sci U S A. 2012;109:E1238-E1247.
24. Porciatti V. The mouse pattern electroretinogram. Doc Ophthalmol. 2007;115:145-153.
25. Ruggeri M, Wehbe H, Jiao S, et al. In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2007;48:1808-1814.
26. Qi X, Lewin AS, Sun L, et al. SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I. Ann Neurol. 2004;56:182-191.
27. Qi X, Sun L, Lewin AS, et al. Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy. Invest Ophthalmol Vis Sci. 2007;48: 5360-5370.
28. Gnanapavan S, Grant D, Pryce G, et al. Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis. Autoimmunity. 2012;45:298-303.
29. Krishnamoorthy G, Saxena A, Mars LT, et al. Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis. Nat Med. 2009;15:626-632.
30. Costello F, Coupland S, Hodge W, et al. Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol. 2006;59:963-969.
31. Trip SA, Schlottmann PG, Jones SJ, et al. Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol. 2005;58:383-391.
32. Enriquez-Algeciras M, Ding D, Chou TH, et al. Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods. Invest Ophthalmol Vis Sci. 2011;52:2405-2411.
33. Hobom M, Storch MK, Weissert R, et al. Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis. Brain Pathol. 2004;14:148-157.
34. Qi X, Lewin AS, Sun L, et al. Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis. J Biol Chem. 2006;281:31950-31962.
35. Suhs KW, Hein K, Sattler MB, et al. A randomized, doubleblind, phase 2 study of erythropoietin in optic neuritis. Ann Neurol. 2012;72:199-210.
36. Qi X, Lewin AS, Sun L, et al. Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis. Invest Ophthalmol Vis Sci. 2007;48: 681-691.