Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells

Cancer Immunology, Immunotherapy

Volumn 62, Issue 7, 2013, Pages 1273-1282

  Galvin, Karen C ^a   Dyck, Lydia ^a   Marshall, Neil A ^a   Stefanska, Anna M ^a   Walsh, Kevin P ^a   Moran, Barry ^a   Higgins, Sarah C ^a   Dungan, Lara S ^a   Mills, Kingston H G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Dendritic cell vaccine; Regulatory T cells; Retinoic acid; TGF ; Tumour immunity

Indexed keywords

DENDRITIC CELL VACCINE; INTERLEUKIN 10; INTERLEUKIN 12; RETINOIC ACID DERIVATIVE; RETINOIC ACID RECEPTOR ALPHA; TOLL LIKE RECEPTOR AGONIST; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INFILTRATION; CANCER SURVIVAL; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MELANOMA B16; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; TREATMENT RESPONSE;

ALDEHYDE DEHYDROGENASE; ANIMALS; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DENDRITIC CELLS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; IMMUNOTHERAPY; INTERLEUKIN-10; INTERLEUKIN-12; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; RECEPTORS, RETINOIC ACID; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84879556121     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1432-8     Document Type: Article

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