Serum bilirubin levels are lower in overweight asymptomatic middle-aged adults: An early indicator of metabolic syndrome?

Metabolism: Clinical and Experimental

Volumn 62, Issue 7, 2013, Pages 976-985

  Jenko Pražnikar, Zala ^a   Petelin, Ana ^a   Jurdana, Mihaela ^a   Žiberna, Lovro ^b  

^a UNIVERSITY OF PRIMORSKA   (Slovenia)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Asymptomatic individuals; Biomarker; Obesity; Pre disease; Primary prevention

Indexed keywords

BILIRUBIN; BILIRUBIN GLUCURONIDE; C REACTIVE PROTEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; ADULT; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD PRESSURE MEASUREMENT; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; DIETARY INTAKE; FAT INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HIP CIRCUMFERENCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NUTRITIONAL STATUS; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL; WAIST HIP RATIO;

ADULT; BILIRUBIN; BIOLOGICAL MARKERS; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; EARLY DIAGNOSIS; FEMALE; HUMANS; INSULIN RESISTANCE; LINEAR MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OVERWEIGHT; REGRESSION ANALYSIS; RISK FACTORS; SLOVENIA;

EID: 84879552117     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.01.011     Document Type: Article

References (38)

1. I. Bondia-Pons, L. Ryan, and J.A. Martinez Oxidative stress and inflammation interactions in human obesity J Physiol Biochem 2012 10.1007/s13105-012-0154-2
2. M. D'Archivio, G. Annuzzi, and R. Varì Predominant role of obesity/insulin resistance in oxidative stress development Eur J Clin Invest 42 2012 70 78
3. B. Frei, R. Stocker, and B.N. Ames Antioxidant defenses and lipid peroxidation in human blood plasma Proc Natl Acad Sci USA 85 1988 9748 9752
4. L. Vitek The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases Front Pharmacol. 3 2012 55
5. L. Vítek, M. Jirsa, and M. Brodanová Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels Atherosclerosis 160 2002 449 456
6. S.H. Choi, K.E. Yun, and H.J. Choi Relationships between serum total bilirubin levels and metabolic syndrome in Korean adults Nutrition, metabolism, and cardiovascular diseases: NMCD 2011 10.1016/j.numecd.2011.03.001
7. H.-J. Hwang, and S.-H. Kim Inverse relationship between fasting direct bilirubin and metabolic syndrome in Korean adults Clin Chim Acta 411 2010 1496 1501
8. J. Jo, J.E. Yun, and H. Lee Total, direct, and indirect serum bilirubin concentrations and metabolic syndrome among the Korean population Endocrine 39 2010 182 189
9. K.-M. Kwon, J.-H. Kam, and M.-Y. Kim Inverse association between total bilirubin and metabolic syndrome in rural Korean women J Womens Health 2011 20 2002 963 969
10. Y. Wu, M. Li, and M. Xu Low serum total bilirubin concentrations are associated with increased prevalence of metabolic syndrome in Chinese J Diabetes 3 2011 217 224
11. L.-Y. Lin, H.-K. Kuo, and J.-J. Hwang Serum bilirubin is inversely associated with insulin resistance and metabolic syndrome among children and adolescents Atherosclerosis 203 2009 563 568
12. D.R. Matthews, J.P. Hosker, and A.S. Rudenski Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
13. K.G. Alberti, R.H. Eckel, and S.M. Grundy Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 2009 1640 1645
14. R. Laukkanen, P. Oja, and M. Pasanen Validity of a two kilometre walking test for estimating maximal aerobic power in overweight adults Int J Obes Relat Metab Disord 16 1992 263 268
15. Canadian Society for Exercise Physiology (CSEP): the Canadian Physical Activity, Fitness and Lifestyle Appraisal (CPAFLA) 3rd ed. Ottawa, Ontario, Canada. 2004.
16. F. Biering-Sørensen Physical measurements as risk indicators for low-back trouble over a one-year period Spine (Phila Pa 1976) 9 1984 106 119
17. W. Wonisch, A. Falk, and I. Sundl Oxidative stress increases continuously with BMI and age with unfavourable profiles in males The aging male: the official journal of the International Society for the Study of the Aging Male 2012 10.3109/13685538.2012.669436
18. S. Sun, Y. Ji, and S. Kersten Mechanisms of inflammatory responses in obese adipose tissue Annu Rev Nutr 32 2012 261 286
19. B.E. Wisse The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity J Am Soc Nephrol 15 2004 2792 2800
20. U.I. Khan, D. Wang, and R.C. Thurston Burden of subclinical cardiovascular disease in "metabolically benign" and "at-risk" overweight and obese women: the Study of Women's Health Across the Nation (SWAN) Atherosclerosis 217 2011 179 186
21. R. Schnabel, and S. Blankenberg Oxidative stress in cardiovascular disease: successful translation from bench to bedside? Circulation 116 2007 1338 1340
22. T. Maruhashi, J. Soga, and N. Fujimura Hyperbilirubinemia, augmentation of endothelial function, and decrease in oxidative stress in Gilbert syndrome Circulation 126 2012 598 603
23. M. Madhavan, W.A. Wattigney, and S.R. Srinivasan Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults Atherosclerosis 131 1997 107 113
24. H.-J. Hwang, S.-W. Lee, and S.-H. Kim Relationship between bilirubin and C-reactive protein Clin Chem Lab Med: CCLM/FESCC 49 2011 1823 1828
25. K. Ohnaka, S. Kono, and T. Inoguchi Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women Diabetes Res Clin Pract 88 2010 103 110
26. S. Yoshino, S. Hamasaki, and S. Ishida Relationship between bilirubin concentration, coronary endothelial function, and inflammatory stress in overweight patients J Atheroscler Thromb 18 2011 403 412
27. K. Yu, C. Kim, and E. Sung Association of serum total bilirubin with serum high sensitivity C-reactive protein in middle-aged men Korean J Fam Med. 32 2011 327 333
28. D. Young, S. Camhi, and T. Wu Relationships among changes in C-reactive protein and cardiovascular disease risk factors with lifestyle interventions Nutr Metab Cardiovasc Dis 2012 10.1016/j.numecd.2012.05.003
29. C.A. Larsson, L. Kroll, and L. Bennet Leisure time and occupational physical activity in relation to obesity and insulin resistance: a population-based study from the Skaraborg Project in Sweden Metabolism 61 2012 590 598
30. M. Atalay, and C.K. Sen Physical exercise and antioxidant defenses in the heart Ann N Y Acad Sci 874 1999 169 177
31. R. Ajja, D.-C. Lee, and X. Sui Usefulness of serum bilirubin and cardiorespiratory fitness as predictors of mortality in men Am J Cardiol 108 2011 1438 1442
32. D.L. Swift, N.M. Johannsen, and C.P. Earnest Effect of different doses of aerobic exercise training on total bilirubin levels Med Sci Sports Exerc 44 2012 569 574
33. J. Guest, A. Bilgin, and R. Pearce Evidence for under-nutrition in adolescent females using routine dieting practices Asia Pac J Clin Nutr 19 2010 526 533
34. C. Andersson, P. Weeke, and E.L. Fosbøl Acute effect of weight loss on levels of total bilirubin in obese, cardiovascular high-risk patients: an analysis from the lead-in period of the Sibutramine Cardiovascular Outcome trial Metabolism: clinical and experimental 58 2009 1109 1115
35. E. Silverman, J. Sapala, and H. Appelman Regression of hepatic steatosis in morbidly obese persons after gastric bypass Am J Clin Pathol 104 1995 23 31
36. P. Giral, V. Ratziu, and P. Couvert Plasma bilirubin and gamma-glutamyltransferase activity are inversely related in dyslipidemic patients with metabolic syndrome: relevance to oxidative stress Atherosclerosis 210 2010 607 613
37. A.C. Bulmer, H.J. Verkade, and K.H. Wagner Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection Prog Lipid Res 2012 10.1016/j.plipres.2012.11.001
38. A.R. Bhuiyan, S.R. Srinivasan, and W. Chen Association of serum bilirubin with pulsatile arterial function in asymptomatic young adults: the Bogalusa Heart Study Metab Clin Exp 57 2008 612 616